Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors.

abstract：PURPOSE:The study aims to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in patients with advanced gastric cancer. METHODS:Five databases were searched up to June 2014, without language restrictions. The outcomes included overall respo...

journal_title：European journal of clinical pharmacology

authors： Xu HB,Huang F,Su R,Shen FM,Lv QZ

更新日期：2015-05-01 00:00:00

abstract：:The pharmacokinetics of the new lipid-lowering drug bezafibrate has been investigated in patients with impaired renal function and hyperlipoproteinaemia. 12 patients received a single oral dose of bezafibrate 300 mg. Plasma and urine samples were collected and bezafibrate was analyzed by gas chromatography. Eight of t...

journal_title：European journal of clinical pharmacology

authors： Anderson P,Norbeck HE

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：:The effects in vitro and in vivo of triiodothyronine on certain functions of human lymphocytes and polymorphonuclear granulocytes have been investigated. Triiodothyronine was able to enhance the phagocytic capacity and chemiluminescent activity of polymorphonuclear granulocytes. PHA-P-induced 3H-thymidine incorporatio...

journal_title：European journal of clinical pharmacology

authors： Balázs C,Leövey A,Szabó M,Bakó G

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：:The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volum...

journal_title：European journal of clinical pharmacology

authors： Else OF,Sorenson H,Edwards IR

更新日期：1978-12-18 00:00:00

abstract：PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

更新日期：2012-06-01 00:00:00

abstract：:In a double-blind, placebo-controlled study nasal saline and histamine provocation tests were performed in patients with perennial allergic rhinitis in order to assess changes in eosinophil influx and non-specific nasal reactivity after 8 days of treatment with ipratropium bromide. A "nasal pool" method was used to tr...

journal_title：European journal of clinical pharmacology

authors： Górski P,Pazdrak K,Ruta U

更新日期：1993-01-01 00:00:00

abstract：:Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

journal_title：European journal of clinical pharmacology

authors： Kakavas S,Demestiha T,Vasileiou P,Xanthos T

更新日期：2011-01-01 00:00:00

abstract：:Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in t...

journal_title：European journal of clinical pharmacology

authors： Augustijns P,Geusens P,Verbeke N

更新日期：1992-01-01 00:00:00

abstract：:A 8.5-month prospective study was performed in the Rhône area of France to study the incidence of infectious diseases in children in day care, and the qualitative and quantitative aspects of drug prescriptions for young children. The families of 1.359 children agreed to participate (98.5% of those selected). During th...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Bossard N,Floret D,Gillet J,Honegger D,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The anti-obesity drug Xenical (orlistat, Roche) was launched on the Swedish market in February 1999. The sales peaked in May 1999 and then declined. The purpose of this study was to investigate the press coverage of Xenical during the period 1998-2000 and, if possible, relate press attention to Xenical sales ...

journal_title：European journal of clinical pharmacology

authors： Brounéus F,Dahlin A,Beermann B

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects. METHODS:A single 5-mg capsule of tropisetron was administered orally to 13 healthy subjects. Plasma concentrations were determined by validated HPLC procedures and data were analyzed by using nonc...

journal_title：European journal of clinical pharmacology

authors： Kim MK,Cho JY,Lim HS,Hong KS,Chung JY,Bae KS,Oh DS,Shin SG,Lee SH,Lee DH,Min B,Jang IJ

更新日期：2003-06-01 00:00:00

abstract：:Red cell folate concentrations were determined in 74 epileptic women in early pregnancy in a prospective study. All patients were treated continuously with antiepileptic drugs since before conception. The most frequently used drugs were carbamazepine (n = 39) and phenytoin (n = 26). Sixty-four patients (86%) were on m...

journal_title：European journal of clinical pharmacology

authors： Tomson T,Lindbom U,Sundqvist A,Berg A

更新日期：1995-01-01 00:00:00

abstract：:The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

journal_title：European journal of clinical pharmacology

authors： Coller JK,Christrup LL,Somogyi AA

更新日期：2009-02-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：:The effects of a 10 day administration of clomipramine (25-50 mg t.i.d.), alprazolam (0.25-0.75 mg t.i.d.) and placebo were assessed in normal volunteers in a double-blind cross-over study. A battery of physiological, psychomotor and cognitive tests was administered both before and 3 h after drug on days 1, 5 and 10. ...

journal_title：European journal of clinical pharmacology

authors： Allen D,Curran HV,Lader M

更新日期：1991-01-01 00:00:00

abstract：:Three groups of patients with biliary tract disease treated by cholecystectomy were given ceftriaxone. In Group 1 single doses of 150 mg and 1500 mg were given on Days 1 and 5 after cholecystectomy. In Group 2 2 g was given daily for 6 days and the cholecystectomy was on Day 2. Patients in Group 3 received 2 g every 1...

journal_title：European journal of clinical pharmacology

authors： Hayton WL,Schandlik R,Stoeckel K

更新日期：1986-01-01 00:00:00

abstract：:Protein binding of phenytoin was assesed in one patient with dialysis encephalopathy before and after haemodialysis. Phenytoin concentrations were measured by radioimmunoassay and continuous ultrafiltration was used to assess phenytoin binding. At a serum concentration of 60 micromol.1-1 the percentage of phenytoin bo...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Lawrence JR,Elliott HL,Whiting B

更新日期：1979-02-19 00:00:00

abstract：OBJECTIVE:We sought to quantify the influence of the CYP3A inhibitor erythromycin on the pharmacokinetics of everolimus, a CYP3A substrate. METHODS:This was a two-period, single-sequence, crossover study in 16 healthy subjects. In period 1, subjects received the reference treatment of a single 2-mg dose of everolimus....

journal_title：European journal of clinical pharmacology

authors： Kovarik JM,Beyer D,Bizot MN,Jiang Q,Shenouda M,Schmouder RL

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:To assess relative roles of the intestinal and hepatic stereoselective metabolism of nicardipine in an oral first-pass disposal with and without grapefruit juice intake. METHODS:The kinetic profiles of (+)- and (-)-nicardipine were studied in the six normal healthy male volunteers who received oral (40 mg) ...

journal_title：European journal of clinical pharmacology

authors： Uno T,Ohkubo T,Sugawara K,Higashiyama A,Motomura S,Ishizaki T

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To study the effect of cisplatin on plasma concentrations and urinary excretion of carnitine in ten patients with different malignancies treated with chemotherapy. METHODS:Carnitine concentrations were determined using a radioenzymatic assay and other metabolites by routine methods of clinical chemistry. Ren...

journal_title：European journal of clinical pharmacology

authors： Heuberger W,Berardi S,Jacky E,Pey P,Krähenbühl S

更新日期：1998-09-01 00:00:00

abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

journal_title：European journal of clinical pharmacology

authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

journal_title：European journal of clinical pharmacology

authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：:Drug utilization was studied in children below 14 years of age in Tenerife, Canary Islands, who were seen as outpatients by 15 paediatricians and 10 general practitioners. Data on diagnosis, previous drug exposure and prescriptions were collected from a random sample of 1327 children. Nose and throat infections (40.1%...

journal_title：European journal of clinical pharmacology

authors： Sanz EJ,Boada JN

更新日期：1988-01-01 00:00:00

abstract：:As a target group, geriataric patients were selected for pharmacokinetic studies with terodiline (Mictrol), an anticholinergic and calcium antagonist drug effective in the treatment of urinary incontinence. The single-dose kinetics in the geriatric patients (mean age 82 years) differed significantly from that previous...

journal_title：European journal of clinical pharmacology

authors： Hallén B,Magnusson A,Bogentoft S,Ekelund P

更新日期：1988-01-01 00:00:00

abstract：:The effect of AS-4370 on gastric emptying was investigated in healthy adults using 99mTc-DTPA. Single doses of AS-4370 2.5, 5 or 10 mg or placebo were administered to 12 subjects in a controlled, double-blind, cross-over study. Tests were performed twice weekly in each subject. Thirty min after administration of test ...

journal_title：European journal of clinical pharmacology

authors： Kanaizumi T,Nakano H,Matsui Y,Ishikawa H,Shimizu R,Park S,Kuriya N

更新日期：1991-01-01 00:00:00

abstract：:Seventeen normotensive, premenopausal women were treated with the 5-hydroxytryptamine-reuptake inhibitor dexfenfluramine 30 mg per day, for 4 days in a randomised double-blind, cross-over, placebo controlled trial. Energy intake was held constant during the study as the aim was to study the endocrine and metabolic eff...

journal_title：European journal of clinical pharmacology

authors： Andersson B,Zimmermann ME,Hedner T,Björntorp P

更新日期：1991-01-01 00:00:00