当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Comparative lung bioavailability of fluticasone/salmeterol via a breath-actuated spacer and conventional plastic spacers.

Comparative lung bioavailability of fluticasone/salmeterol via a breath-actuated spacer and conventional plastic spacers.

Abstract：

PURPOSE:This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex Synchro-Breathe (SB) device and an Evohaler pMDI (EH) device using adrenal suppression and early fall in serum potassium (K) as surrogates for respirable dose. METHODS:Seventeen healthy volunteers completed this randomised double-blind, double-dummy crossover study. Single doses of placebo/Seretide 250 (total dose ex valve fluticasone 2000 mcg/salmeterol 200 mcg) were administered via the devices. Overnight urinary cortisol/creatinine (OUCC) and serum K were measured at baseline and after each dose. RESULTS:Significant suppression of OUCC and K occurred from baseline with the SB, AP and VM but not with the EH devices. The geometric mean fold suppression (95% confidence interval, p) was: EH, 1.59 (0.80-3.14, p=0.40); AP, 4.26 (3.01-6.02, p<0.001); VM, 3.11 (1.99-4.78, p<0. 001); SB, 3.29 (2.04-5.24, p<0.001). For K, the arithmetic mean fall (mmol/l) (95% confidence interval; p) was: EH, -0.10 (-0.25-0.05, p=0.18); AP, -0.23 (-0.41 to -0.04, p=0.02); VM, -0.22 (-0.44 to -0.01, p=0.04); SB, -0.28 (-0.42 to -0.13, p=0.001). CONCLUSIONS:The breath-actuated SB device was comparable to 'out of the box' small and large volume spacers and produced similar improvements in relative systemic lung bioavailability for fluticasone and salmeterol.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Nair A,McKinlay L,Williamson P,Short P,Burns P,Lipworth BJ

doi

10.1007/s00228-010-0989-9

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

355-363

issue

4

eissn

0031-6970

issn

1432-1041

pii

10.1007/s00228-010-0989-9

journal_volume

67

pub_type

杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Erythropoetin as a novel agent with pleiotropic effects against acute lung injury.

    abstract：:Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00228-010-0938-7

    authors： Kakavas S,Demestiha T,Vasileiou P,Xanthos T

    更新日期：2011-01-01 00:00:00

  • Single and repeated dose kinetics of the hypnotic agent loprazolam in healthy volunteers.

    abstract：:The pharmacokinetics of loprazolam have been studied in eight healthy male volunteers after single and repeated 2 mg oral doses taken at night, for eight nights. The absorption and disposition of unchanged drug (HPLC-GC assay) and receptor active benzodiazepine-type materials (radioreceptor assay) were examined after ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00542354

    authors： Stevens LA,Bevan CD,Salmon J,Krieger J,Perianu M,LeGo A

    更新日期：1983-01-01 00:00:00

  • Torasemide, a new potent diuretic. Double-blind comparison with furosemide.

    abstract：:The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins. Given orally for 5 days, torasemide was clinically very effective and well tolerated. On a weight basis, the diure...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00541464

    authors： Broekhuysen J,Deger F,Douchamps J,Ducarne H,Herchuelz A

    更新日期：1986-01-01 00:00:00

  • No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.

    abstract：PURPOSE:Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00228-017-2392-2

    authors： Vizeli P,Meyer Zu Schwabedissen HE,Liechti ME

    更新日期：2018-03-01 00:00:00

  • Pharmacokinetics of naproxen in elderly patients.

    abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00613525

    authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

    更新日期：1986-01-01 00:00:00

  • Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.

    abstract：OBJECTIVE:UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7 (chromosome 4) nonsynonymous single nucleotide polymorphisms (SNPs) in West African (...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0206-z

    authors： Mehlotra RK,Bockarie MJ,Zimmerman PA

    更新日期：2007-01-01 00:00:00

  • Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England.

    abstract：OBJECTIVE:To investigate whether an association between the use of selective serotonin reuptake inhibitor (SSRI) antidepressants and abnormal bleeding is demonstrated in a large population study. METHODS:An observational cohort study using cohorts from the Drug Safety Research Unit's prescription event monitoring data...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280100263

    authors： Layton D,Clark DW,Pearce GL,Shakir SA

    更新日期：2001-05-01 00:00:00

  • Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels.

    abstract：OBJECTIVE:The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients. METHODS:Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinica...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0388-z

    authors： Badiou S,Breton H,Peyriere H,Charasson V,Crespel A,Gelisse P,Cristol JP,Hillaire-Buys D

    更新日期：2008-01-01 00:00:00

  • Possible mechanisms of anti-cholinergic drug-induced bradycardia.

    abstract：:Atropine-induced bradycardia is traditionally ascribed to central vagal stimulation, although bradycardia has also been observed after administration of quarternary amines. Pirezepine, a selective M1-antagonist, causes bradycardia in therapeutic doses for which a peripheral mechanism is postulated. This hypothesis has...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558245

    authors： Meyer EC,Sommers DK

    更新日期：1988-01-01 00:00:00

  • Measurement of 5-fluorouracil in scalp hair: a possible index of patient compliance with oral adjuvant chemotherapy.

    abstract：OBJECTIVE:Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050077

    authors： Uematsu T,Nakashima M,Fujii M,Hamano K,Yasutomi M,Kodaira S,Kato T,Kotake K,Oka H,Masuike T

    更新日期：1996-01-01 00:00:00

  • Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex.

    abstract：OBJECTIVE:The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050386

    authors： Piguet V,Desmeules J,Dayer P

    更新日期：1998-01-01 00:00:00

  • Risk factors for vancomycin nephrotoxicity and time course of renal function during vancomycin treatment.

    abstract：PURPOSE:Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over t...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02648-7

    authors： Hirai T,Hanada K,Kanno A,Akashi M,Itoh T

    更新日期：2019-06-01 00:00:00

  • Drug prescription in diabetic patients in Stockholm in 1992 and 1995--change over time.

    abstract：OBJECTIVE:To describe and compare the distribution of prescribed drugs in diabetic patients between 1992 and 1995. METHODS:Two cross-sectional surveys of a random selection of medical records of diabetic patients, from three community health centres (CHCs) in the Stockholm metropolitan area, were carried out. The age ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050285

    authors： Wändell PE,Brorsson B,Aberg H

    更新日期：1997-01-01 00:00:00

  • Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment.

    abstract：:The effect of long-term treatment on the absorption and disposition of metoprolol has been evaluated in 8 healthy, non-smoking, elderly individuals (mean age 74.5 years) and in a control group of 8 healthy, young individuals. Two trace doses of [3H]metoprolol were given i.v., first concomitantly with a single oral 50 ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00544048

    authors： Larsson M,Landahl S,Lundborg P,Regårdh CG

    更新日期：1984-01-01 00:00:00

  • Regional distribution of beta 1- and beta 2-adrenoceptors in the failing and nonfailing human heart.

    abstract：:Total beta-adrenoceptor density and beta 1- and beta 2-subtype distribution in right and left atria and in different ventricular regions from 14 failing and seven nonfailing human hearts have been compared. End-stage heart failure was due to idiopathic dilated cardiomyopathy (n = 8) or ischaemic cardiomyopathy (n = 6)...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00265923

    authors： Steinfath M,Lavicky J,Schmitz W,Scholz H,Döring V,Kalmár P

    更新日期：1992-01-01 00:00:00

  • Accumulation of pinacidil N-oxide during chronic treatment with pinacidil.

    abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00555515

    authors： McBurney A,Henry JA,Ward JW

    更新日期：1988-01-01 00:00:00

  • Comparison of parameters of in vitro lymphocyte beta 2-adrenoceptor function in normal and asthmatic subjects.

    abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315310

    authors： Newnham DM,Coutie WJ,McFarlane LC,Lipworth BJ

    更新日期：1993-01-01 00:00:00

  • Protein binding of drugs in plasma, interstitial fluid and tissues: effect on pharmacokinetics.

    abstract：:Drug binding in the interstitial fluid as well as in the plasma must be taken into account when considering the pharmacokinetics of drugs which are highly bound to plasma proteins and have a relatively small apparent volume of distribution (V). The half-life and apparent volume of distribution of such a drug can be af...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00609592

    authors： Faed EM

    更新日期：1981-01-01 00:00:00

  • What have the ACE-inhibitor trials in postmyocardial patients with left ventricular dysfunction taught us?

    abstract：:A series of elegant experimental studies and careful clinical observation over a decade or more have led to the concept of 'infarct expansion' and 'remodelling' of the heart, culminating in a number of major mortality studies indicating the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in patients af...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Reynolds G,Hall AS,Ball SG

    更新日期：1996-01-01 00:00:00

  • Comparative study of the cardiac and peripheral vascular effects of strophantin K and lanatoside C in coronary heart disease.

    abstract：:The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the l...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00613426

    authors： Matos L,Békés M,Polák G,Rausch J,Török E

    更新日期：1975-10-10 00:00:00

  • Pharmacokinetics in renally impaired subjects of NXY-059, a nitrone-based, free-radical trapping agent developed for the treatment of acute stroke.

    abstract：OBJECTIVE:NXY-059 is a nitrone-based, free-radical trapping agent being developed for the treatment of acute ischaemic stroke. Elimination of NXY-059 is primarily renal. The objective of the study was to investigate the pharmacokinetics of NXY-059 in subjects with renal impairment. METHODS:Twenty-four subjects with a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-002-0478-x

    authors： Strid S,Borgå O,Edenius C,Jostell KG,Odergren T,Weil A

    更新日期：2002-09-01 00:00:00

  • Variability of beta-blocker pharmacokinetics in young volunteers.

    abstract：:Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young health volunteers. In order to assessed the inter- and intra-subject variability the following pharmacokinetic parameters were compared: AUC0(24), Cmax, tmax and t 1/2. T...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF01061375

    authors： Jack DB,Quarterman CP,Zaman R,Kendall MJ

    更新日期：1982-01-01 00:00:00

  • Population pharmacokinetics of lopinavir in combination with rifampicin-based antitubercular treatment in HIV-infected South African children.

    abstract：PURPOSE:The population pharmacokinetics (PK) of lopinavir in tuberculosis (TB)/human immunodeficiency virus (HIV) co-infected South African children taking super-boosted lopinavir (lopinavir/ritonavir ratio 1:1) as part of antiretroviral treatment in the presence of rifampicin were compared with the population PK of lo...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-010-0847-9

    authors： Elsherbiny D,Ren Y,McIlleron H,Maartens G,Simonsson US

    更新日期：2010-10-01 00:00:00

  • Effect of erythropoiesis-stimulating agents in acute ST-segment elevation myocardial infarction: a systematic review.

    abstract：PURPOSE:Current evidence suggests that erythropoiesis-stimulating agents (ESAs), including erythropoietin and darbepoetin, may have a direct cardio-protective effect. However, randomized controlled trials (RCTs) assessing the efficacy and safety of ESAs in patients with acute ST-segment elevation myocardial infarction ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00228-011-1160-y

    authors： Li J,Xu H,Gao Q,Wen Y

    更新日期：2012-05-01 00:00:00

  • Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.

    abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0269-5

    authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

    更新日期：2007-05-01 00:00:00

  • The effects and side effects of laquinimod for the treatment of multiple sclerosis patients: a systematic review and meta-analysis of clinical trials.

    abstract：PURPOSE:Although studies have shown the efficacy of laquinimod (LAQ) on disease progression in patients with multiple sclerosis (MS), there is some controversy about whether it improves the types of outcomes and side effects. The main purpose of the present study was to systematically review and meta-analyze the effica...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-019-02827-6

    authors： Rouhi F,Mohammadpour Z,Noureini SK,Abbastabar H,Harirchian MH,Bitarafan S

    更新日期：2020-05-01 00:00:00

  • Haemodynamic effects and kinetics of concomitant intravenous disopyramide and atenolol in patients with ischaemic heart disease.

    abstract：:The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00614295

    authors： Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

    更新日期：1986-01-01 00:00:00

  • The scientific basis of rational prescribing. A guide to precision clinical pharmacology based on the WHO 6-step method.

    abstract：BACKGROUND AND METHODS:This opinion paper expanded on the WHO "six-step approach to optimal pharmacotherapy," by detailed exploration of the underlying pharmacological and pathophysiological principles. This exercise led to the identification of a large number of domains of research that should be addressed to make cli...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-03044-2

    authors： Rongen GA,Marquet P,van Gerven JMA,EACPT research working group.

    更新日期：2020-11-18 00:00:00

  • Long-term nicotine substitution after application of a 16-hour nicotine patch in smoking cessation.

    abstract：:The purpose of the study was to examine long-term nicotine substitution and its variability during use of a nicotine patch. In two smoking cessation studies a 16-h nicotine patch, releasing 15 mg nicotine, was applied daily for 16 h over 12 weeks, to 167 smokers. Salivary cotinine was highly correlated with plasma cot...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02280755

    authors： Nørregaard J,Tønnesen P,Simonsen K,Säwe U

    更新日期：1992-01-01 00:00:00

  • Transfer of free and conjugated oxazepam across the human placenta.

    abstract：:Six women, 13 to 16 weeks pregnant, and 12 women at 38 to 40 weeks gestation, received oral oxazepam about 12 h before legal abortion, by hysterotomy in the former and before elective caesarean section in the latter group. The concentrations of free and conjugated oxazepam in maternal and fetal plasma were determined ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00625804

    authors： Kangas L,Erkkola R,Kanto J,Eronen M

    更新日期：1980-04-01 00:00:00