Effect of ipratropium on nasal reactivity to histamine and eosinophil influx in perennial allergic rhinitis.

abstract：:Antibiotic cost information was added to the computerized print-out for each patient of microbiology culture results, next to the antibiotic susceptibility list. During the first six months of this addition, the average monthly cost of antibiotics decreased by 16.5% ($7636) compared to the 12 months period preceding t...

journal_title：European journal of clinical pharmacology

authors： Rubinstein E,Barzilai A,Segev S,Samra Y,Modan M,Dickerman O,Haklai C

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：:The relationship between the pharmacokinetics and pharmacodynamics of enoximone, a new positive inotropic agent, was investigated in 6 healthy men. The volunteers received single oral and i.v. doses of 3 and 1 mg/kg, respectively, and placebo in a double-blind cross-over trial. Plasma concentrations of enoximone and i...

journal_title：European journal of clinical pharmacology

authors： Belz GG,Meinicke T,Schäfer-Korting M

更新日期：1988-01-01 00:00:00

abstract：:Oral and sublingual isoxsuprine 20 mg were compared with placebo in double blind randomised cross over trial in 7 patients with Raynaud's phenomenon. Skin thermography, plethysmography of the finger tips and direct temperature measurements showed that sublingual isoxsuprine was slightly but consistently superior to th...

journal_title：European journal of clinical pharmacology

authors： Wesseling H,den Heeten A,Wouda AA

更新日期：1981-01-01 00:00:00

abstract：:A new technique which combines skin microinjection of minute amounts of drugs (0.5 microliter) and measurement of capillary permeability by intravital fluorescence videomicroscopy and densitometry is introduced. Glass micropipettes with a tip diameter of 7-9 microns are inserted by a micromanipulator into the stratum ...

journal_title：European journal of clinical pharmacology

authors： Herrig I,Hoffmann U,Fischer M,Franzeck UK,Bollinger A

更新日期：1996-01-01 00:00:00

abstract：:The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40 +/- 8%, mean +/- SD). A negligible amount (less than 0.2% of the dose) of unchanged drug was re...

journal_title：European journal of clinical pharmacology

authors： Klotz U,Ziegler G,Reimann IW

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to add to the body of evidence on statin-induced gynecomastia based on data retrieved from the Italian spontaneous adverse drug reaction (ADR) reporting database. METHODS:Spontaneous ADR reports collected in the Italian database up to 31 December 2010 were assessed on a case-by-case b...

journal_title：European journal of clinical pharmacology

authors： Roberto G,Biagi C,Montanaro N,Koci A,Moretti U,Motola D

更新日期：2012-06-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans. METHODS:We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP...

journal_title：European journal of clinical pharmacology

authors： Minami H,Yasu T,Tagawa T,Yamakawa K,Ueda S

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients. METHODS:Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinica...

journal_title：European journal of clinical pharmacology

authors： Badiou S,Breton H,Peyriere H,Charasson V,Crespel A,Gelisse P,Cristol JP,Hillaire-Buys D

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：:The interaction between isofezolac and probenecid has been studied with the aid of a specific HPLC assay for isofezolac in plasma and urine. 8 healthy adult volunteers received a single 40 mg oral dose of isofezolac before and after 3 days of loading with 0.5 probenecid t.i.d. There was an increase in the maximum plas...

journal_title：European journal of clinical pharmacology

authors： Bannier A,Comet F,Soubeyrand J,Brazier JL,Chauliac F

更新日期：1985-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：:The effect of the GABAergic drug sodium valproate (SV) on the exercise-induced release of growth hormone (GH) was investigated in 10 healthy males. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. SV 600 mg blunted the increase in GH induced by the exercise, suggesting GABA...

journal_title：European journal of clinical pharmacology

authors： Steardo L,Iovino M,Monteleone P,Agrusta M,Orio F

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:To study the frequency of corticosteroid therapy and the use of inpatient care for preschool children with wheezing in two regions in Finland. METHODS:The Finnish Social Insurance Institution database on refundable asthma medication indicated that 1.18% of children in Tampere and 2.37% in Turku used inhaled...

journal_title：European journal of clinical pharmacology

authors： Csonka P,Mertsola J,Klaukka T,Kaila M,Ståhlberg MR,Ashorn P

更新日期：2000-11-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVE:The ABCB1 (MDR1) multidrug transporter plays a key role in determining drug bioavailability. Differences in drug response exist among different ethnic groups. However, until now, no haplotype data are available in a Black African population. METHODS:Exons 2, 7, 10, 11, 12, 14, 17, 21, 26, and the surrounding...

journal_title：European journal of clinical pharmacology

authors： Allabi AC,Horsmans Y,Issaoui B,Gala JL

更新日期：2005-04-01 00:00:00

abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

journal_title：European journal of clinical pharmacology

authors： McBurney A,Henry JA,Ward JW

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-ri...

journal_title：European journal of clinical pharmacology

authors： Tsai HH,Lin HW,Chien CR,Li TC

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in ongoing efforts to optimise dosage recommendations in clinical practise. This study was performed to further identify the cytochrome P(450) (CYP) enzymes that metabolise major APDs and evaluate the possibility of predicting in vi...

journal_title：European journal of clinical pharmacology

authors： Li XQ,Björkman A,Andersson TB,Gustafsson LL,Masimirembwa CM

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined the influence of the CYP2D6*10 allele on MX pharmacokinetic...

journal_title：European journal of clinical pharmacology

authors： Otani M,Fukuda T,Naohara M,Maune H,Senda C,Yamamoto I,Azuma J

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of oxidoinflammatory injury. Some reports denote alterations in the effectiveness of ACE inhibitors in association with ACE insertion/deletion (I/D) gene polymorphisms. T...

journal_title：European journal of clinical pharmacology

authors： Urhan Küçük M,Sucu N,Şahan Firat S,Aytaçoğlu BN,Vezir Ö,Bozali C,Canacankatan N,Kul S,Tunçtan B

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

journal_title：European journal of clinical pharmacology

authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and ...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakashima M,Fujii M,Hamano K,Yasutomi M,Kodaira S,Kato T,Kotake K,Oka H,Masuike T

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS:One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical reco...

journal_title：European journal of clinical pharmacology

authors： Mannheimer B,Ulfvarson J,Eklöf S,Bergqvist M,von Bahr C

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation. METHOD...

journal_title：European journal of clinical pharmacology

authors： Belpaire FM,Wijnant P,Temmerman A,Rasmussen BB,Brøsen K

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

journal_title：European journal of clinical pharmacology

authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:To determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation of proguanil (PG) to its active antifol triazine metabolite cycloguanil (CG). METHODS:Case control study conducted on the NW border of Thailand; a single dose of PG (4 mg/kg) was administer...

journal_title：European journal of clinical pharmacology

authors： McGready R,Stepniewska K,Seaton E,Cho T,Cho D,Ginsberg A,Edstein MD,Ashley E,Looareesuwan S,White NJ,Nosten F

更新日期：2003-10-01 00:00:00

abstract：:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and ...

journal_title：European journal of clinical pharmacology

authors： Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To investigate the impact of valproic acid (VPA) and genetic polymorphism of the major metabolizing enzyme (UGT1A4, UGT2B7) of lamotrigine (LTG) and VPA on LTG concentration in Chinese epileptic children. METHODS:Three single nucleotide polymorphisms (UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2) were analyzed by p...

journal_title：European journal of clinical pharmacology

authors： Liu L,Zhao L,Wang Q,Qiu F,Wu X,Ma Y

更新日期：2015-11-01 00:00:00