当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Humoral and haemodynamic effects of idrapril calcium, the prototype of a new class of ACE-inhibitors, in essential hypertensive patients.

Humoral and haemodynamic effects of idrapril calcium, the prototype of a new class of ACE-inhibitors, in essential hypertensive patients.

Abstract：

:Idrapril is the prototype of a new class of ACE inhibitors, characterised by the presence of a hydroxdmic group. Six untreated in-patients with essential hypertension were given single oral doses of the calcium salt of idrapril, idrapril calcium (200 mg) and placebo according to a double blind, randomised experimental design. Supine and upright blood pressure, heart rate, plasma idrapril serum UCE, active renin and angiotensin II were measured at timed intervals for 24 hours after dosing. Plasma idrapril reached a peak after 2 hours (3.01 microgm x ml(-1)), and by 12 hours the compound had almost disappeared (67 ng x ml(-1)). Derived t1/2 was 1.4-2.2 h. ACE activity was suppressed [from 77.9 to 3.3 after 2 hours and 11.8 after 12 hours nmol(-1) x min(-1) x ml] and angiotensin II production inhibited [from 8.8 to 3.1 (after 1 hour) and 7.5 (after 24 hours) pg x ml(-1)]. Compared to placebo, idrapril calcium significantly lowered both supine blood pressure starting at 4 hours (idrapril calcium 140/93 mmHg; placebo 157/101 mmHg; placebo 147/100 mmHg), and upright blood pressure starting at 3 hours (idrapril calcium 135/95 mmHg; placebo 147/100 mmHg) up to 24 hours (idrapril calcium 132/92 mmHg; placebo 145/100 mmHg). Idrapril calcium appears to be an effective ACE inhibitor in essential hypertension, with a hypotensive action for up to 24 h.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Taddei S,Ghiadoni L,Mattei P,Sudano I,Duranti P,Favilla S,Virdis A,Romagnoli A,Criscuoli M,Coppini A

doi

10.1007/BF00194948

subject

Has Abstract,Author List Incomplete

pub_date

1995-01-01 00:00:00

pages

339-43

issue

5

eissn

0031-6970

issn

1432-1041

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories.

    abstract：:Six children, aged 2 months - 4 years, received theophylline 5-6 mg/kg intravenously. Its disposition could be described by a two-compartment open model, the mean serum half life (t 1/2 beta) was 3.75 h, i.e., shorter than in adults, but there was a considerable interindividual variation (1.8-7.0 h, in one patient 13....

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00563120

    authors： Bolme P,Edlund PO,Eriksson M,Paalzow L,Winbladh B

    更新日期：1979-09-01 00:00:00

  • Topical formulations of fluocinolone acetonide. Are creams, gels and ointments bioequivalent and does dilution affect activity?

    abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00195919

    authors： Gao HY,Li Wan Po A

    更新日期：1994-01-01 00:00:00

  • Sublingual and oral isoxsuprine in patients with Raynaud's phenomenon.

    abstract：:Oral and sublingual isoxsuprine 20 mg were compared with placebo in double blind randomised cross over trial in 7 patients with Raynaud's phenomenon. Skin thermography, plethysmography of the finger tips and direct temperature measurements showed that sublingual isoxsuprine was slightly but consistently superior to th...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00615400

    authors： Wesseling H,den Heeten A,Wouda AA

    更新日期：1981-01-01 00:00:00

  • Human pharmacokinetics of nitrazepam: effect of age and diseases.

    abstract：:Plasma concentrations of nitrazepam were measured by gas-liquid chromatography in: young healthy volunteers, in geriatric and psychiatric patients and in epileptic children. The disposition of nitrazepam was described in terms of a two-compartment open model. After a single oral dose of nitrazepam 5 mg the most promin...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00563100

    authors： Kangas L,Iisalo E,Kanto J,Lehtinen V,Pynnönen S,Ruikka I,Salminen J,Sillanpää M,Syvälahti E

    更新日期：1979-04-17 00:00:00

  • The H1-antagonist mequitazine: studies on performance and visual function.

    abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00542129

    authors： Nicholson AN,Stone BM

    更新日期：1983-01-01 00:00:00

  • Distribution and metabolism of N(G)-nitro-L-arginine methyl ester in patients with septic shock.

    abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280050525

    authors： Avontuur JA,Buijk SL,Bruining HA

    更新日期：1998-10-01 00:00:00

  • Hydroxyethyl starch for cardiovascular surgery: a systematic review of randomized controlled trials.

    abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1007/s00228-011-1008-5

    authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

    更新日期：2011-08-01 00:00:00

  • Topical atorvastatin 1% for prevention of skin toxicity in patients receiving radiation therapy for breast cancer: a randomized, double-blind, placebo-controlled trial.

    abstract：BACKGROUND AND PURPOSE:The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer. PATIENTS AND METHODS:Seventy breast cancer patients were ra...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-018-2570-x

    authors： Ghasemi A,Ghashghai Z,Akbari J,Yazdani-Charati J,Salehifar E,Hosseinimehr SJ

    更新日期：2019-02-01 00:00:00

  • Effect of dexfenfluramine treatment on body weight, blood pressure and noradrenergic activity in obese hypertensive patients.

    abstract：:The effect of dexfenfluramine (dF) on body weight, blood pressure and noradrenergic activity were studied in 30 obese hypertensive patients randomly divided into two groups and treated for 3 months either with dF (30 mg daily; 16 subjects) or placebo (Pl; 14 subjects). 11 patients from the dF group and 9 patients give...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00265922

    authors： Kolanowski J,Younis LT,Vanbutsele R,Detry JM

    更新日期：1992-01-01 00:00:00

  • Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus.

    abstract：PURPOSE:The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM). METHODS:Two-hour post-dosing concentrations of RMP, INH and PZA were determined in adult TB patients that were studie...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2132-z

    authors： Kumar AK,Chandrasekaran V,Kannan T,Murali AL,Lavanya J,Sudha V,Swaminathan S,Ramachandran G

    更新日期：2017-01-01 00:00:00

  • The effect of dietary energy and protein deficiency on drug metabolism.

    abstract：:The influence of a diet deficient in energy or protein on hepatic oxidation (Phase I reactions) and glucuronidation (Phase II reactions) in man has been examined. Nine healthy volunteers were fed an energy deficient diet (daily energy intake 4.3 MJ; daily protein intake 0.94 g/kg) and a protein deficient diet (daily e...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00278583

    authors： Hamberg O,Ovesen L,Dorfeldt A,Loft S,Sonne J

    更新日期：1990-01-01 00:00:00

  • Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.

    abstract：:It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three ti...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00567117

    authors： Lökken P,Olsen I,Bruaset I,Norman-Pedersen K

    更新日期：1975-04-04 00:00:00

  • Evaluation of pharmacokinetic interaction between cetirizine and ritonavir, an HIV-1 protease inhibitor, in healthy male volunteers.

    abstract：BACKGROUND:Serious adverse effects have been observed with some non-sedative H1-antihistamines (terfenadine and astemizole) when they were associated with drugs known to inhibit their metabolism. However, this is not a class effect, and this interaction should be considered on a case-by-case basis. The aim of this stud...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-005-0917-6

    authors： Peytavin G,Gautran C,Otoul C,Cremieux AC,Moulaert B,Delatour F,Melac M,Strolin-Benedetti M,Farinotti R

    更新日期：2005-06-01 00:00:00

  • Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.

    abstract：OBJECTIVE:This work aimed at building a population pharmacokinetic (PK) model for lamivudine (LMV), stavudine (STV) and zidovudine (ZDV), estimating their inter and intraindividual PK variability and investigating the influence of different covariates. METHODS:Population PK of LMV, STV and ZDV was separately evaluated...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00228-007-0337-x

    authors： Panhard X,Legrand M,Taburet AM,Diquet B,Goujard C,Mentré F,Cophar 1 - ANRS 102 Study Group.

    更新日期：2007-11-01 00:00:00

  • Drug-associated non-pyrogenic hyperthermia: a narrative review.

    abstract：PURPOSE:Hyperthermia occurs when heat accumulation surpasses the body's ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. METHODS:A comprehensive search was...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00228-019-02763-5

    authors： Bongers KS,Salahudeen MS,Peterson GM

    更新日期：2020-01-01 00:00:00

  • Pharmacokinetics and effects on blood pressure of a single oral dose of milrinone in healthy subjects and in patients with renal impairment.

    abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635891

    authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

    更新日期：1986-01-01 00:00:00

  • Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy.

    abstract：:This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315424

    authors： Peterson GM,Boyle RR,Francis HW,Oliver NW,Paterson J,von Witt RJ,Taylor GR

    更新日期：1990-01-01 00:00:00

  • Improved participants' understanding of research information in real settings using the SIDCER informed consent form: a randomized-controlled informed consent study nested with eight clinical trials.

    abstract：PURPOSE:This study aimed to test the applicability and effectiveness of the principles and informed consent form (ICF) template proposed by the Strategic Initiative for Developing Capacity in Ethical Review (SIDCER) across multiple clinical trials involving Thai research participants with various conditions. METHODS:A...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-016-2159-1

    authors： Koonrungsesomboon N,Tharavanij T,Phiphatpatthamaamphan K,Vilaichone RK,Manuwong S,Curry P,Siramolpiwat S,Punchaipornpon T,Kanitnate S,Tammachote N,Yamprasert R,Chanvimalueng W,Kaewkumpai R,Netanong S,Kitipawong P,Sritipsukh

    更新日期：2017-02-01 00:00:00

  • Pharmacokinetics of methadone in human-immunodeficiency-virus-infected patients receiving nevirapine once daily.

    abstract：:The effect of nevirapine once-daily dosing on the pharmacokinetics of methadone and its main metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, was evaluated in ten HIV positive patients on stable methadone therapy. Nevirapine 200 mg once daily was administered orally from day 1 to day 14. On day 15, nevir...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0299-z

    authors： Arroyo E,Valenzuela B,Portilla J,Climent-Grana E,Pérez-Ruixo JJ,Merino E

    更新日期：2007-07-01 00:00:00

  • Detection and incidence of drug-induced agranulocytosis in hospital: a prospective analysis from laboratory signals.

    abstract：AIMS:Our objectives were to assess the detection and incidence of drug-induced agranulocytosis in two university hospitals using hematology laboratory data. METHODS:A prospective study was undertaken at Toulouse University Hospital (France) and Navarra University Hospital (Spain) for 1 year (from 1 May 2004 to 30 Apri...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0242-8

    authors： Tavassoli N,Duchayne E,Sadaba B,Desboeuf K,Sommet A,Lapeyre-Mestre M,Muoz MJ,Sie P,Honorato J,Montastruc JL,Bagheri H

    更新日期：2007-03-01 00:00:00

  • The use of melatonin in Swedish children and adolescents--a register-based study according to age, gender, and medication of ADHD.

    abstract：PURPOSE:The use of melatonin is increasing among Swedish children and adolescents despite deficient knowledge of usage in these groups. The aim of this study was to investigate the use of melatonin in Swedish children and adolescents according to age, gender, dosage, treatment duration, and use of attention deficit hyp...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1866-3

    authors： Furster C,Hallerbäck MU

    更新日期：2015-07-01 00:00:00

  • Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations.

    abstract：BACKGROUND AND OBJECTIVES:Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with enta...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-014-1701-2

    authors： Rocha JF,Falcão A,Santos A,Pinto R,Lopes N,Nunes T,Wright LC,Vaz-da-Silva M,Soares-da-Silva P

    更新日期：2014-09-01 00:00:00

  • The pharmacokinetics of the beta 2-adrenoceptor agonist, tulobuterol, given transdermally and by inhalation.

    abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00316473

    authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

    更新日期：1993-01-01 00:00:00

  • Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance.

    abstract：:The effect of drinking grapefruit juice on the acute pharmacokinetic and haemodynamic actions of the dihydropyridine calcium antagonist felodipine given as a 5 mg plain tablet has been studied in nine, healthy, middle-aged males. Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00266354

    authors： Edgar B,Bailey D,Bergstrand R,Johnsson G,Regårdh CG

    更新日期：1992-01-01 00:00:00

  • Plasma timolol levels after oral and intravenous administration.

    abstract：:The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volum...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00716385

    authors： Else OF,Sorenson H,Edwards IR

    更新日期：1978-12-18 00:00:00

  • Clinical evidence supporting the marketing authorization of biosimilars in Europe.

    abstract：PURPOSE:To review the marketing authorization of biosimilars and provide a critical analysis of the pivotal trials supporting their approval by the European Medicines Agency (EMA). METHODS:EMA website to identify the biosimilars approved up to July 2019 and the European Public Assessment Report for information on pivo...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00228-019-02805-y

    authors： Allocati E,Bertele' V,Gerardi C,Garattini S,Banzi R

    更新日期：2020-04-01 00:00:00

  • Thiopurine S-methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs.

    abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-004-0728-1

    authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

    更新日期：2004-03-01 00:00:00

  • Psychotropic drug use in nursing homes--diagnostic indications and variations between institutions.

    abstract：OBJECTIVE:Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed. METHODS:A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics,...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280100348

    authors： Ruths S,Straand J,Nygaard HA

    更新日期：2001-09-01 00:00:00

  • A comparison of the bioavailability and potency of dexamethasone phosphate and sulphate in man.

    abstract：:The metabolic fate and ACTH-suppressant activity of two injectable dexamethasone esters, 21-phosphate and 21-sulphate, were studied in healthy men. After i.v. injection of 20mg free steroid alcohol, dexamethasone phosphate was efficiently hydrolyzed to free dexamethasone, reaching its peak plasma concentration within ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00618778

    authors： Miyabo S,Nakamura T,Kuwazima S,Kishida S

    更新日期：1981-01-01 00:00:00

  • Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man.

    abstract：OBJECTIVE:The pharmacokinetics of orally and intravenously administered valsartan were determined in two studies. In a first pilot study, three i.v. doses of valsartan were given in an ascending manner (5, 10 and 20 mg) to evaluate tolerability and basic pharmacokinetics of the i.v. formulation. In a second study, the ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050259

    authors： Flesch G,Müller P,Lloyd P

    更新日期：1997-01-01 00:00:00