2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria.

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：:Atropine-induced bradycardia is traditionally ascribed to central vagal stimulation, although bradycardia has also been observed after administration of quarternary amines. Pirezepine, a selective M1-antagonist, causes bradycardia in therapeutic doses for which a peripheral mechanism is postulated. This hypothesis has...

journal_title：European journal of clinical pharmacology

authors： Meyer EC,Sommers DK

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the cent...

journal_title：European journal of clinical pharmacology

authors： Drago A,Alboni S,Brunello N,De Ronchi D,Serretti A

更新日期：2010-01-01 00:00:00

abstract：:We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjec...

journal_title：European journal of clinical pharmacology

authors： Takabatake T,Ohta H,Yamamoto Y,Ishida Y,Hara H,Nakamura S,Ushiogi Y,Satoh S,Hattori N

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Few data on the efficacy and safety of drugs in children are available as in the past, these children were not included in randomized controlled trials (RCTs). Data on the efficacy and safety of drugs in children are extrapolated from adults. The EMA recognizes the need for long-term safety studies on various d...

journal_title：European journal of clinical pharmacology

authors： Verhamme K,Sturkenboom M

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Carvedilol, a beta-adrenoceptor blocking agent with additional alpha(1)-adrenoceptor blocking properties, has been shown to improve left ventricular function in chronic heart failure (CHF). However, its effect on mortality has recently been the subject of controversial discussion. The aim of this meta-analysi...

journal_title：European journal of clinical pharmacology

authors： Schmidt BM,Janson CP,Wehling M

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:The anti-obesity drug Xenical (orlistat, Roche) was launched on the Swedish market in February 1999. The sales peaked in May 1999 and then declined. The purpose of this study was to investigate the press coverage of Xenical during the period 1998-2000 and, if possible, relate press attention to Xenical sales ...

journal_title：European journal of clinical pharmacology

authors： Brounéus F,Dahlin A,Beermann B

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...

journal_title：European journal of clinical pharmacology

authors： Boscarino C,Edginton AN,Peng H,Riggs KW,Szeitz A,Cheung B

更新日期：2013-01-01 00:00:00

abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

journal_title：European journal of clinical pharmacology

authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to develop a real-time reverse-transcription polymerase chain reaction (RT-PCR) methodology for the quantification of thiopurine methyltransferase (TPMT) gene expression in whole blood and compare it with the TPMT enzyme activity measured in red blood cells. METHODS:TPMT gene...

journal_title：European journal of clinical pharmacology

authors： Lindqvist M,Almer S,Peterson C,Söderkvist P

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：PURPOSE:The present study was carried out to investigate current prescribing and dispensing practices in the largest two teaching hospitals in Sudan and compare them with those of published studies in developing countries. METHODS:A descriptive, quantitative and cross-sectional study was conducted among hospital outpa...

journal_title：European journal of clinical pharmacology

authors： Awad AI,Himad HA

更新日期：2006-12-01 00:00:00

abstract：:The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...

journal_title：European journal of clinical pharmacology

authors： Suzuki T,Higa S,Sakoda S,Ueji M,Hayashi A,Takaba Y,Nakajima A

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Higher drug concentrations in complex clinical scenarios in which multiple factors such as drug-drug interactions (DDIs) and comorbidities are simultaneously present are not necessarily rationalized in prospective clinical studies. Physiologically based pharmacokinetic (PBPK) modeling and simulation of the anti...

journal_title：European journal of clinical pharmacology

authors： Doki K,Kuga K,Aonuma K,Ieda M,Homma M

更新日期：2020-06-01 00:00:00

abstract：:Deuterated methadone (M-d3) and GCMS were used to study the pharmacokinetics of methadone (M) during the induction stage of methadone maintenance treatment (MMT). A pulse dose of M-d3 was given on Days 1 and 25 of two dosage regimens, one with a continuous 30 mg dose (n = 6), and the other with 30 mg for 10 days, foll...

journal_title：European journal of clinical pharmacology

authors： Nilsson MI,Anggård E,Holmstrand J,Gunne LM

更新日期：1982-01-01 00:00:00

abstract：:Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significant...

journal_title：European journal of clinical pharmacology

authors： Schmidt C,Gavoille R,Perez P,Schmitt J

更新日期：1989-01-01 00:00:00

abstract：:Glycerol 50 g infused i.v. over 2 to 6 h is widely used to treat cerebral oedema in patients with acute stroke. Its transit through the blood-cerebrospinal fluid barrier in subjects with uninflamed meninges has now been examined. In 7 patients with an external ventriculostomy for occlusive hydrocephalus, each of whom ...

journal_title：European journal of clinical pharmacology

authors： Nau R,Prins FJ,Kolenda H,Prange HW

更新日期：1992-01-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:A temporal relationship between the increasing use of antibiotics and the increasing levels of antibiotic resistance has been established for Streptococcus pneumoniae. There are also data that support the presence of a geographic correlation between the level of resistance and the pattern of use among differ...

journal_title：European journal of clinical pharmacology

authors： Boccia D,Alegiani SS,Pantosti A,Moro ML,Traversa G

更新日期：2004-04-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：:The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Möhrke W,Mutschler E

更新日期：1983-01-01 00:00:00

abstract：:The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgra...

journal_title：European journal of clinical pharmacology

authors： Moorthi K,Wiederholt K

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

journal_title：European journal of clinical pharmacology

authors： Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

更新日期：2020-11-11 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Our aim was to observe the impact of CYP3A4*1G genetic polymorphism on lipid-lowering efficacy of statins. METHODS:We studied 217 unrelated hyperlipidemic patients who prospectively received atorvastatin and 199 patients who received simvastatin as a single-agent therapy (20 mg day(-1) p.o.) for 4 weeks. Genot...

journal_title：European journal of clinical pharmacology

authors： Gao Y,Zhang LR,Fu Q

更新日期：2008-09-01 00:00:00

abstract：:Ten normal adult tobacco smokers and 10 nonsmoking volunteers 20-31 years of age were the subjects of this study. The tobacco smokers all had a history of daily tobacco smoking. They were asked to stop smoking for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured on different days...

journal_title：European journal of clinical pharmacology

authors： Domino EF,Kadoya C,Matsuoka S

更新日期：1994-01-01 00:00:00

abstract：:A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5 alpha-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Depré M,Schwartz JI,Tjandramaga TB,Winchell GA,De Lepeleire I,Ng J,De Schepper PJ

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To investigate associations between antidepressant use patterns and risk of fatal and non-fatal suicidal behaviours in older adults who initiated antidepressant therapy. METHOD:A national population-based cohort study conducted among Swedish residents aged ≥ 75 years who initiated antidepressant treatment. Pat...

journal_title：European journal of clinical pharmacology

authors： Hedna K,Andersson Sundell K,Hamidi A,Skoog I,Gustavsson S,Waern M

更新日期：2018-02-01 00:00:00