Pharmacokinetics of cefoxitin administered by i.v. infusion to patients with a pleural effusion.

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to describe determinants of current and subsequent benzodiazepine use in an elderly population, the Paquid cohort. METHODS:The study was conducted on a cohort of 2,792 community-dwelling subjects 65 years of age or more living in the Gironde department, southwestern France. B...

journal_title：European journal of clinical pharmacology

authors： Fourrier A,Letenneur L,Dartigues JF,Moore N,Bégaud B

更新日期：2001-08-01 00:00:00

abstract：:The dose-response relationship of the new bronchodilator Clenbuterol (NAB 365, Boehringer Ingelheim) was tested in 12 patients with chronic obstructive lung disease. Clenbuterol is a beta-2-sympathicomimetic, from a series of substituted phenylethanolamines, and it is characterised by good absorption and prolonged act...

journal_title：European journal of clinical pharmacology

authors： Tschan M,Perruchoud A,Herzog H

更新日期：1979-04-17 00:00:00

abstract：:The disposition of oral metoprolol was studied in 5 women during the last trimester of pregnancy and 3 to 5 months after delivery. After a single oral dose of 100 mg the individual peak plasma concentration in the pregnant state was only 20-40% of that after pregnancy. The plasma half-lives of metoprolol were about th...

journal_title：European journal of clinical pharmacology

authors： Högstedt S,Lindberg B,Rane A

更新日期：1983-01-01 00:00:00

abstract：:Eighty patients recovering from major operations were investigated to evaluate the influence of naloxone on the analgesic and respiratory depressant properties of buprenorphine. They were randomly assigned to two groups to self-administer either buprenorphine (Group B) or a mixture of buprenorphine and naloxone (fract...

journal_title：European journal of clinical pharmacology

authors： Lehmann KA,Reichling U,Wirtz R

更新日期：1988-01-01 00:00:00

abstract：:Seven healthy women chronically (greater than 6 months) treated with oral contraceptives and 7 age- and weight-matched female controls were studied. Each subject was given 20 mg fluocortolone orally and the plasma concentrations of total and unbound fluocortolone in multiple samples obtained during the following 24 h ...

journal_title：European journal of clinical pharmacology

authors： Legler UF

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate interindividual variability in response to pain treatment, we characterized postoperative patients for morphine metabolism and for COMT, OPRM1 and UGT2B7 polymorphisms. METHODS:A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OP...

journal_title：European journal of clinical pharmacology

authors： De Gregori M,Garbin G,De Gregori S,Minella CE,Bugada D,Lisa A,Govoni S,Regazzi M,Allegri M,Ranzani GN

更新日期：2013-09-01 00:00:00

abstract：:A new data analysis approach, NON-MEM, proposed by Sheiner and Beal, has been employed to estimate the population pharmacokinetic parameters of oral mexiletine in patients treated for arrhythmias. 452 serum concentration measurements in 58 patients were available for analysis. 27 patients had congestive heart failure ...

journal_title：European journal of clinical pharmacology

authors： Vozeh S,Katz G,Steiner V,Follath F

更新日期：1982-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Lamotrigine as add-on treatment (500 mg per day) is effective in patients with refractory epilepsy, but its high cost requires a pharmacoeconomic analysis. We conducted a retrospective lifetime cost utility study in which clinical data were derived from a recent placebo-controlled clinical trial, cost-of-illn...

journal_title：European journal of clinical pharmacology

authors： Messori A,Trippoli S,Becagli P,Cincotta M,Labbate MG,Zaccara G

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVES:To analyse reports of drug-induced myocardial infarction and chest pain sent to a national reporting centre. To review which drugs were suspected of exhibiting these adverse events and what mechanisms were involved. METHODS:During the 20-year period 1975 through 1994, a total of 19,141 reports on adverse re...

journal_title：European journal of clinical pharmacology

authors： Ottervanger JP,Wilson JH,Stricker BH

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (A...

journal_title：European journal of clinical pharmacology

authors： Levy M,Safadi R,Zylber-Katz E,Granit L,Caraco Y

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To describe and compare the distribution of prescribed drugs in diabetic patients between 1992 and 1995. METHODS:Two cross-sectional surveys of a random selection of medical records of diabetic patients, from three community health centres (CHCs) in the Stockholm metropolitan area, were carried out. The age ...

journal_title：European journal of clinical pharmacology

authors： Wändell PE,Brorsson B,Aberg H

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the cent...

journal_title：European journal of clinical pharmacology

authors： Drago A,Alboni S,Brunello N,De Ronchi D,Serretti A

更新日期：2010-01-01 00:00:00

abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

journal_title：European journal of clinical pharmacology

authors： Vanholder R,De Smet R,Ringoir S

更新日期：1993-01-01 00:00:00

abstract：:The Danish retail pharmacies' drug subsidy system is completely computerized. The data are person-identifiable, making it possible to chart the population's drug use from the perspective of individual users. We decided to explore the potential of this data source and to analyse heavy drug users specifically. The analy...

journal_title：European journal of clinical pharmacology

authors： Hallas J,Nissen A

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00

abstract：:The haemodynamic effects of intravenous metoprolol, over the dose-range 2.5--20 mg, were studied in 12 patients with coronary heart disease. The pharmacodynamic activity of the drug was confirmed by the suppression of exercise systolic pressure and tachycardia. There were statistically significant dose-response reduct...

journal_title：European journal of clinical pharmacology

authors： Hendry WG,Silke B,Taylor SH

更新日期：1981-01-01 00:00:00

abstract：:The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakal...

journal_title：European journal of clinical pharmacology

authors： Ferrier CP,Kurtz A,Lehner P,Shaw SG,Pusterla C,Saxenhofer H,Weidmann P

更新日期：1989-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Sitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes, is reported to be more efficacious in Indian patients than non-Indian patient population. The objective of the study was to evaluate pharmacokinetic and pharmacodynamic (PK/PD) parameters of single-dose sitagli...

journal_title：European journal of clinical pharmacology

authors： Sangle GV,Patil M,Deshmukh NJ,Shengule SA,Kamble S,Vuppalavanchu KK,Kale S,Baig MLA,Singh G,Shaikh J,Tripathi J,Aravindababu P

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:In this review, we focus on the clinical and radiological aspects related to the biological therapy of ankylosing spondylitis (AS), axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). METHODS:A review was carried out in the main medical databases to evaluate the available literature. RESULTS:Even if ...

journal_title：European journal of clinical pharmacology

authors： Maruotti N,Cantatore FP

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The use of surgical antibiotic prophylaxis (SAP) in children is poorly characterized. Our aim was to evaluate the effectiveness of a quality improvement (QI) intervention targeting SAP in children, by means of a multicenter prospective intervention study, with a before and after design. METHODS:We prospectivel...

journal_title：European journal of clinical pharmacology

authors： Ciofi Degli Atti M,Alegiani SS,Raschetti R,Arace P,Giusti A,Spiazzi R,Raponi M,APACHE Study Group.

更新日期：2017-09-01 00:00:00

abstract：:In a cross-over study of six healthy male volunteers, 500 mg theophylline was administered either as plain tablets or in a sustained release preparation. On each occasion 2 g of non-enteric coated sulphasalazine was administered simultaneously as the time of appearance of sulphapyridine, the product of hydrolysis, in ...

journal_title：European journal of clinical pharmacology

authors： Sommers DK,Meyer EC,van Wyk M,Moncrieff J

更新日期：1990-01-01 00:00:00

abstract：:Some physicians regard patients of Geriatric Units as a homogeneous population with respect to digoxin dosage requirements. Others advocate the use of pharmacokinetic models in prescribing digoxin for the elderly. Sixty in-patients of Geriatric Units were studied and the results compared with those previously obtained...

journal_title：European journal of clinical pharmacology

authors： Dobbs RJ,Royston JP,O'Neill CJ,Deshmukh AA,Nicholson PW,Denham MJ,Dobbs SM

更新日期：1987-01-01 00:00:00

abstract：:Cimetropium bromide is an antimuscarinic compound with antispasmodic properties. Its effect on meal-stimulated sigmoid motor activity in 30 patients with the irritable bowel syndrome, mainly with pain and constipation, has been evaluated. The mechanical activity of the sigmoid colon was recorded with a probe with thre...

journal_title：European journal of clinical pharmacology

authors： Lanfranchi GA,Bazzocchi G,Campieri M,Brignola C,Fois F,Imbimbo BP

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The ABCB1 (MDR1) multidrug transporter plays a key role in determining drug bioavailability. Differences in drug response exist among different ethnic groups. However, until now, no haplotype data are available in a Black African population. METHODS:Exons 2, 7, 10, 11, 12, 14, 17, 21, 26, and the surrounding...

journal_title：European journal of clinical pharmacology

authors： Allabi AC,Horsmans Y,Issaoui B,Gala JL

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Pharmacovigilance, defined by the World Health Organisation as 'the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem' plays a key role in ensuring that patients receive safe drugs. Our knowledge of a drug's adverse...

journal_title：European journal of clinical pharmacology

authors： Härmark L,van Grootheest AC

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) w...

journal_title：European journal of clinical pharmacology

authors： Orme M,Sjöqvist F

更新日期：2013-09-01 00:00:00

abstract：:1. The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 micrograms pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2. Compared with domperidon...

journal_title：European journal of clinical pharmacology

authors： al-Sereiti MR,Quik RF,Hedges A,Turner P

更新日期：1990-01-01 00:00:00