Haemodynamic effects and kinetics of concomitant intravenous disopyramide and atenolol in patients with ischaemic heart disease.

abstract：BACKGROUND:Fexofenadine is the active metabolite of the non-sedating anti-histamine terfenadine. Pre-licensing clinical trials in over 6000 patients suggested it was effective and well tolerated. OBJECTIVE:To assess the tolerability and safety of fexofenadine immediately after its availability on the UK market in Marc...

journal_title：European journal of clinical pharmacology

authors： Craig-McFeely PM,Acharya NV,Shakir SA

更新日期：2001-07-01 00:00:00

abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

journal_title：European journal of clinical pharmacology

authors： Steinijans VW,Diletti E

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To describe the frequency and types of drug-related problems (DRPs) in hospitalised patients, and to identify risk factors for DRPs and the drugs most frequently causing them. METHODS:From May to December 2002, 827 patients from six internal medicine and two rheumatology departments in five hospitals in Norw...

journal_title：European journal of clinical pharmacology

authors： Blix HS,Viktil KK,Reikvam A,Moger TA,Hjemaas BJ,Pretsch P,Vraalsen TF,Walseth EK

更新日期：2004-11-01 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：:In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. ...

journal_title：European journal of clinical pharmacology

authors： Lombardi C,Missale C,De Cotiis R,Spedini C,Pizzoccolo G,Memo M,Albertini A,Spano PF

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety profiles after coadministration of clarithromycin, amoxicillin, and il...

journal_title：European journal of clinical pharmacology

authors： Jin BH,Yoo BW,Park J,Kim JH,Lee JY,Shin JS,Park MS

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：:Intensive monitoring of adverse drug reactions (ADR) in infants and preschool children in the paediatric outpatient unit covering the town of Karlovac (150,000 inhabitants) was performed over a period of three months. Data were obtained by physical examination of children and the history given by their parents. In all...

journal_title：European journal of clinical pharmacology

authors： Cirko-Begović A,Vrhovac B,Bakran I

更新日期：1989-01-01 00:00:00

abstract：:The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (...

journal_title：European journal of clinical pharmacology

authors： Chan GL,Erdmann GR,Gruber SA,Stock P,Chen S,Ascher NL,Canafax DM

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Oncological patients are at increasing risk of QT prolongation, a risk factor for ventricular arrhythmia. We assessed impact and risk factors for corrected QT (QTc) prolongation during multiple-cycle chemotherapy. METHODS:We enrolled 100 outpatients initiating chemotherapy in a university center specializing i...

journal_title：European journal of clinical pharmacology

authors： Diemberger I,Massaro G,Cubelli M,Rubino D,Quercia S,Martignani C,Ziacchi M,Biffi M,Bernardi A,Cacciari N,Zamagni C,Boriani G

更新日期：2015-08-01 00:00:00

abstract：:In 8 healthy subjects the absorption of cimetidine was investigated when given alone, together with 60 ml aluminium/magnesium hydroxide containing antacid (neutralising capacity 26 mmol HCl/10 ml), and together with liquid metoclopramide 14 mg. The antacid significantly (P less than 0.01) reduced the bioavailability (...

journal_title：European journal of clinical pharmacology

authors： Gugler R,Brand M,Somogyi A

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To assess the potential damage to patients from the inappropriate use of placebo. METHODS:Pivotal clinical trials of new drugs were evaluated for the treatment of multiple sclerosis following effective treatment with beta interferons and glatiramer acetate. The differences in the relapse rate between the exp...

journal_title：European journal of clinical pharmacology

authors： Garattini S,Bertelé V,Banzi R

更新日期：2013-03-01 00:00:00

abstract：:Maternal and umbilical serum concentrations of atenolol, a hydrophilic, cardioselective beta-adrenoceptor antagonist, were studied at delivery in seven cases of pregnancy hypertension. The drug had been administered to each patient for at least one week. Atenolol was detected in both maternal and umbilical serum in si...

journal_title：European journal of clinical pharmacology

authors： Melander A,Niklasson B,Ingemarsson I,Liedholm H,Scherstén B,Sjöberg NO

更新日期：1978-11-16 00:00:00

abstract：:The aim of laboratory screening in Phase I is to exclude subjects with subclinical illness, who might be at increased risk in the study, and who might also adversely influence interpretation of the results. A new method for laboratory screening, based on Bayesian probability theory, is proposed, which consists of: 1. ...

journal_title：European journal of clinical pharmacology

authors： Sibille M,Vital Durand D

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

journal_title：European journal of clinical pharmacology

authors： Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

更新日期：2021-01-01 00:00:00

abstract：:1. The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 micrograms pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2. Compared with domperidon...

journal_title：European journal of clinical pharmacology

authors： al-Sereiti MR,Quik RF,Hedges A,Turner P

更新日期：1990-01-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：:The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers i...

journal_title：European journal of clinical pharmacology

authors： Kofahl B,Henke D,Hettenbach A,Mutschler E

更新日期：1993-01-01 00:00:00

abstract：:The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 m...

journal_title：European journal of clinical pharmacology

authors： Mondorf AW,Breier J,Hendus J,Scherberich JE,Mackenrodt G,Shah PM,Stille W,Schoeppe W

更新日期：1978-05-17 00:00:00

abstract：:The effect of a single oral dose of 40 mg xipamide on urinary excretion of Na+, K+, Cl-, Ca2+ and Mg2+ in healthy subjects and in patients with varying degrees of renal impairment was compared with various conventional diuretics. Xipamide caused marked excretion of Na+ and Cl-, whereas the diuretic produced only moder...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Mutschler E

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of phenytoin was studied in 66 epileptic Chinese children and adults. The data were analysed by the population approach, using the non-linear mixed effect model, in the MULTI (ELS) program. There was no age or gender-related effect on either the apparent maximum elimination rate (kmax) or Michaeli...

journal_title：European journal of clinical pharmacology

authors： Chan E,Ti TY,Lee HS

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-ri...

journal_title：European journal of clinical pharmacology

authors： Tsai HH,Lin HW,Chien CR,Li TC

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of benazepril and amlodipine in monotherapy versus in combination with plasma t-PA and PAI-1 activity in hypertensive type-2 diabetic patients. METHODS:After an initial 6-week wash-out, single-blind placebo period, 38 patients, 17 men and 21 females, were rand...

journal_title：European journal of clinical pharmacology

authors： Fogari R,Preti P,Lazzari P,Corradi L,Zoppi A,Fogari E,Mugellini A

更新日期：2003-08-01 00:00:00

abstract：:A randomized multicentre between-patient study comparison has been made of the efficacy and tolerability of cadralazine and prazosin, both administered for 6 weeks to hypertensive patients with a supine diastolic blood pressure (DBP) greater than or equal to 95 mmHg whilst on a beta-adrenoceptor-blocker. The doses of ...

journal_title：European journal of clinical pharmacology

authors： Caponnetto S,Valvo E,Mocarelli P,Alberti D,Savonitto S

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To investigate interindividual variability in response to pain treatment, we characterized postoperative patients for morphine metabolism and for COMT, OPRM1 and UGT2B7 polymorphisms. METHODS:A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OP...

journal_title：European journal of clinical pharmacology

authors： De Gregori M,Garbin G,De Gregori S,Minella CE,Bugada D,Lisa A,Govoni S,Regazzi M,Allegri M,Ranzani GN

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:We sought to quantify the influence of the CYP3A inhibitor erythromycin on the pharmacokinetics of everolimus, a CYP3A substrate. METHODS:This was a two-period, single-sequence, crossover study in 16 healthy subjects. In period 1, subjects received the reference treatment of a single 2-mg dose of everolimus....

journal_title：European journal of clinical pharmacology

authors： Kovarik JM,Beyer D,Bizot MN,Jiang Q,Shenouda M,Schmouder RL

更新日期：2005-03-01 00:00:00

abstract：:In a double-blind cross-over study bepridil 900 mg followed by 300 mg daily for 11 days was given to 37 insulin (Type I) or non-insulin (Type II)-dependent diabetic patients. It did not modify the metabolic control of the patients as levels of glucose in blood and urine, doses of insulin and oral hypoglycaemic drugs, ...

journal_title：European journal of clinical pharmacology

authors： Husted SE,Pedersen C,Nielsen HK,Apoil E,Nielsen OH,Lindvig K,Krusell LR,Høegholm A

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:The aim of therapeutic regimens using proton pump inhibitors (PPIs) in patients with acid-related diseases is to potently inhibit acid secretion for the full 24 h. However, optimum treatment is still unclear because the pharmacodynamics of PPIs differ among CYP2C19 genotypes and most of the previous studie...

journal_title：European journal of clinical pharmacology

authors： Sugimoto M,Shirai N,Nishino M,Kodaira C,Uotani T,Sahara S,Ichikawa H,Kagami T,Sugimoto K,Furuta T

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To assess the haemodynamic effects of short-term treatment with dofetilide in comparison with sotalol in patients with ischaemic heart disease. METHODS:Twelve patients with ischaemic heart disease and sustained ventricular tachycardia were treated with dofetilide [500 microg twice daily (b.i.d.)] or sotalol ...

journal_title：European journal of clinical pharmacology

authors： Boriani G,Biffi M,Bacchi L,Martignani C,Zannoli R,Butrous GS,Branzi A

更新日期：2002-06-01 00:00:00