Abstract：
OBJECTIVES:To identify the frequency of CYP2C9*1, *2 and *3 alleles and the genotype of CYP2C9 gene in the Tamilian population. METHODS:The study was conducted on 135 unrelated healthy human volunteers. DNA was extracted from the peripheral leukocytes samples and was analyzed using the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) protocol. The PCR products were digested with AvaII, KpnI or NsiI restriction enzymes. The digested products were separated using 8% polyacrylamide gel and stained by ethidium bromide. Genotyping of the subjects was done based on DNA fragment size. RESULTS:The frequencies of CYP2C9*1, *2 and *3 alleles in the Tamilian population were 0.907, 0.026 and 0.067, respectively. The distribution of CYP2C9*1/*1, *1/*2, *1/*3 and *2/*3 genotypes were 0.823, 0.044, 0.126 and 0.007, respectively. CONCLUSION:CYP2C9*3 is the most frequent mutant allele found in the Tamilian population. The distribution of this mutant allele in the Tamilian population was found to be lesser than in Caucasians but higher than in Chinese.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Adithan C,Gerard N,Vasu S,Balakrishnan R,Shashindran CH,Krishnamoorthy Rdoi
10.1007/s00228-003-0666-3subject
Has Abstractpub_date
2003-11-01 00:00:00pages
707-9issue
8-9eissn
0031-6970issn
1432-1041journal_volume
59pub_type
杂志文章abstract：INTRODUCTION:Reimbursement databases are potentially invaluable tools to develop and conduct pharmacoepidemiological studies on drug use. However, two types of factors that may influence the performance of a database can be distinguished: firstly, factors related to the constitution of the database, and secondly, facto...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00192357
更新日期：1995-01-01 00:00:00
abstract：:The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00605999
更新日期：1982-01-01 00:00:00
abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：BACKGROUND:Triptans are contraindicated in patients with known or suspected coronary artery disease (CAD); however, few studies have evaluated triptans in patients with obstructive CAD to quantify the vasoconstrictive effect on diseased coronary vessels. METHODS:Patients undergoing percutaneous transluminal coronary a...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00609899
更新日期：1983-01-01 00:00:00
abstract：PURPOSE:The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration (Ctrough) within the target range (50-100 mg/L). METHODS:Ninety-eight childre...
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doi：10.1007/s00228-018-2444-2
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,meta分析,评审
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00265923
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s002280050297
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00278481
更新日期：1992-01-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s00228-005-0955-0
更新日期：2005-08-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00265857
更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00228-020-02886-0
更新日期：2020-08-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00614295
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00609885
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00265934
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abstract：:The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 ...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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abstract：:The relationship between the serum protein binding of carbamazepine (CBZ) and carbamazepine-10,11 epoxide (CBZ-E) and the concentration of alpha 1-acid glycoprotein (AAG) and albumin (HSA) was examined in 39 CBZ-treated epileptic children aged 4 months to 12 years. A significant inverse correlation was found between t...
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pub_type： 杂志文章
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
abstract：:Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced o...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00316102
更新日期：1990-01-01 00:00:00
abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00558077
更新日期：1989-01-01 00:00:00
abstract：:Repeated doses of a 1,5 benzodiazepine, clobazam, were administered to a group of consenting volunteers. Performance on a psychomotor performance task was not impaired by repeated doses of the drug. Subjective assessments of anxiety were reduced commensurate with an increase in the level of cortical integration, measu...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/BF00644961
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abstract：:Idrapril is the prototype of a new class of ACE inhibitors, characterised by the presence of a hydroxdmic group. Six untreated in-patients with essential hypertension were given single oral doses of the calcium salt of idrapril, idrapril calcium (200 mg) and placebo according to a double blind, randomised experimental...
journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章,评审
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更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:The extrapolated area under the concentration-time curve (AUC0-infinity) for any drug is considered by operating guidelines as the primary parameter related to the extent of absorption in single-dose bioavailability and bioequivalence trials. Not more than 20% should be added to the experimental AUC (AUC0-t) ...
journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1007/s002280050684
更新日期：1999-11-01 00:00:00
