当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics. Results of the 10-year follow-up of the prospective population study "Men born in 1914", Malmo, Sweden.

Increased risk of ischaemic heart disease mortality in elderly men using anxiolytics-hypnotics and analgesics. Results of the 10-year follow-up of the prospective population study "Men born in 1914", Malmo, Sweden.

Abstract：

OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (IHD) mortality. METHODS:Multivariate 10-year survival analysis in a population based cohort of 500 men born in 1914. Relative risks (RR) were adjusted by relevant confounders (blood pressure, serum cholesterol, diabetes mellitus, smoking habit, high alcohol consumption, history of previous IHD, cancer, and other diseases). RESULTS:The RR of both all-cause and IHD mortality were significantly increased among those using both AHD and analgesics compared to those who took neither of these drugs: RR = 1.8 for all-cause mortality, and RR = 2.7 for IHD mortality. CONCLUSION:Although the number of cases was small, warranting interpretative caution, the current study suggests that the combined use of AHD (mainly benzodiazepines) and analgesics seems to be associated with an increase in all-cause and IHD mortality in elderly men.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

doi

10.1007/BF00226325

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

261-5

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

49

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Experimental, extrapolated and truncated areas under the concentration-time curve in bioequivalence trials.

    abstract：OBJECTIVE:The extrapolated area under the concentration-time curve (AUC0-infinity) for any drug is considered by operating guidelines as the primary parameter related to the extent of absorption in single-dose bioavailability and bioequivalence trials. Not more than 20% should be added to the experimental AUC (AUC0-t) ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050684

    authors： Marzo A,Monti NC,Vuksic D

    更新日期：1999-11-01 00:00:00

  • Pharmacokinetics and effects on blood pressure of a single oral dose of milrinone in healthy subjects and in patients with renal impairment.

    abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635891

    authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

    更新日期：1986-01-01 00:00:00

  • A comparative study of the effects of aspirin and paracetamol (acetaminophen) on platelet aggregation and bleeding time.

    abstract：:In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Follo...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00543486

    authors： Seymour RA,Williams FM,Oxley A,Ward A,Fearns M,Brighan K,Rawlins MD,Jones PM

    更新日期：1984-01-01 00:00:00

  • Population pharmacokinetic analysis of vancomycin in pediatric continuous renal replacement therapy.

    abstract：BACKGROUND AND OBJECTIVES:Dosing of vancomycin in pediatric patients undergoing continuous venous-venous hemodiafiltration (CVVHDF) is challenging. Characterization of vancomycin pharmacokinetics can assist with dosing and attainment of goal serum concentrations. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS:Patient...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02664-7

    authors： Moffett BS,Morris J,Munoz F,Arikan AA

    更新日期：2019-08-01 00:00:00

  • Biliary excretion and pharmacokinetics of ceftriaxone after cholecystectomy.

    abstract：:Three groups of patients with biliary tract disease treated by cholecystectomy were given ceftriaxone. In Group 1 single doses of 150 mg and 1500 mg were given on Days 1 and 5 after cholecystectomy. In Group 2 2 g was given daily for 6 days and the cholecystectomy was on Day 2. Patients in Group 3 received 2 g every 1...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00607958

    authors： Hayton WL,Schandlik R,Stoeckel K

    更新日期：1986-01-01 00:00:00

  • Trials, Regulation and tribulations.

    abstract：INTRODUCTION:Regulation EU 536/2014 EU introduces a separation between two parts (technical-scientific aspects and locally relevant ethical aspects) in the assessment of applications for approval of trials and provides for each 'Member State concerned' to arrive at 'one single decision' regarding the application for au...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2009-1

    authors： Petrini C,Garattini S

    更新日期：2016-04-01 00:00:00

  • Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients.

    abstract：OBJECTIVE:The aim of this study was to define the pharmacokinetic profile of free carbamazepine (F-CBZ) in adult Omani epileptic patients in order to improve on dosing schedules through population pharmacokinetic analysis using the NONMEM program. METHOD:Steady-state trough F-CBZ serum concentrations, carbamazepine (C...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280100300

    authors： Deleu D,Aarons L,Ahmed IA

    更新日期：2001-06-01 00:00:00

  • Pharmacokinetic comparison of pindolol 30 mg retard and 15 mg normal tablets.

    abstract：:In a cross-over pharmacokinetic study in 8 healthy volunteers a retard formulation containing pindolol 30 mg was compared with the normal 15 mg. pindolol tablet. The pindolol 30 mg retard tablet led to the same maximum plasma level as a single dose of the normal pindolol tablet. A plasma concentration higher than half...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00542037

    authors： Aellig WH,Nüesch E,Pacha W

    更新日期：1982-01-01 00:00:00

  • Possible mechanisms of anti-cholinergic drug-induced bradycardia.

    abstract：:Atropine-induced bradycardia is traditionally ascribed to central vagal stimulation, although bradycardia has also been observed after administration of quarternary amines. Pirezepine, a selective M1-antagonist, causes bradycardia in therapeutic doses for which a peripheral mechanism is postulated. This hypothesis has...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558245

    authors： Meyer EC,Sommers DK

    更新日期：1988-01-01 00:00:00

  • Acute myocarditis after massive phenelzine overdose.

    abstract：BACKGROUND:Monoamine oxidase inhibitors (MAOIs) are uncommonly used due to their high frequency of adverse effects, including tachycardia and hypertension. Recently, there has been renewed interest in the role of this class of drugs in treating a variety of psychiatric disorders. The clinical features of MAOI overdose ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0360-y

    authors： Waring WS,Wallace WA

    更新日期：2007-11-01 00:00:00

  • Dosage prescribing and plasma oxipurinol levels in patients receiving allopurinol therapy.

    abstract：:This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315424

    authors： Peterson GM,Boyle RR,Francis HW,Oliver NW,Paterson J,von Witt RJ,Taylor GR

    更新日期：1990-01-01 00:00:00

  • Influence of posture on pharmacokinetics.

    abstract：INTRODUCTION:Body position may influence physiological characteristics, such as perfusion, gastrointestinal function and plasma volume. These characteristics may interact with key factors determining the pharmacokinetics of drugs (dissolution, absorption, distribution, metabolism, excretion). OBJECTIVES:Based on a sys...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00228-008-0579-2

    authors： Queckenberg C,Fuhr U

    更新日期：2009-02-01 00:00:00

  • Association of in-hospital intensive statins dosage and death in arteriosclerotic cardiovascular disease with percutaneous coronary intervention: insights of multicentre cohort from China.

    abstract：PURPOSE:In-hospital statin dosage-related effect remains unknown for patients with arteriosclerotic cardiovascular disease (ASCVD). This study aimed to determine the associations of different in-hospital intensive statins dosages with the prognosis for patients in the era of percutaneous coronary intervention (PCI). M...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02966-1

    authors： Chen PY,Liu YH,Duan CY,Fan HL,Zeng LH,Guo W,Jiang L,Wei XB,He WF,Tao S,Guo ZQ,Chen JY,Tan N,He PC

    更新日期：2020-12-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of transdermal dexmedetomidine.

    abstract：:Dexmedetomidine is a novel alpha 2-adrenoceptor agonist that may provide beneficial effects as premedication for anesthesia. The pharmacokinetics and pharmacodynamics of transdermal (TD) and intravenous (i.v.) dexmedetomidine were studied in nine healthy male subjects in a crossover trial. The TD preparation, containi...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00194403

    authors： Kivistö KT,Kallio A,Neuvonen PJ

    更新日期：1994-01-01 00:00:00

  • Effect of loperamide on jejunal electrolyte and water transport, prostaglandin E2-induced secretion and intestinal transit time in man.

    abstract：:Jejunal perfusion was performed in 12 healthy volunteers to evaluate the dose dependent effects of loperamide on intestinal absorption, stimulated secretion and transit. In 6 volunteers intestinal perfusion of the jejunal segment with isotonic NaCl solution was followed by addition of loperamide in increasing doses (2...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315436

    authors： Press AG,Ewe K,Schmidt J,Junge H

    更新日期：1991-01-01 00:00:00

  • The pharmacokinetics of the beta 2-adrenoceptor agonist, tulobuterol, given transdermally and by inhalation.

    abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00316473

    authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

    更新日期：1993-01-01 00:00:00

  • Pharmacokinetic and pharmacodynamic interactions between the novel calcium sensitiser levosimendan and warfarin.

    abstract：OBJECTIVE:To study the effects of possible interactions between levosimendan and warfarin on pharmacokinetics and pharmacodynamics. Furthermore, the effects of levosimendan on blood coagulation were investigated. METHODS:Open, randomised cross-over design with two treatment phases was used. During one phase, levosimen...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280000204

    authors： Antila S,Jarvinen A,Honkanen T,Lehtonen L

    更新日期：2000-12-01 00:00:00

  • Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management.

    abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280100366

    authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

    更新日期：2001-11-01 00:00:00

  • Biperiden effects and plasma levels in volunteers.

    abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00556903

    authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

    更新日期：1984-01-01 00:00:00

  • Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1-48 months.

    abstract：PURPOSE:Until recently, ondansetron was approved for the prevention of nausea and vomiting only in patients older than 2 years. However, as the use of ondansetron in patients younger than 2 years had been documented, characterization of ondansetron pharmacokinetics in this younger pediatric age group was warranted. ME...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00228-009-0730-8

    authors： Mondick JT,Johnson BM,Haberer LJ,Sale ME,Adamson PC,Coté CJ,Croop JM,Russo MW,Barrett JS,Hoke JF

    更新日期：2010-01-01 00:00:00

  • Impact of regional copayment policy on selective serotonin reuptake inhibitor (SSRI) consumption and expenditure in Italy.

    abstract：PURPOSE:The continuous growth of antidepressant consumption and expenditure, especially for selective serotonin reuptake inhibitors (SSRIs), has led to the adoption of several policy measures directed toward cost control in Western countries. In Italy, copayment policies have been heterogeneously introduced at a region...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-012-1422-3

    authors： Damiani G,Federico B,Silvestrini G,Bianchi CB,Anselmi A,Iodice L,Ronconi A,Navarra P,Da Cas R,Raschetti R,Ricciardi W

    更新日期：2013-04-01 00:00:00

  • Surveillance of suspected adverse reactions to herbal products used as laxatives.

    abstract：AIM:To describe and evaluate spontaneous reports of suspected adverse reactions (ARs) associated with herbal laxatives received by the Italian Medicines Agency and the Italian National Institute of Health between April 2002 and January 2011. METHODS:Spontaneous reports of suspected ARs were individually analyzed by a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-011-1128-y

    authors： Vitalone A,Menniti-Ippolito F,Raschetti R,Renda F,Tartaglia L,Mazzanti G

    更新日期：2012-03-01 00:00:00

  • Generalization of distribution--free confidence intervals for bioavailability ratios.

    abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635713

    authors： Steinijans VW,Diletti E

    更新日期：1985-01-01 00:00:00

  • Hair analysis of flecainide for assessing the individual drug-taking behavior.

    abstract：OBJECTIVE:The concentration of flecainide in hair was measured to determine its value as an index of individual drug-taking history. METHODS:Hair samples obtained from 15 patients treated with flecainide for more than 1 month were cut into 1-cm-long portions successively from its scalp end. The concentration of flecai...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-002-0450-9

    authors： Takiguchi Y,Ishihara R,Torii M,Kato R,Kamihara S,Uematsu T

    更新日期：2002-05-01 00:00:00

  • Allele and genotype frequency of CYP2C9 in Tamilnadu population.

    abstract：OBJECTIVES:To identify the frequency of CYP2C9*1, *2 and *3 alleles and the genotype of CYP2C9 gene in the Tamilian population. METHODS:The study was conducted on 135 unrelated healthy human volunteers. DNA was extracted from the peripheral leukocytes samples and was analyzed using the polymerase chain reaction (PCR)-...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-003-0666-3

    authors： Adithan C,Gerard N,Vasu S,Balakrishnan R,Shashindran CH,Krishnamoorthy R

    更新日期：2003-11-01 00:00:00

  • Transfer of free and conjugated oxazepam across the human placenta.

    abstract：:Six women, 13 to 16 weeks pregnant, and 12 women at 38 to 40 weeks gestation, received oral oxazepam about 12 h before legal abortion, by hysterotomy in the former and before elective caesarean section in the latter group. The concentrations of free and conjugated oxazepam in maternal and fetal plasma were determined ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00625804

    authors： Kangas L,Erkkola R,Kanto J,Eronen M

    更新日期：1980-04-01 00:00:00

  • The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients-a randomized, controlled trial.

    abstract：PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02997-8

    authors： Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

    更新日期：2021-01-01 00:00:00

  • The pharmacokinetics of fluconazole during haemodialysis in uraemic patients.

    abstract：:We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount ext...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00265934

    authors： Oono S,Tabei K,Tetsuka T,Asano Y

    更新日期：1992-01-01 00:00:00

  • Hydralazine-induced lupus: is there a toxic metabolic pathway?

    abstract：:The metabolism of hydralazine in a group of slow acetylator patients with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects. There were no toxicologically significant difference in metabolite excretion between the groups which reached statistical significance, although t...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00556891

    authors： Timbrell JA,Facchini V,Harland SJ,Mansilla-Tinoco R

    更新日期：1984-01-01 00:00:00

  • The effects on ventilation of ketorolac in comparison with morphine.

    abstract：:We have compared the effect on ventilation of ketorolac, an injectable non-steroidal analgesic, with that of morphine in a randomized, double-blind, cross-over study, using two doses of ketorolac (10 and 90 mg i.m.) and one of morphine (10 mg i.m.). The effect on ventilation was measured with a CO2 rebreathing techniq...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00558243

    authors： Bravo LJ,Mattie H,Spierdijk J,Bovill JG,Burm AG

    更新日期：1988-01-01 00:00:00