The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries.

abstract：PURPOSE:Alcohol dependence is a public health problem worldwide, commonly associated with withdrawal symptoms for which diazepam is a frequently used drug. We studied the effect of CYP2C19 gene polymorphisms on diazepam loading dose requirement and time to reversal of acute alcohol withdrawal symptoms. We also studied ...

journal_title：European journal of clinical pharmacology

authors： Jose M,Mathaiyan J,Kattimani S,Adithan S,Chandrasekaran A

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Development of safe and effective rescue regimens for eradication failure of Helicobacter pylori infection by standard regimens is an urgent task. We designed the prospective study to compare the efficacy of two rescue regimens after eradication failure by the standard triple therapy. METHODS:One ...

journal_title：European journal of clinical pharmacology

authors： Shirai N,Sugimoto M,Kodaira C,Nishino M,Ikuma M,Kajimura M,Ohashi K,Ishizaki T,Hishida A,Furuta T

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Gentamicin population pharmacokinetics in newborns were studied with special reference to possible gender effects. METHODS:Steady-state serum levels ( n=139) were obtained from 79 neonates with a mean birth weight of 2.1 kg, mean gestational age of 35.1 weeks and mean age at the time of sampling of 4.2 days....

journal_title：European journal of clinical pharmacology

authors： Botha JH,du Preez MJ,Adhikari M

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:This study aimed to test the applicability and effectiveness of the principles and informed consent form (ICF) template proposed by the Strategic Initiative for Developing Capacity in Ethical Review (SIDCER) across multiple clinical trials involving Thai research participants with various conditions. METHODS:A...

journal_title：European journal of clinical pharmacology

authors： Koonrungsesomboon N,Tharavanij T,Phiphatpatthamaamphan K,Vilaichone RK,Manuwong S,Curry P,Siramolpiwat S,Punchaipornpon T,Kanitnate S,Tammachote N,Yamprasert R,Chanvimalueng W,Kaewkumpai R,Netanong S,Kitipawong P,Sritipsukh

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity. METHODS:In 305 ...

journal_title：European journal of clinical pharmacology

authors： Petersen MS,Halling J,Damkier P,Nielsen F,Grandjean P,Weihe P,Brøsen K

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in ongoing efforts to optimise dosage recommendations in clinical practise. This study was performed to further identify the cytochrome P(450) (CYP) enzymes that metabolise major APDs and evaluate the possibility of predicting in vi...

journal_title：European journal of clinical pharmacology

authors： Li XQ,Björkman A,Andersson TB,Gustafsson LL,Masimirembwa CM

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Carvedilol, a beta-adrenoceptor blocking agent with additional alpha(1)-adrenoceptor blocking properties, has been shown to improve left ventricular function in chronic heart failure (CHF). However, its effect on mortality has recently been the subject of controversial discussion. The aim of this meta-analysi...

journal_title：European journal of clinical pharmacology

authors： Schmidt BM,Janson CP,Wehling M

更新日期：1998-06-01 00:00:00

abstract：:A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the met...

journal_title：European journal of clinical pharmacology

authors： Mårtensson J,Denneberg T,Kågedal B

更新日期：1986-01-01 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals. METHODS:In the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde...

journal_title：European journal of clinical pharmacology

authors： Yang TL,Chen MF,Xia X,Luo BL,Li YJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:The anti-obesity drug Xenical (orlistat, Roche) was launched on the Swedish market in February 1999. The sales peaked in May 1999 and then declined. The purpose of this study was to investigate the press coverage of Xenical during the period 1998-2000 and, if possible, relate press attention to Xenical sales ...

journal_title：European journal of clinical pharmacology

authors： Brounéus F,Dahlin A,Beermann B

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 ...

journal_title：European journal of clinical pharmacology

authors： Oliveira-Paula GH,Coeli-Lacchini FB,Ferezin LP,Ferreira GC,Pinheiro LC,Paula-Garcia WN,Garcia LV,Tanus-Santos JE,Lacchini R

更新日期：2021-01-07 00:00:00

abstract：OBJECTIVES:To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS:Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) ...

journal_title：European journal of clinical pharmacology

authors： Kuoppamäki M,Korpela K,Marttila R,Kaasinen V,Hartikainen P,Lyytinen J,Kaakkola S,Hänninen J,Löyttyniemi E,Kailajärvi M,Ruokoniemi P,Ellmén J

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Drug-related problems (DRPs) are common in paediatric pharmacotherapy, but few studies describe them from the parents' perspective. In the present survey, we have investigated the lifetime prevalence and type of DRPs in children in Finland. METHODS:This was a population-based survey of a random sample of 6,000...

journal_title：European journal of clinical pharmacology

authors： Lindell-Osuagwu L,Sepponen K,Farooqui S,Kokki H,Hämeen-Anttila K,Vainio K

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

更新日期：2012-06-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To investigate the distribution of plasma apixaban levels and their relationships with clinical outcomes in elderly patients with atrial fibrillation (AF). METHOD:The J-ELD AF Registry is a multicenter prospective observational study of Japanese non-valvular AF patients aged ≥75 years taking an on-label dose o...

journal_title：European journal of clinical pharmacology

authors： Suzuki S,Yamashita T,Akao M,Okumura K,J-ELD AF investigators.

更新日期：2020-08-01 00:00:00

abstract：:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the uri...

journal_title：European journal of clinical pharmacology

authors： Olsen H,Bredesen JE,Lunde PK

更新日期：1983-01-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：:The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40 +/- 8%, mean +/- SD). A negligible amount (less than 0.2% of the dose) of unchanged drug was re...

journal_title：European journal of clinical pharmacology

authors： Klotz U,Ziegler G,Reimann IW

更新日期：1984-01-01 00:00:00

abstract：:The aim of this multicentre randomised double blind study was to compare the efficacy and safety of the 200-300 mg sustained release diltiazem formulation administered once daily (200-300 SR) with standard diltiazem (D) given three or four times daily to patients with stable angina. Patients aged 59 years, with a repr...

journal_title：European journal of clinical pharmacology

authors： Trimarco B,Radzik D,Van Mieghem W,Neveux E,Wajman A,Attali P,Ponsonnaille J

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

journal_title：European journal of clinical pharmacology

authors： Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

更新日期：2005-05-01 00:00:00

abstract：:The immediate haemodynamic and metabolic effects of acute dose of diazoxide 300 mg i.v. were studied in six healthy subjects at rest and during dynamic forearm exercise. Control periods of rest, exercise and recovery were compared with corresponding periods after drug administration. Resting forearm blood flow was alm...

journal_title：European journal of clinical pharmacology

authors： Hartling OJ,Svendsen TL,Trap-Jensen J

更新日期：1982-01-01 00:00:00

abstract：:In Belgium, all dispensed drugs are provided with package inserts. Traditional physician-orientated inserts are gradually being replaced by patient package inserts (PPIs). The present survey is focused on the use of inserts for antihypertensive drugs and their impact on the reported occurrence and attribution of adver...

journal_title：European journal of clinical pharmacology

authors： Van Haecht CH,Vander Stichele R,Bogaert MG

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...

journal_title：European journal of clinical pharmacology

authors： Newnham DM,Coutie WJ,McFarlane LC,Lipworth BJ

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Spinal-cord injury (SCI) is a leading cause of neuropathic pain (NP). Current pharmaceutical treatments for NP in SCI patients are not effective. Two promising options are gabapentin (GP) and pregabalin (PB). Their predominant mechanism of action is believed to be the inhibition of calcium currents, leading ...

journal_title：European journal of clinical pharmacology

authors： Tzellos TG,Papazisis G,Amaniti E,Kouvelas D

更新日期：2008-09-01 00:00:00