The binding of ibuprofen to plasma proteins.

abstract：OBJECTIVE:To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinetics of lovastatin. METHODS:In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment wi...

journal_title：European journal of clinical pharmacology

authors： Bucher M,Mair G,Kees F

更新日期：2002-01-01 00:00:00

abstract：:The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled n...

journal_title：European journal of clinical pharmacology

authors： Guerret M,Cheymol G,Hubert M,Julien-Larose C,Lavene D

更新日期：1989-01-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00

abstract：:Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects ...

journal_title：European journal of clinical pharmacology

authors： Ohtsubo K,Fujii N,Higuchi S,Aoyama T,Goto I,Tatsuhara T

更新日期：1992-01-01 00:00:00

abstract：:The antihypertensive effect of labetalol (L) was compared with that of clonidine (C) in a randomized cross-over study in 17 hypertensive outpatients on bendrofluazide (B). After treatment for two weeks with B(5 mg qd), either L (100 mg tid) or C (0.1 mg tid) was given and their doses were titrated at 2-weekly visits u...

journal_title：European journal of clinical pharmacology

authors： Lilja M,Jounela AJ,Karppanen H

更新日期：1982-01-01 00:00:00

abstract：:A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5 alpha-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Depré M,Schwartz JI,Tjandramaga TB,Winchell GA,De Lepeleire I,Ng J,De Schepper PJ

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:This exploratory study was aimed at elucidating the pharmacogenetics of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) and their implications on docetaxel pharmacokinetics and pharmacodynamics in local Chinese nasopharyngeal cancer patients. METHODS:A total of 59 single nucleotide polymorphisms (SNPs)...

journal_title：European journal of clinical pharmacology

authors： Chew SC,Lim J,Singh O,Chen X,Tan EH,Lee EJ,Chowbay B

更新日期：2014-02-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：:For model identification and parameter estimation in the framework of linear pharmacokinetics it is most often assumed that the disposition function is a finite sum of exponential functions with time constants lambda i and associated coefficients Ci. Least-square fitting procedures are used to estimate the coefficient...

journal_title：European journal of clinical pharmacology

authors： Schwilden H,Honerkamp J,Elster C

更新日期：1993-01-01 00:00:00

abstract：:The chronic oral administration of 0.07 mg digitoxin o.d. for up to 58 days to 12 healthy volunteers caused a small drop in mean heart rate HR (95% CI: -7.9 to -1.6 beats.min-1), in mean diastolic blood pressure (95% CI: -8.3 to -0.4 mmHg), shortening of the QTc-interval (95% CI: -42 to -19 ms), shortening of the HR-c...

journal_title：European journal of clinical pharmacology

authors： de Mey C,Elich D,Schroeter V,Butzer R,Belz GG

更新日期：1992-01-01 00:00:00

abstract：:In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in ...

journal_title：European journal of clinical pharmacology

authors： Lemmer B,Scheidel B,Blume H,Becker HJ

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The study aimed to describe the dispensing of benzodiazepines and benzodiazepine-related drugs (z-hypnotics) to pregnant women and to study the characteristics of these women and the extent of co-medication. METHODS:A population-based cohort study was conducted based on the linkage of nationwide registries: th...

journal_title：European journal of clinical pharmacology

authors： Riska BS,Skurtveit S,Furu K,Engeland A,Handal M

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

journal_title：European journal of clinical pharmacology

authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

更新日期：2011-08-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmaco...

journal_title：European journal of clinical pharmacology

authors： Choi DH,Shin WG,Choi JS

更新日期：2008-05-01 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：:The effects of the beta-blocker atenolol on vigilance, concentration, and psychophysiological condition were determined by measuring visual reaction time and choice reaction time in volunteers subjected to combined physical and mental stress. Atenolol 50 mg or placebo were administered for three days in a double-blind...

journal_title：European journal of clinical pharmacology

authors： Harms D

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex Synchro-Breathe (SB) device and an Evohaler pMDI (EH) device using adrenal suppression and ea...

journal_title：European journal of clinical pharmacology

authors： Nair A,McKinlay L,Williamson P,Short P,Burns P,Lipworth BJ

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over t...

journal_title：European journal of clinical pharmacology

authors： Hirai T,Hanada K,Kanno A,Akashi M,Itoh T

更新日期：2019-06-01 00:00:00

abstract：:General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readil...

journal_title：European journal of clinical pharmacology

authors： Vaughan DP,Mallard DJ,Trainor A,Mitchard M

更新日期：1975-02-28 00:00:00

abstract：:The pharmacokinetics of cephacetrile were studied after its administration as a single i.v. bolus injection of 15 mg/kg body weight to 11 patients with terminal renal inpairment undergoing haemodialysis for 6 h. A two-compartment kinetic model was used to describe the biphasic decrease in plasma concentration. The qua...

journal_title：European journal of clinical pharmacology

authors： Dominguez-Gil A,Lanao JM,Tabernero JM,Rodriguez Commes JL,de Castro S

更新日期：1979-08-01 00:00:00

abstract：PURPOSE:To investigate associations between antidepressant use patterns and risk of fatal and non-fatal suicidal behaviours in older adults who initiated antidepressant therapy. METHOD:A national population-based cohort study conducted among Swedish residents aged ≥ 75 years who initiated antidepressant treatment. Pat...

journal_title：European journal of clinical pharmacology

authors： Hedna K,Andersson Sundell K,Hamidi A,Skoog I,Gustavsson S,Waern M

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes. METHODS:In 20 healthy non-pregnant women aged 18-45 years, the serum concent...

journal_title：European journal of clinical pharmacology

authors： Kjærstad MB,Nielsen F,Nøhr-Jensen L,Zwisler S,Brøsen K,Andersen HR

更新日期：2010-12-01 00:00:00

abstract：:A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC...

journal_title：European journal of clinical pharmacology

authors： Benkö S,Grézal G,Nagy E,Klebovich I

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Older people with advanced frailty are among the highest consumers of medications. When life expectancy is limited, some of these medications are likely to be inappropriate. The aim of this study was to compare STOPPFrail, a concise, easy-to-use, deprescribing tool based on explicit criteria, with gold standard...

journal_title：European journal of clinical pharmacology

authors： Curtin D,Dukelow T,James K,O'Donnell D,O'Mahony D,Gallagher P

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual variation in the metabolic ratio (MR), i.e. quinine/3-hydroxyquinine. METHODS:Data from a previous study (A) was used for determination of the MR of quini...

journal_title：European journal of clinical pharmacology

authors： Mirghani RA,Ericsson O,Tybring G,Gustafsson LL,Bertilsson L

更新日期：2003-05-01 00:00:00

abstract：AIMS:Thiazolidinediones administration is assumed to be related with an improvement of endothelial dysfunction (ED); nevertheless, previous studies have been inconsistent. For this reason, the present meta-analysis was directed to estimate if thiazolidinediones were related to endothelial dysfunction improvement by usi...

journal_title：European journal of clinical pharmacology

authors： Stojanović M,Prostran M,Radenković M

更新日期：2016-04-01 00:00:00

abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

journal_title：European journal of clinical pharmacology

authors： McBurney A,Henry JA,Ward JW

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Tamoxifen is one of the cornerstones of endocrine therapy for breast cancer. Recently, the decreased activity CYP3A4*22 allele and the loss of function CYP3A5*3 allele have been described as potential factors that could help to explain the inter-patient variability in tamoxifen metabolism. The aim of this st...

journal_title：European journal of clinical pharmacology

authors： Sanchez Spitman AB,Moes DJAR,Gelderblom H,Dezentje VO,Swen JJ,Guchelaar HJ

更新日期：2017-12-01 00:00:00

abstract：:The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 m...

journal_title：European journal of clinical pharmacology

authors： Mondorf AW,Breier J,Hendus J,Scherberich JE,Mackenrodt G,Shah PM,Stille W,Schoeppe W

更新日期：1978-05-17 00:00:00