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Controlled clinical investigation of trimeprazine as a sleep-inducer in normal subjects.

Abstract：

:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug on Nights 4-6, and then withdrawal effects were recorded on Nights 7-9. The subjective effects of the drug and EEG sleep variables were determined on these nights. The results showed that the drug might have had dose related effects. REM-sleep was increased by 10 mg doses, which also caused an increase in SW sleep. There was no significant change after the 20 mg dose. Significant REM rebound was not observed after withdrawal of either dose. These characteristics may be of value in the treatment of certain aspects of sleep disturbances.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Kayed K,Hansen T,Godtlibsen OB

doi

10.1007/BF00606405

subject

Has Abstract

pub_date

1977-03-11 00:00:00

pages

163-7

issue

3

eissn

0031-6970

issn

1432-1041

journal_volume

11

pub_type

临床试验,杂志文章

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