当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Safety and efficacy of tolcapone in Parkinson's disease: systematic review.

Safety and efficacy of tolcapone in Parkinson's disease: systematic review.

Abstract：

PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarging PD therapeutic armamentarium. METHODS:We searched PubMed for studies on PD patients treated with tolcapone, documenting the following outcomes: liver enzyme, adverse events (AEs), daily Off-time, levodopa daily dose, unified Parkinson's disease rating scale (UPDRS) part-III, quality of life (QoL), and non-motor symptoms. FAERS and EudraVigilance databases for suspected AEs were interrogated for potential additional cases of hepatotoxicity. RESULTS:Thirty-two studies were included, for a total of 4780 patients treated with tolcapone. Pertaining safety, 0.9% of patients showed liver enzyme elevation > 2. Over 23 years, we found 7 cases of severe liver injury related to tolcapone, 3 of which were fatal. All fatal cases did not follow the guidelines for liver function monitoring. FAERS and EudraVigilance database search yielded 61 reports of suspected liver AEs possibly related to tolcapone. Pertaining efficacy, the median reduction of hours/day spent in Off was 2.1 (range 1-3.2), of levodopa was 108.9 mg (1-251.5), of "On" UPDRS-III was 3.6 points (1.1-6.5). Most studies reported a significant improvement of QoL and non-motor symptoms. CONCLUSION:Literature data showed the absence of relevant safety concerns of tolcapone when strict adherence to hepatic function monitoring is respected. Given its high efficacy on motor fluctuations, tolcapone is probably an underutilized tool in the therapeutic PD armamentarium.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

doi

10.1007/s00228-020-03081-x

subject

Has Abstract

pub_date

2021-01-07 00:00:00

eissn

0031-6970

issn

1432-1041

pii

10.1007/s00228-020-03081-x

pub_type

杂志文章,评审

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Comparison of bopindolol and atenolol in chronic stable angina pectoris.

    abstract：:The efficacy of bopindolol and atenolol in the treatment of patients with chronic stable angina pectoris have been compared in a double blind, randomized study. Both bopindolol 1 mg and atenolol 100 mg for 6 weeks increased mean exercise time (25% and 22%, respectively, compared to placebo), time to angina (27% and 25...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00314809

    authors： Fitscha P,Meisner W,Tiso B

    更新日期：1990-01-01 00:00:00

  • Dopamine pharmacokinetics in critically ill newborn infants.

    abstract：:Dopamine is frequently used in critically ill newborn infants for treatment of shock and cardiac failure, but its pharmacokinetics has not been evaluated using a specific analytical method. Steady-state arterial plasma concentrations of dopamine were measured in 11 seriously ill infants receiving dopamine infusion, 5-...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00279976

    authors： Bhatt-Mehta V,Nahata MC,McClead RE,Menke JA

    更新日期：1991-01-01 00:00:00

  • Factors influencing drug protein binding in patients with end stage renal failure.

    abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/BF01428386

    authors： Vanholder R,De Smet R,Ringoir S

    更新日期：1993-01-01 00:00:00

  • Exercise increases plasma concentrations of (R)- and (S)-propranolol.

    abstract：OBJECTIVE:We recently reported a highly stereoselective increase in plasma concentrations of (S)-atenolol during exercise which is most likely due to a release of the drug from adrenergic cells. The objective of the present study was to investigate the influence of physical exercise on plasma concentrations of the (R)-...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050119

    authors： Stoschitzky K,Schumacher M,Stark G,Dimai HP,Stauber R,Stoschitzky P,Krejs GJ,Klein W,Lindner W

    更新日期：1996-01-01 00:00:00

  • Association between low plasma levels of ophthalmic timolol and haemodynamics in glaucoma patients.

    abstract：OBJECTIVES:The aims of the study were to assess the correlation between the plasma concentration of ophthalmic timolol and cardiovascular parameters, and the influence of timolol on advanced haemodynamic variables, such as stroke (SI), cardiac (CI) and systemic vascular resistance (SVRI) indices and arterial pulse wave...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00228-005-0945-2

    authors： Nieminen T,Uusitalo H,Turjanmaa V,Bjärnhall G,Hedenström H,Mäenpää J,Ropo A,Heikkilä P,Kähönen M

    更新日期：2005-07-01 00:00:00

  • Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.

    abstract：OBJECTIVE:UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7 (chromosome 4) nonsynonymous single nucleotide polymorphisms (SNPs) in West African (...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0206-z

    authors： Mehlotra RK,Bockarie MJ,Zimmerman PA

    更新日期：2007-01-01 00:00:00

  • Persistence and treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany.

    abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02627-y

    authors： Kostev K,Jacob L

    更新日期：2019-05-01 00:00:00

  • Adherence to hospital drug formularies and cost of drugs in hospitals in Denmark.

    abstract：PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from indivi...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-013-1540-6

    authors： Plet HT,Hallas J,Kjeldsen LJ

    更新日期：2013-10-01 00:00:00

  • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers.

    abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00199885

    authors： Merkel U,Sigusch H,Hoffmann A

    更新日期：1994-01-01 00:00:00

  • Inhibition of thrombocyte aggregation by oral motapizone and other drugs.

    abstract：:Ten healthy subjects took single oral doses of placebo, 8.8 +/- 1.8 mg motapizone, 40 +/- 13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5 +/- 1.1 mg prazosin in random order, and, as the last preparation 500 mg acetylsalicylic acid. Thrombocyte aggregation induced "ex-vivo" with collagen, ADP and adrena...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00613515

    authors： Schulz V,Fischer W,Hanselle U,Huhmann W,Zietsch V

    更新日期：1986-01-01 00:00:00

  • Effect of renal function on the pharmacokinetics of LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor.

    abstract：PURPOSE:LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor, is indicated for chronic heart failure (HF) and reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization for HF. Following oral administration, LCZ696 provides systemic exposure to valsartan and ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2072-7

    authors： Ayalasomayajula SP,Langenickel TH,Jordaan P,Zhou W,Chandra P,Albrecht D,Pal P,Rajman I,Sunkara G

    更新日期：2016-09-01 00:00:00

  • Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.

    abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0269-5

    authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

    更新日期：2007-05-01 00:00:00

  • Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes.

    abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00614298

    authors： Ajayi AA,Lees KR,Reid JL

    更新日期：1986-01-01 00:00:00

  • Absorption and metabolism in man of 16-epi-gitoxin, a new semi-synthetic cardioactive glycoside.

    abstract：:The pharmacokinetics of 3H-16-epi-gitoxin have been investigated after oral administration: The peak serum level occurred after 30-60 min, and its subsequent decline was in two phases with half-lives of 3.5 and 19.5 h, respectively. Within 3 days 66-70% of the administered radioactivity were eliminated by renal excret...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00562938

    authors： Haustein KO

    更新日期：1977-07-19 00:00:00

  • Intracolonic bioavailability of human calcitonin in man.

    abstract：:Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02285096

    authors： Beglinger C,Born W,Muff R,Drewe J,Dreyfuss JL,Bock A,Mackay M,Fischer JA

    更新日期：1992-01-01 00:00:00

  • Pharmacokinetics and effects on blood pressure of a single oral dose of milrinone in healthy subjects and in patients with renal impairment.

    abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635891

    authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

    更新日期：1986-01-01 00:00:00

  • Effects of cimetropium bromide on gallbladder contraction in response to oral and intraduodenal olive oil.

    abstract：:To evaluate the influence of the stomach and the cholinergic system on gallbladder contraction induced by physiological stimuli, the reduction in gallbladder volume in 7 healthy volunteers has been studied by real-time ultrasonography after the oral and intraduodenal administration of olive oil, preceded by pretreatme...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00315412

    authors： Marzio L,Di Felice F,Celiberti V,Pieramico O,Grossi L,DiGioacchino M,Imbimbo BP,Cuccurullo F

    更新日期：1990-01-01 00:00:00

  • A population pharmacokinetic model to predict oxypurinol exposure in patients on haemodialysis.

    abstract：PURPOSE:The aims of this study were to characterise the population pharmacokinetics of oxypurinol in patients receiving haemodialysis and to compare oxypurinol exposure in dialysis and non-dialysis patients. METHODS:Oxypurinol plasma concentrations from 6 gout people receiving haemodialysis and 19 people with gout not...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-016-2133-y

    authors： Wright DF,Doogue MP,Barclay ML,Chapman PT,Cross NB,Irvine JH,Stamp LK

    更新日期：2017-01-01 00:00:00

  • Impact of histamine type-2 receptor antagonists on the anticancer efficacy of gefitinib in patients with non-small cell lung cancer.

    abstract：PURPOSE:Gefitinib is one of the standard treatments for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor mutations. It has been reported that acid suppressants (AS) decrease the anti-tumor effect of gefitinib by reducing its solubility. AS is sometimes necessary in cancer patients; however, prev...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-03013-9

    authors： Saito Y,Takekuma Y,Kobayashi M,Shinagawa N,Shimizu Y,Kinoshita I,Dosaka-Akita H,Iseki K,Sugawara M

    更新日期：2020-10-07 00:00:00

  • Deprescribing in multi-morbid older people with polypharmacy: agreement between STOPPFrail explicit criteria and gold standard deprescribing using 100 standardized clinical cases.

    abstract：PURPOSE:Older people with advanced frailty are among the highest consumers of medications. When life expectancy is limited, some of these medications are likely to be inappropriate. The aim of this study was to compare STOPPFrail, a concise, easy-to-use, deprescribing tool based on explicit criteria, with gold standard...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-018-2598-y

    authors： Curtin D,Dukelow T,James K,O'Donnell D,O'Mahony D,Gallagher P

    更新日期：2019-03-01 00:00:00

  • The excretion of ketorolac tromethamine into breast milk after multiple oral dosing.

    abstract：:We have studied the transfer of the analgesic ketorolac tromethamine into breast milk in ten women aged between 22 and 35 years. Ketorolac administration was started between 2 and 6 days after delivery. The breast milk was not fed to the infant because of maternal antibiotic use (6 patients) or because of jaundice of ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558080

    authors： Wischnik A,Manth SM,Lloyd J,Bullingham R,Thompson JS

    更新日期：1989-01-01 00:00:00

  • Elevated serum parathyroid hormone concentration during treatment with high ceiling diuretics.

    abstract：:Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was decreased. The ch...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00561397

    authors： Elmgreen J,Tougaard L,Leth A,Christensen MS

    更新日期：1980-10-01 00:00:00

  • Impact of regional copayment policy on selective serotonin reuptake inhibitor (SSRI) consumption and expenditure in Italy.

    abstract：PURPOSE:The continuous growth of antidepressant consumption and expenditure, especially for selective serotonin reuptake inhibitors (SSRIs), has led to the adoption of several policy measures directed toward cost control in Western countries. In Italy, copayment policies have been heterogeneously introduced at a region...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-012-1422-3

    authors： Damiani G,Federico B,Silvestrini G,Bianchi CB,Anselmi A,Iodice L,Ronconi A,Navarra P,Da Cas R,Raschetti R,Ricciardi W

    更新日期：2013-04-01 00:00:00

  • Antipsychotics and Parkinson's disease: association with disease and drug choice during the first 5 years of antiparkinsonian drug treatment.

    abstract：OBJECTIVE:Psychosis is a common complication of the drug treatment of Parkinson's disease (PD). Treatment of this complication is difficult as most antipsychotic drugs worsen motor symptoms of PD. Only the atypical antipsychotic clozapine improves psychosis without worsening of parkinsonism. The aim of the present stud...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-002-0441-x

    authors： van de Vijver DA,Roos RA,Jansen PA,Porsius AJ,de Boer A

    更新日期：2002-05-01 00:00:00

  • Placebo? no thanks, it might be bad for me!

    abstract：OBJECTIVE:To assess the potential damage to patients from the inappropriate use of placebo. METHODS:Pivotal clinical trials of new drugs were evaluated for the treatment of multiple sclerosis following effective treatment with beta interferons and glatiramer acetate. The differences in the relapse rate between the exp...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-012-1383-6

    authors： Garattini S,Bertelé V,Banzi R

    更新日期：2013-03-01 00:00:00

  • Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

    abstract：OBJECTIVE:The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS:We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods w...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-009-0685-9

    authors： Ohno M,Yamamoto A,Ono A,Miura G,Funamoto M,Takemoto Y,Otsu K,Kouno Y,Tanabe T,Masunaga Y,Nonen S,Fujio Y,Azuma J

    更新日期：2009-11-01 00:00:00

  • Comparison of parameters of in vitro lymphocyte beta 2-adrenoceptor function in normal and asthmatic subjects.

    abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315310

    authors： Newnham DM,Coutie WJ,McFarlane LC,Lipworth BJ

    更新日期：1993-01-01 00:00:00

  • Oral therapy with combined enalapril, prazosin and hydrochlorothiazide in the acute treatment of severe hypertension in Nigerians.

    abstract：OBJECTIVE:The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg). PATIENTS:The ages of the patients ranged from...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050158

    authors： Ajayi AA,Afolabi MA,Balogun MO,Adigun AQ,Ajayi OE,Akintomide AO

    更新日期：1996-01-01 00:00:00

  • Absorption of digoxin from the distal parts of the intestine in man.

    abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00614003

    authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

    更新日期：1975-12-19 00:00:00

  • The pharmacokinetic and pharmacodynamic interactions of ramipril with propranolol.

    abstract：:We have studied the pharmacodynamic effects of ramipril, propranolol, and their combination, as well as the effect of propranolol on the pharmacokinetics of ramipril in 12 healthy men (age 24 (SD 6) y, weight 72 (7) kg). Propranolol and placebo, ramipril and placebo, or propranolol and ramipril were given orally for f...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00315392

    authors： van Griensven JM,Seibert-Grafe M,Schoemaker HC,Frölich M,Cohen AF

    更新日期：1993-01-01 00:00:00