Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials.

abstract：:The bronchodilator activity and side-effects of treatment for 4 days with either 0.085, 0.170 or 0.34 mg/kg bambuterol b.i.d. (a prodrug of terbutaline) or 0.071 mg/kg terbutaline t.i.d. have been evaluated over 12 h, in a double-blind, randomized crossover trial in 19 asthmatic out-patients. Plasma terbutaline concen...

journal_title：European journal of clinical pharmacology

authors： Holstein-Rathlou NH,Laursen LC,Madsen F,Svendsen UG,Gnosspelius Y,Weeke B

更新日期：1986-01-01 00:00:00

abstract：:The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Möhrke W,Mutschler E

更新日期：1983-01-01 00:00:00

abstract：:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single...

journal_title：European journal of clinical pharmacology

authors： Melander O,Lidén A,Melander A

更新日期：1995-01-01 00:00:00

abstract：:Plasma renin concentration (PRC) was measured in 46 patients with essential hypertension before and after treatment for 4 weeks with alprenolol 600-1200 mg daily. In 27 of these patients PRC was measured after 4 weeks of combined treatment with alprenolol and hydralizine. During alprenolol treatment PRC and blood pres...

journal_title：European journal of clinical pharmacology

authors： Pedersen EB,Kornerup HJ

更新日期：1977-10-14 00:00:00

abstract：:The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty ...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Grennan DM,Siddiqui M

更新日期：1983-01-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in seven patients with severe liver disease before and after resolution of ascites. The time to maximum concentration was significantly prolonged by the presence of ascites. Tmax after relief of ascites was similar to that seen for normal volunteers...

journal_title：European journal of clinical pharmacology

authors： Shepherd AN,Bouchier IA

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Body position may influence physiological characteristics, such as perfusion, gastrointestinal function and plasma volume. These characteristics may interact with key factors determining the pharmacokinetics of drugs (dissolution, absorption, distribution, metabolism, excretion). OBJECTIVES:Based on a sys...

journal_title：European journal of clinical pharmacology

authors： Queckenberg C,Fuhr U

更新日期：2009-02-01 00:00:00

abstract：:A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinet...

journal_title：European journal of clinical pharmacology

authors： Takagi K,Kuzuya T,Horiuchi T,Nadai M,Apichartpichean R,Ogura Y,Hasegawa T

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

journal_title：European journal of clinical pharmacology

authors： Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dosing of vancomycin in pediatric patients undergoing continuous venous-venous hemodiafiltration (CVVHDF) is challenging. Characterization of vancomycin pharmacokinetics can assist with dosing and attainment of goal serum concentrations. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS:Patient...

journal_title：European journal of clinical pharmacology

authors： Moffett BS,Morris J,Munoz F,Arikan AA

更新日期：2019-08-01 00:00:00

abstract：:The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (...

journal_title：European journal of clinical pharmacology

authors： Chan GL,Erdmann GR,Gruber SA,Stock P,Chen S,Ascher NL,Canafax DM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7 (chromosome 4) nonsynonymous single nucleotide polymorphisms (SNPs) in West African (...

journal_title：European journal of clinical pharmacology

authors： Mehlotra RK,Bockarie MJ,Zimmerman PA

更新日期：2007-01-01 00:00:00

abstract：:The inhibitory action of azelastine hydrochloride (Azeptin) on the respiratory burst in peripheral polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM) has been studied. Azeptin in vitro suppressed chemiluminescence and superoxide (O2-) generation by human PMN in a dose- and time-dependent manne...

journal_title：European journal of clinical pharmacology

authors： Ueta E,Osaki T,Kawasaki N,Nomura Y

更新日期：1994-01-01 00:00:00

abstract：:Drug binding in the interstitial fluid as well as in the plasma must be taken into account when considering the pharmacokinetics of drugs which are highly bound to plasma proteins and have a relatively small apparent volume of distribution (V). The half-life and apparent volume of distribution of such a drug can be af...

journal_title：European journal of clinical pharmacology

authors： Faed EM

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer. PATIENTS AND METHODS:Seventy breast cancer patients were ra...

journal_title：European journal of clinical pharmacology

authors： Ghasemi A,Ghashghai Z,Akbari J,Yazdani-Charati J,Salehifar E,Hosseinimehr SJ

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:To determine whether patients with idiopathic systemic lupus erythematosus (SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is an association between particular CYP2D6 genotypes and susceptibility to SLE, and whether CYP2D6 polymorphism is linked to any specific clini...

journal_title：European journal of clinical pharmacology

authors： Kortunay S,Bozkurt A,Bathum L,Basci NE,Calgüneri M,Brøsen K,Kayaalp SO

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Tri...

journal_title：European journal of clinical pharmacology

authors： Tracy TS,Krohn K,Jones DR,Bradley JD,Hall SD,Brater DC

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:In this study, the risk factors associated with sodium overcorrection were investigated with an optimal cutoff for baseline serum sodium for use in daily clinical practice. METHODS:Electronic medical records of patients who received tolvaptan for non-hypovolemic hyponatremia were reviewed. Demographic and clin...

journal_title：European journal of clinical pharmacology

authors： Kim Y,Lee N,Lee KE,Gwak HS

更新日期：2020-05-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：OBJECTIVE:To compare the efficacy of activated charcoal and gastric lavage in preventing the absorption of moclobemide, temazepam, and verapamil 30 min after drug ingestion. METHODS:In this randomized cross-over study with three phases, nine healthy volunteers received a single oral dose of 150 mg moclobemide, 10 mg t...

journal_title：European journal of clinical pharmacology

authors： Lapatto-Reiniluoto O,Kivistö KT,Neuvonen PJ

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

journal_title：European journal of clinical pharmacology

authors： Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

更新日期：2020-11-11 00:00:00

abstract：:We have investigated the prevalence of poor metabolisers (PM) of S-mephenytoin in 373 unrelated, healthy Spanish Caucasian subjects, based on the enantiomeric S/R mephenytoin ratio in urine collected 0-8 h and 24-32 h after intake of the racemic drug. Five of the subjects were PM (1.34%, 95% confidence interval 0.18-2...

journal_title：European journal of clinical pharmacology

authors： Reviriego J,Bertilsson L,Carrillo JA,Llerena A,Valdivielso MJ,Benítez J

更新日期：1993-01-01 00:00:00

abstract：:Seven patients with acutely elevated diastolic blood pressure (DBP greater than or equal to 135 mmHg) were treated with repeated injections of diazoxide 1 mg/kg body weight i.v. at 10-min intervals. If the DBP was not reduced to 110 mmHg or less after 5 injections, a dose of 5 mg/kg was given. Serum diazoxide (total a...

journal_title：European journal of clinical pharmacology

authors： McNair A,Andreasen F,Nielsen PE

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：:The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

journal_title：European journal of clinical pharmacology

authors： Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

更新日期：1986-01-01 00:00:00

abstract：:Seventeen patients underwent tonsillectomy 55-120 min after receiving oral phenoxymethylpenicillin 12.5 mg/kg bodyweight. The penicillin concentration in serum and tonsillar tissue in each patient was determined by a microbial assay. In 9 patients with tonsillar hyperplasia, but with no prior history of tonsillitis, t...

journal_title：European journal of clinical pharmacology

authors： Roos K,Brorson JE

更新日期：1990-01-01 00:00:00