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Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man.

Abstract：

:Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced or ADP (0.5-2.0 microM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affect platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperractivity, often observed in these conditions.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Lang CC,Lau CS,Belch JJ,Struthers AD

doi

10.1007/BF00316102

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

589-91

issue

6

eissn

0031-6970

issn

1432-1041

journal_volume

39

pub_type

杂志文章

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