The EU(7)-PIM list: a list of potentially inappropriate medications for older people consented by experts from seven European countries.

abstract：PURPOSE:As an inhibitor of HMG-CoA reductase that catalyses the first step of cholesterol synthesis, pitavastatin undergoes little hepatic metabolism; however, it is a substrate of uptake and efflux transporters. Since pitavastatin is potentially co-administered with agents that affect transporter activities, the pharm...

journal_title：European journal of clinical pharmacology

authors： Chen Y,Zhang W,Huang WH,Tan ZR,Wang YC,Huang X,Zhou HH

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast induced renal vasoconstriction is believed to play a pivotal role in the CMN mechanism. The aim of this pilot study was to examine the safety and efficacy of two d...

journal_title：European journal of clinical pharmacology

authors： Spargias K,Adreanides E,Giamouzis G,Karagiannis S,Gouziouta A,Manginas A,Voudris V,Pavlides G,Cokkinos DV

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

journal_title：European journal of clinical pharmacology

authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from indivi...

journal_title：European journal of clinical pharmacology

authors： Plet HT,Hallas J,Kjeldsen LJ

更新日期：2013-10-01 00:00:00

abstract：:The aim of the study was to examine the effect of chronic angiotensin converting enzyme inhibition on haemodynamics and left ventricular performance during long-lasting exercise at the anaerobic threshold. For this purpose exercise haemodynamics and left ventricular performance were assessed in 14 physically trained h...

journal_title：European journal of clinical pharmacology

authors： Palatini P,Bongiovi S,Mario L,Mormino P,Raule G,Pessina AC

更新日期：1995-01-01 00:00:00

abstract：:The effects of a 10 day administration of clomipramine (25-50 mg t.i.d.), alprazolam (0.25-0.75 mg t.i.d.) and placebo were assessed in normal volunteers in a double-blind cross-over study. A battery of physiological, psychomotor and cognitive tests was administered both before and 3 h after drug on days 1, 5 and 10. ...

journal_title：European journal of clinical pharmacology

authors： Allen D,Curran HV,Lader M

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the effect of 7 days treatment with nimesulide on bleeding time. Blood coagulation, von Willebrand factor and platelet aggregation ex vivo were investigated as a secondary objective. METHOD:A randomised, double-blind, placebo-controlled, parallel group, single centre stu...

journal_title：European journal of clinical pharmacology

authors： Marbet GA,Yasikoff Strub ML,Macciocchi A,Tsakiris DA

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

journal_title：European journal of clinical pharmacology

authors： Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

更新日期：2020-11-11 00:00:00

abstract：OBJECTIVE:To assess the pharmacokinetics, safety and tolerability of escalating oral doses of GW420867X, a non-nucleoside reverse transcriptase inhibitor, was investigated in healthy male volunteers in a randomized, double-blind placebo-controlled study. METHODS:Study subjects were divided into four groups of 12 subje...

journal_title：European journal of clinical pharmacology

authors： Moore KH,Cass LM,Dallow N,Hardman TC,Jones A,Boyce M,Prince WT

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

journal_title：European journal of clinical pharmacology

authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:In a double blind, randomised, placebo-controlled, cross-over study 12 healthy male volunteers were allocated to receive felodipine + placebo, cyclosporine + placebo, and felodipine + cyclosporine in order to investigate the interaction between the calcium channel blocker felodipine and cyclosporine as it aff...

journal_title：European journal of clinical pharmacology

authors： Madsen JK,Jensen JD,Jensen LW,Pedersen EB

更新日期：1996-01-01 00:00:00

abstract：:We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjec...

journal_title：European journal of clinical pharmacology

authors： Takabatake T,Ohta H,Yamamoto Y,Ishida Y,Hara H,Nakamura S,Ushiogi Y,Satoh S,Hattori N

更新日期：1986-01-01 00:00:00

abstract：:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and ...

journal_title：European journal of clinical pharmacology

authors： Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

更新日期：1990-01-01 00:00:00

abstract：:The aim of laboratory screening in Phase I is to exclude subjects with subclinical illness, who might be at increased risk in the study, and who might also adversely influence interpretation of the results. A new method for laboratory screening, based on Bayesian probability theory, is proposed, which consists of: 1. ...

journal_title：European journal of clinical pharmacology

authors： Sibille M,Vital Durand D

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To investigate the drug interaction potential between itraconazole and nevirapine. METHODS:Our study was conducted in 12 healthy volunteers in two phases. In phase 1 (from days 1-28), all subjects were randomly assigned to a two-way crossover study of a nevirapine regimen (nevirapine 200 mg once daily for 7 ...

journal_title：European journal of clinical pharmacology

authors： Jaruratanasirikul S,Sriwiriyajan S

更新日期：2007-05-01 00:00:00

abstract：:Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific a...

journal_title：European journal of clinical pharmacology

authors： Gikalov I,Bircher J

更新日期：1977-11-14 00:00:00

abstract：PURPOSE:Concomitant treatment with the glucose-lowering drug metformin and the platelet aggregation inhibitor dipyridamole often occurs in patients with type 2 diabetes mellitus who have suffered a cerebrovascular event. The gastrointestinal uptake of metformin is mediated by the human equilibrative nucleoside transpor...

journal_title：European journal of clinical pharmacology

authors： El Messaoudi S,Russel FG,Colbers A,Bandell CC,van den Broek PH,Burger DM,Rongen GA,Riksen NP

更新日期：2016-06-01 00:00:00

abstract：:All forensic autopsy cases in southern Sweden in 1986-89 in which antidepressant drugs were found in the blood were assessed and the findings related to the sales of antidepressants as expressed as defined daily doses per 1,000 inhabitants per day. There was a total of 272 antidepressant-positive cases, which were div...

journal_title：European journal of clinical pharmacology

authors： Malmvik J,Löwenhielm CG,Melander A

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. METHODS:Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morni...

journal_title：European journal of clinical pharmacology

authors： Zaidenstein R,Dishi V,Gips M,Soback S,Cohen N,Weissgarten J,Blatt A,Golik A

更新日期：1998-06-01 00:00:00

abstract：:Oxitropium bromide (OXBR) is a new anticholinergic drug, which is expected to be useful in the treatment of nocturnal asthma. The only pharmacokinetic data were obtained with the 14C-labelled compound. A sensitive radioreceptor assay for the determination of unlabelled OXBR in plasma was developed, based on competitio...

journal_title：European journal of clinical pharmacology

authors： Ensing K,de Zeeuw RA,in 't Hout WG,Cornelissen PJ

更新日期：1989-01-01 00:00:00

abstract：:Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

journal_title：European journal of clinical pharmacology

authors： Kakavas S,Demestiha T,Vasileiou P,Xanthos T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To study the effects of possible interactions between levosimendan and warfarin on pharmacokinetics and pharmacodynamics. Furthermore, the effects of levosimendan on blood coagulation were investigated. METHODS:Open, randomised cross-over design with two treatment phases was used. During one phase, levosimen...

journal_title：European journal of clinical pharmacology

authors： Antila S,Jarvinen A,Honkanen T,Lehtonen L

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity. METHODS:In 305 ...

journal_title：European journal of clinical pharmacology

authors： Petersen MS,Halling J,Damkier P,Nielsen F,Grandjean P,Weihe P,Brøsen K

更新日期：2006-12-01 00:00:00

abstract：:Six children, aged 2 months - 4 years, received theophylline 5-6 mg/kg intravenously. Its disposition could be described by a two-compartment open model, the mean serum half life (t 1/2 beta) was 3.75 h, i.e., shorter than in adults, but there was a considerable interindividual variation (1.8-7.0 h, in one patient 13....

journal_title：European journal of clinical pharmacology

authors： Bolme P,Edlund PO,Eriksson M,Paalzow L,Winbladh B

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVES:To identify the frequency of CYP2C9*1, *2 and *3 alleles and the genotype of CYP2C9 gene in the Tamilian population. METHODS:The study was conducted on 135 unrelated healthy human volunteers. DNA was extracted from the peripheral leukocytes samples and was analyzed using the polymerase chain reaction (PCR)-...

journal_title：European journal of clinical pharmacology

authors： Adithan C,Gerard N,Vasu S,Balakrishnan R,Shashindran CH,Krishnamoorthy R

更新日期：2003-11-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：OBJECTIVE:To investigate (1) the pharmacokinetic and pharmacodynamic profiles of desmopressin in men from an age group with a high incidence of nocturia; and (2) circadian variation in the pharmacokinetic parameters. METHODS:The study had an open, randomised, four-way cross-over design. Desmopressin was administered o...

journal_title：European journal of clinical pharmacology

authors： Rembratt A,Graugaard-Jensen C,Senderovitz T,Norgaard JP,Djurhuus JC

更新日期：2004-08-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00