当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil.

Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil.

Abstract：

AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmacokinetic parameters of verapamil and one of its metabolites, norverapamil, were compared after oral administration of verapamil (60 mg) in the presence or absence of oral atorvastatin (40 mg) in 12 healthy volunteers. RESULTS:Pharmacokinetics of verapamil were significantly altered by the coadministration of atorvastatin compared with those of without atorvastatin. For example, the total area under the plasma-concentration time curve to the last measured time, 24 h, in plasma (AUC(0-24) (h)) of verapamil increased significantly by 42.8%. Thus, the relative bioavailability increased by the same magnitude with atorvastatin. Although the AUC(0-24) (h) of norverapamil was not significantly different between two groups of humans, the AUC(0-24) (h, norverapamil)/ AUC(0-24) (h, verapamil) ratio was significantly reduced (27.5% decrease) with atorvastatin. CONCLUSION:The above data suggest that atorvastatin could inhibit the absorption of verapamil via inhibition of P-gp and/or the metabolism of verapamil by CYP3A4 in humans.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Choi DH,Shin WG,Choi JS

doi

10.1007/s00228-007-0447-5

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

445-9

issue

5

eissn

0031-6970

issn

1432-1041

journal_volume

64

pub_type

临床试验,杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians.

    abstract：OBJECTIVE:The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg). PATIENTS:The ages of the patients ranged from...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050158

    authors： Ajayi AA,Afolabi MA,Balogun MO,Adigun AQ,Ajayi OE,Akintomide AO

    更新日期：1996-01-01 00:00:00

  • The effects and side effects of laquinimod for the treatment of multiple sclerosis patients: a systematic review and meta-analysis of clinical trials.

    abstract：PURPOSE:Although studies have shown the efficacy of laquinimod (LAQ) on disease progression in patients with multiple sclerosis (MS), there is some controversy about whether it improves the types of outcomes and side effects. The main purpose of the present study was to systematically review and meta-analyze the effica...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-019-02827-6

    authors： Rouhi F,Mohammadpour Z,Noureini SK,Abbastabar H,Harirchian MH,Bitarafan S

    更新日期：2020-05-01 00:00:00

  • Factors influencing drug protein binding in patients with end stage renal failure.

    abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01428386

    authors： Vanholder R,De Smet R,Ringoir S

    更新日期：1993-01-01 00:00:00

  • The effect of nitric oxide-donating vasodilators on monocyte chemotaxis and intracellular cGMP concentrations in vitro.

    abstract：:The effects of sodium nitroprusside (SNP) and 3-morpholino sydnonimine (SIN-1), isosorbide dinitrate (ISDN) and glyceryl trinitrate (GTN), and molsidomine (the inactive precursur of SIN-1) on monocyte chemotaxis and cyclic GMP (cGMP) concentration were studied. SNP and SIN-1 inhibited monocyte N-formyl-methionyl-leucy...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315350

    authors： Bath PM

    更新日期：1993-01-01 00:00:00

  • Trends in paediatric macrolide use in five European countries-a population-based study.

    abstract：PURPOSE:The study aims to analyse overall as well as subgroup-specific outpatient paediatric macrolide use in five European countries, including time trends of macrolide prescription rates, and to provide potential targets for future interventions aiming to promote judicious macrolide use. METHODS:Macrolide prescripti...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1870-7

    authors： Holstiege J,Enders D,Schink T,Innocenti F,Oteri A,Bezemer I,Kaguelidou F,Molokhia M,Poluzzi E,Puccini A,Ulrichsen SP,Sturkenboom MC,Trifirò G,Garbe E

    更新日期：2015-08-01 00:00:00

  • Unwanted symptoms in depressed patients treated with viloxazine: an algorithm for identification of illness-related symptoms.

    abstract：:Ninety-six depressed outpatients from 5 centres were given viloxazine 200-400 mg/day. The treatment produced significant clinical improvement as evaluated by the Hamilton Rating Scale for Depression. Thirteen patients dropped-out because of possible side effects. Many untoward symptoms were described by all the patien...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00613832

    authors： Maistrello I,Grassi G,Bertolino A,Valerio P,Pistollato G,Soverini S

    更新日期：1983-01-01 00:00:00

  • Disopyramide concentrations in human plasma and saliva: comparison of disopyramide concentrations in saliva and plasma unbound concentrations.

    abstract：OBJECTIVE:This study was performed to investigate whether it is possible to use saliva instead of blood usually used for therapeutic drug monitoring (TDM) of disopyramide. METHODS:Six healthy male volunteers ingested 200 mg of disopyramide base, and the disopyramide concentrations in saliva and plasma (total and unbou...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280050250

    authors： Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

    更新日期：1997-01-01 00:00:00

  • Dose-titration study of alfuzosin, a new alpha 1-adrenoceptor blocker, in essential hypertension.

    abstract：:An open, dose-titration study of alfuzosin, a new selective post-synaptic alpha 1-adrenoceptor antagonist with additional direct vasodilator properties has been performed. After a 3-week run-in placebo period, 12 patients with essential hypertension received alfuzosin 5 mg oral b.d., and then the dose was doubled ever...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00555503

    authors： Leto di Priolo S,Priore P,Cocco G,Sfrisi C,Cazor JL

    更新日期：1988-01-01 00:00:00

  • Use of fixed doses of beta blocking drugs in the treatment of hypertension. Randomised study of atenolol and penbutolol.

    abstract：:Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00637507

    authors： Lameijer LD,Voermans LA,Houtzagers JJ,Chadha DR

    更新日期：1981-01-01 00:00:00

  • Drug safety in pregnancy: the German Embryotox institute.

    abstract：:Since 1988, the German Embryotox institute combines individual counselling of pregnant women and their health care providers (HCP) with research on drug safety in pregnancy. In addition, Embryotox offers web-based information which covers the most important and most frequently requested pharmaceutical substances. In c...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-017-2351-y

    authors： Dathe K,Schaefer C

    更新日期：2018-02-01 00:00:00

  • Comparative effects of rifabutin and rifampicin on hepatic microsomal enzyme activity in normal subjects.

    abstract：:The comparative enzyme inducing effects of rifabutin and the chemically related drug rifampicin have been investigated in 8 normal subjects. Rifampicin 600 mg daily for 7 days caused considerable shortening of the antipyrine half-life and a marked increase in antipyrine clearance, associated with an increased rate of ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00615223

    authors： Perucca E,Grimaldi R,Frigo GM,Sardi A,Mönig H,Ohnhaus EE

    更新日期：1988-01-01 00:00:00

  • Genetic polymorphism of CYP2C19 and lansoprazole pharmacokinetics in Japanese subjects.

    abstract：OBJECTIVE:We investigated whether interindividual differences in the pharmacokinetic disposition of lansoprazole are attributed to the genetic polymorphism of CYP2C19 which occurred by two mutations. CYP2C19m1 and CYP2C19m2, in 20 Japanese subjects. METHODS:Polymerase chain reaction (PCR) restriction fragment length p...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050307

    authors： Katsuki H,Nakamura C,Arimori K,Fujiyama S,Nakano M

    更新日期：1997-01-01 00:00:00

  • Correction to: Pharmacoepidemiology resources in Ireland-an introduction to pharmacy claims data.

    abstract：:In the 3rd paragraph and 2nd line of the Conclusion section the correct sentence should be: It is now important to encourage policy and decision makers to facilitate and accommodate future linkage of data. ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s00228-017-2358-4

    authors： Sinnott SJ,Bennett K,Cahir C

    更新日期：2017-11-01 00:00:00

  • The comparative cardiovascular effects of digoxin and food alone and in combination in normal males.

    abstract：:The effects of the ingestion of food and digoxin on the cardiovascular system alone and in combination have been observed in eight healthy subjects. A positive inotropic response was seen following food (2.5 MJ) and intravenous digoxin (0.01 mg/kg) with significant decreases in QS2Index (QS2I) pre-ejection period (PEP...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00615959

    authors： Burgess CD,Crane J

    更新日期：1986-01-01 00:00:00

  • Utilizing physiologically based pharmacokinetic modeling to predict theoretically conceivable extreme elevation of serum flecainide concentration in an anuric hemodialysis patient with cirrhosis.

    abstract：PURPOSE:Higher drug concentrations in complex clinical scenarios in which multiple factors such as drug-drug interactions (DDIs) and comorbidities are simultaneously present are not necessarily rationalized in prospective clinical studies. Physiologically based pharmacokinetic (PBPK) modeling and simulation of the anti...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02861-9

    authors： Doki K,Kuga K,Aonuma K,Ieda M,Homma M

    更新日期：2020-06-01 00:00:00

  • A clinical and pharmacokinetic evaluation of tolmesoxide in hypertensive patients.

    abstract：:The pharmacokinetics, hypotensive effect and tolerability of a new vasodilator, tolmesoxide (T), have been studied in 6 uncontrolled hypertensive patients receiving atenolol and diuretic. After a 50 mg oral dose mean (+/- SD) peak plasma concentration of T was 1.13 +/- 0.29 micrograms/ml-1 and occurred 0.79 +/- 0.40 h...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00568397

    authors： Silas JH,Phillips FC,Freestone S,Tucker GT,Ramsay LE

    更新日期：1981-01-01 00:00:00

  • Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine.

    abstract：:The peripheral histamine-inhibiting and central sedative effects of single oral doses (SOD) and of repeated administration for one week (steady state, SS), of 20 mg hydroxyzine HCL and 10 mg cetirizine have been assessed in 12 healthy volunteers, in a double-blind placebo-controlled cross-over study. Peripheral H1-rec...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00626365

    authors： Levander S,Ståhle-Bäckdahl M,Hägermark O

    更新日期：1991-01-01 00:00:00

  • Bevacizumab increases the risk of gastrointestinal perforation in cancer patients: a meta-analysis with a focus on different subgroups.

    abstract：BACKGROUND:The aim of this meta-analysis was to gather current data and evaluate not only the risk of gastrointestinal (GI) perforation with bevacizumab, but also the potential risk factors for this adverse event. MATERIALS AND METHODS:We carried out a literature search in PubMed for randomized controlled trials (RCTs...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-014-1687-9

    authors： Qi WX,Shen Z,Tang LN,Yao Y

    更新日期：2014-08-01 00:00:00

  • Antidepressants and suicidal behaviour in late life: a prospective population-based study of use patterns in new users aged 75 and above.

    abstract：PURPOSE:To investigate associations between antidepressant use patterns and risk of fatal and non-fatal suicidal behaviours in older adults who initiated antidepressant therapy. METHOD:A national population-based cohort study conducted among Swedish residents aged ≥ 75 years who initiated antidepressant treatment. Pat...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-017-2360-x

    authors： Hedna K,Andersson Sundell K,Hamidi A,Skoog I,Gustavsson S,Waern M

    更新日期：2018-02-01 00:00:00

  • Procaine hydrolysis defect in uraemia does not appear to be due to carbamylation of plasma esterases.

    abstract：:Procaine esterase activity in plasma from patients with renal failure is decreased by 40%. Since cyanate is formed from urea and readily carbamylates certain blood proteins, a possible role for cyanate in the depression of plasma esterase activity in uraemic patients was considered. However, in vitro carbamylation of ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00609899

    authors： Calvo R,Carlos R,Erill S

    更新日期：1983-01-01 00:00:00

  • Beta-blockade antagonism of tyramine-induced rise in blood pressure.

    abstract：:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00540953

    authors： Colombo F,Sega R,Mailland F,Rigo R,Palvarini L,Libretti A

    更新日期：1988-01-01 00:00:00

  • The continuing challenge of providing drug information services to diminish the knowledge--practice gap in medical practice.

    abstract：:Information must be collected, evaluated and utilized to support every qualified activity. Medicine, with a written scientific tradition stretching back more than 2,000 years, is no exception. Here, we discuss a number of important items associated with the establishment of a drug information centre run by clinical ph...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-013-1484-x

    authors： Alván G,Andersson ML,Asplund AB,Böttiger Y,Elwin CE,Gustafsson LL,Öhman B,Törnqvist E

    更新日期：2013-05-01 00:00:00

  • Intensive monitoring of adverse drug reactions in infants and preschool children.

    abstract：:Intensive monitoring of adverse drug reactions (ADR) in infants and preschool children in the paediatric outpatient unit covering the town of Karlovac (150,000 inhabitants) was performed over a period of three months. Data were obtained by physical examination of children and the history given by their parents. In all...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00561025

    authors： Cirko-Begović A,Vrhovac B,Bakran I

    更新日期：1989-01-01 00:00:00

  • Adverse drug reactions related to drugs used in orthostatic hypotension: a prospective and systematic pharmacovigilance study in France.

    abstract：OBJECTIVE:The aim of the present study was to investigate and characterise adverse drug reactions (ADRs) to drugs used in France for orthostatic hypotension (OH). METHODS:In this prospective and systematic study, 121 consecutive out-patients suffering from primary (Parkinson's disease, pure autonomic failure, multiple...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-005-0941-6

    authors： Pathak A,Raoul V,Montastruc JL,Senard JM

    更新日期：2005-07-01 00:00:00

  • What have the ACE-inhibitor trials in postmyocardial patients with left ventricular dysfunction taught us?

    abstract：:A series of elegant experimental studies and careful clinical observation over a decade or more have led to the concept of 'infarct expansion' and 'remodelling' of the heart, culminating in a number of major mortality studies indicating the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in patients af...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Reynolds G,Hall AS,Ball SG

    更新日期：1996-01-01 00:00:00

  • Compliance and medication knowledge among elderly Japanese home-care recipients.

    abstract：OBJECTIVES:To investigate the risk factors for noncompliance in elderly home-care recipients; and to evaluate to what extent regular home visits and drug counseling by a pharmacist contribute to compliance. SUBJECTS:One hundred and sixty-three elderly home-care recipients aged 62 years and over took part in this study...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050609

    authors： Okuno J,Yanagi H,Tomura S,Oka M,Hara S,Hirano C,Tsuchiya S

    更新日期：1999-04-01 00:00:00

  • Effect of imipramine treatment on changes in heart rate and blood pressure during postural and isometric handgrip tests.

    abstract：:Postural and isometric handgrip tests were performed on nine patients with panic disorder and 13 patients with major depression before and after treatment with imipramine for a mean duration of 10 weeks. There were significant increases in resting supine heart rate (HR), systolic, diastolic and mean blood pressures (S...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00265972

    authors： Yeragani VK,Meiri P,Balon R,Pohl R,Golec S

    更新日期：1990-01-01 00:00:00

  • Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man.

    abstract：:The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.9...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00607910

    authors： Padrini R,Barbieri E,Piovan D,Toffoli M,Motta A,Trevi GP,Ferrari M

    更新日期：1985-01-01 00:00:00

  • A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.

    abstract：PURPOSE:The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration (Ctrough) within the target range (50-100 mg/L). METHODS:Ninety-eight childre...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-018-2444-2

    authors： Rodrigues C,Chhun S,Chiron C,Dulac O,Rey E,Pons G,Jullien V

    更新日期：2018-06-01 00:00:00

  • A randomised cross-over study on the haemodynamic effects of oral dofetilide compared with oral sotalol in patients with ischaemic heart disease and sustained ventricular tachycardia.

    abstract：OBJECTIVE:To assess the haemodynamic effects of short-term treatment with dofetilide in comparison with sotalol in patients with ischaemic heart disease. METHODS:Twelve patients with ischaemic heart disease and sustained ventricular tachycardia were treated with dofetilide [500 microg twice daily (b.i.d.)] or sotalol ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00228-002-0464-3

    authors： Boriani G,Biffi M,Bacchi L,Martignani C,Zannoli R,Butrous GS,Branzi A

    更新日期：2002-06-01 00:00:00