Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil.


AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmacokinetic parameters of verapamil and one of its metabolites, norverapamil, were compared after oral administration of verapamil (60 mg) in the presence or absence of oral atorvastatin (40 mg) in 12 healthy volunteers. RESULTS:Pharmacokinetics of verapamil were significantly altered by the coadministration of atorvastatin compared with those of without atorvastatin. For example, the total area under the plasma-concentration time curve to the last measured time, 24 h, in plasma (AUC(0-24) (h)) of verapamil increased significantly by 42.8%. Thus, the relative bioavailability increased by the same magnitude with atorvastatin. Although the AUC(0-24) (h) of norverapamil was not significantly different between two groups of humans, the AUC(0-24) (h, norverapamil)/ AUC(0-24) (h, verapamil) ratio was significantly reduced (27.5% decrease) with atorvastatin. CONCLUSION:The above data suggest that atorvastatin could inhibit the absorption of verapamil via inhibition of P-gp and/or the metabolism of verapamil by CYP3A4 in humans.


Eur J Clin Pharmacol


Choi DH,Shin WG,Choi JS




Has Abstract


2008-05-01 00:00:00












  • Plasma levels and pharmacokinetics of cyclofenil after oral administration to man.

    abstract::Cyclofenil was given as a single oral dose of 200 mg, and also as 200 mg/day for eight days, to seven healthy female volunteers. Plasma was analyzed for the active metabolite and pharmacokinetic modelling was performed. A biological half life of 29 h was bound after the single dose and 18 h after the eighth day of con...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Borgström L

    更新日期:1981-02-01 00:00:00

  • Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications.

    abstract:PURPOSE:Drug utilization studies have applied different methods to various data types to describe medication use, which hampers comparisons across populations. The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a unif...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究


    authors: Abbing-Karahagopian V,Huerta C,Souverein PC,de Abajo F,Leufkens HG,Slattery J,Alvarez Y,Miret M,Gil M,Oliva B,Hesse U,Requena G,de Vries F,Rottenkolber M,Schmiedl S,Reynolds R,Schlienger RG,de Groot MC,Klungel OH,va

    更新日期:2014-07-01 00:00:00

  • Pharmacokinetic studies of oral L-threo-3,4-dihydroxyphenylserine in normal subjects and patients with familial amyloid polyneuropathy.

    abstract::The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Suzuki T,Higa S,Sakoda S,Ueji M,Hayashi A,Takaba Y,Nakajima A

    更新日期:1982-01-01 00:00:00

  • A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials.

    abstract::Migraine is the most common cause of vascular headache and a highly prevalent illness. In the last 20 years, the discovery of new agents has increased clinical research on migraine. In most of clinical trials that have been conducted, the efficacy was established using a placebo as a control treatment. The objective o...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,meta分析


    authors: Macedo A,Farré M,Baños JE

    更新日期:2006-03-01 00:00:00

  • Pharmacoepidemiology of psychotropic drugs in patients with severe mental disorders in Italy. Italian Collaborative Study Group on the Outcome of Severe Mental Disorders.

    abstract:OBJECTIVE:To describe the epidemiology of psychotropic drug use in a sample of Italian outpatient psychiatric services. METHODS:Drug-utilisation survey conducted within the framework of a broader prospective follow-up study with 67 Italian outpatient psychiatric services. RESULTS:The data concern 2322 patients recrui...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究


    authors: Tognoni G

    更新日期:1999-11-01 00:00:00

  • Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis.

    abstract:PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

    更新日期:2010-11-01 00:00:00

  • Influence of triazolam on thermal heat balance in poor sleepers.

    abstract::The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Libert JP,Weber LD,Amoros C,Muzet A,Ehrhart J,Follenius M

    更新日期:1984-01-01 00:00:00

  • Pharmacokinetics of metipranolol in normal man.

    abstract::The pharmacokinetic parameters of deacetyl metipranolol were determined after i.v. infusion of increasing doses (6-25mg) in 17 normal volunteers. In a second cross-over trial, deacetyl metipranolol 10 and 20mg were infused in a further 10 subjects, and in a third trial another 20 volunteers received metipranolol 40mg ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Abshagen U,Betzien G,Kaufmann B,Endele G

    更新日期:1982-01-01 00:00:00

  • Fluocortolone: pharmacokinetics and effect on ACTH and cortisol secretion during daily and alternate-day administration.

    abstract::The pharmacokinetics of fluocortolone and its effect on the circadian rhythm of plasma cortisol and ACTH have been studied during different schedules of oral administration. Groups of 6 healthy male adults were given a single daily dose of fluocortolone 5, 10 and 20 mg, and another group received 20 mg every second da...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tüber U,Posern U,Bickel U,Matthes H,Voigt K

    更新日期:1988-01-01 00:00:00

  • Long acting beta-blockers in the twenty fourth hour.

    abstract::Fifteen mild to moderate hypertensives were submitted to exercise testing using a bicycle ergometer with a fixed load. Heart rate, blood pressure and ECG were recorded throughout 5 min exercise and 10 min recovery. Oxygen uptake was measured during the final minute of exercise and blood glucose estimation and serum dr...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Hackett GI,Harrison P,Kershaw S

    更新日期:1983-01-01 00:00:00

  • Pharmacokinetics and safety of escalating single and repeat oral doses of GW420867X, a novel non-nucleoside reverse transcriptase inhibitor.

    abstract:OBJECTIVE:To assess the pharmacokinetics, safety and tolerability of escalating oral doses of GW420867X, a non-nucleoside reverse transcriptase inhibitor, was investigated in healthy male volunteers in a randomized, double-blind placebo-controlled study. METHODS:Study subjects were divided into four groups of 12 subje...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Moore KH,Cass LM,Dallow N,Hardman TC,Jones A,Boyce M,Prince WT

    更新日期:2001-01-01 00:00:00

  • Overdosage of antidepressants: clinical and pharmacokinetic aspects.

    abstract::Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

    更新日期:1982-01-01 00:00:00

  • Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method.

    abstract:PURPOSE:The 388A>G and the 521T>C polymorphism of the SLCO1B1 gene affect the activity of the uptake transporter OATP1B1, thus influencing kinetics, safety, and efficacy of substrate drugs. To evaluate the impact of these polymorphisms in populations of different ethnic origins, it is important to know their frequencie...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Aklillu E,Mugusi S,Ngaimisi E,Hoffmann MM,König S,Ziesenitz V,Mikus G,Haefeli WE,Weiss J

    更新日期:2011-11-01 00:00:00

  • Influence and interference of isosorbide dinitrate and food intake on superior mesenteric artery impedance in humans.

    abstract::The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

    更新日期:1995-01-01 00:00:00

  • Comparison of labetalol and clonidine in hypertension.

    abstract::The antihypertensive effect of labetalol (L) was compared with that of clonidine (C) in a randomized cross-over study in 17 hypertensive outpatients on bendrofluazide (B). After treatment for two weeks with B(5 mg qd), either L (100 mg tid) or C (0.1 mg tid) was given and their doses were titrated at 2-weekly visits u...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lilja M,Jounela AJ,Karppanen H

    更新日期:1982-01-01 00:00:00

  • The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects.

    abstract:BACKGROUND:Zolmitriptan is a 5HT(1B/1D) receptor agonist effective in the acute treatment of migraine. Clinical trials in the USA and Europe have demonstrated the optimal oral therapeutic dose to be 2.5 mg. The 2.5-mg oral tablet has recently been licensed in Japan. OBJECTIVE:To compare the pharmacokinetics of zolmitr...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Yates RA,Tateno M,Nairn K,Ikegami A,Dane A,Kemp J

    更新日期:2002-07-01 00:00:00

  • The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers.

    abstract:PURPOSE:Concomitant treatment with the glucose-lowering drug metformin and the platelet aggregation inhibitor dipyridamole often occurs in patients with type 2 diabetes mellitus who have suffered a cerebrovascular event. The gastrointestinal uptake of metformin is mediated by the human equilibrative nucleoside transpor...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: El Messaoudi S,Russel FG,Colbers A,Bandell CC,van den Broek PH,Burger DM,Rongen GA,Riksen NP

    更新日期:2016-06-01 00:00:00

  • Long-term effects of glipizide on insulin secretion and blood glucose control in patients with non-insulin-dependent diabetes mellitus.

    abstract::Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

    更新日期:1992-01-01 00:00:00

  • Systolic time intervals in evaluation of the negative inotropic effect after single oral doses of mexiletine and disopyramide.

    abstract::A placebo-controlled, single blind, crossover study was done to evaluate the inotropic effects of single oral doses of mexiletine and disopyramide assessed by the measurement of Systolic Time Intervals (STI). Each of 8 healthy volunteers received five treatments in random order: 200 and 400 mg mexiletine, 100 and 200 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rousson D,Piolat C,Galleyrand J,Ferry S,Boissel JP

    更新日期:1986-01-01 00:00:00

  • Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects.

    abstract:OBJECTIVE:To evaluate the effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects. METHODS:A single 5-mg capsule of tropisetron was administered orally to 13 healthy subjects. Plasma concentrations were determined by validated HPLC procedures and data were analyzed by using nonc...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Kim MK,Cho JY,Lim HS,Hong KS,Chung JY,Bae KS,Oh DS,Shin SG,Lee SH,Lee DH,Min B,Jang IJ

    更新日期:2003-06-01 00:00:00

  • Genetic and environmental risk factors for oral anticoagulant overdose.

    abstract:BACKGROUND:Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. OBJECTIVES:To determine the relative frequencies of different risk factors for OA overdose including di...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Verstuyft C,Robert A,Morin S,Loriot MA,Flahault A,Beaune P,Funck-Brentano C,Jaillon P,Becquemont L

    更新日期:2003-03-01 00:00:00

  • Cardiovascular and respiratory effects of the beta-adrenoceptive antagonist sotalol: studies in health, angina pectoris and obstructive lung disease.

    abstract::The cardiovascular and respiratory actions of the adrenergic beta adrenoceptive drug sotalol have been studied in an open, short term trial. Fifteen patients with angina performed standardized orthostatic and exercise tests before and after injection of 20 mg sotalol intravenously. Although there was a significant red...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Areskog NH,Cullhed I,Ringqvist I,Ström G

    更新日期:1975-08-14 00:00:00

  • Clinical trial of brinase and anticoagulants as a method of treatment for advanced limb ischemia.

    abstract::A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

    更新日期:1979-09-01 00:00:00

  • Drug-associated non-pyrogenic hyperthermia: a narrative review.

    abstract:PURPOSE:Hyperthermia occurs when heat accumulation surpasses the body's ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. METHODS:A comprehensive search was...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bongers KS,Salahudeen MS,Peterson GM

    更新日期:2020-01-01 00:00:00

  • Variation in the binding affinity of warfarin and phenprocoumon to human serum albumin in relation to surgery.

    abstract::The binding equilibria of warfarin and phenprocoumon with defatted human serum albumin were studied by equilibrium dialysis in 33 mM sodium phosphate buffer, pH 7.4, 37 degrees C. The binding isotherms for both ligands were consistent with binding to two similar and independent sites in the albumin molecule. The bindi...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Vorum H,Jørgensen HR,Brodersen R

    更新日期:1993-01-01 00:00:00

  • Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.

    abstract::It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three ti...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Lökken P,Olsen I,Bruaset I,Norman-Pedersen K

    更新日期:1975-04-04 00:00:00

  • Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man.

    abstract:OBJECTIVE:The pharmacokinetics of orally and intravenously administered valsartan were determined in two studies. In a first pilot study, three i.v. doses of valsartan were given in an ascending manner (5, 10 and 20 mg) to evaluate tolerability and basic pharmacokinetics of the i.v. formulation. In a second study, the ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flesch G,Müller P,Lloyd P

    更新日期:1997-01-01 00:00:00

  • Utilization of chi-square statistics for screening adverse drug-drug interactions in spontaneous reporting systems.

    abstract:PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Gosho M,Maruo K,Tada K,Hirakawa A

    更新日期:2017-06-01 00:00:00

  • Polypharmacy and medication regimen complexity as factors associated with staff informant rated quality of life in residents of aged care facilities: a cross-sectional study.

    abstract:PURPOSE:The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). METHODS:A cross-sectional study of 383 residents from six Australian RACFs was conducted. The pr...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lalic S,Jamsen KM,Wimmer BC,Tan EC,Hilmer SN,Robson L,Emery T,Bell JS

    更新日期:2016-09-01 00:00:00

  • A collaborative intervention to improve surgical antibiotic prophylaxis in children: results from a prospective multicenter study.

    abstract:PURPOSE:The use of surgical antibiotic prophylaxis (SAP) in children is poorly characterized. Our aim was to evaluate the effectiveness of a quality improvement (QI) intervention targeting SAP in children, by means of a multicenter prospective intervention study, with a before and after design. METHODS:We prospectivel...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Ciofi Degli Atti M,Alegiani SS,Raschetti R,Arace P,Giusti A,Spiazzi R,Raponi M,APACHE Study Group.

    更新日期:2017-09-01 00:00:00