Pharmacokinetic comparison of pindolol 30 mg retard and 15 mg normal tablets.

abstract：PURPOSE:The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS:When prescribing for older pa...

journal_title：European journal of clinical pharmacology

authors： Brewer L,Williams D,Moore A

更新日期：2011-04-01 00:00:00

abstract：:The pharmacokinetics of enprofylline, a new potent antiasthmatic, has been studied in 20 healthy, elderly subjects, aged 65 to 81 years, and in 7 young adult controls, aged 23 to 37 years. The dose of 1 mg/kg body weight was given as an i.v. infusion. Plasma levels of enprofylline were followed for about 7 h and urine...

journal_title：European journal of clinical pharmacology

authors： Lunell E,Borgå O

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Anti-tumor necrosis factor-alpha (TNF-α) agents have considerable advances in treating inflammatory bowel disease (IBD). These drugs carry possible risk of adverse symptoms, and no meta-analysis has examined this issue and the potential duration-response relationship. PURPOSE:The purpose of this study was t...

journal_title：European journal of clinical pharmacology

authors： Wang F,Lin X,Zhao Q,Li J

更新日期：2015-08-01 00:00:00

abstract：:This is the first report of the use of DHM 32-550 a dehydrogenated peptide ergot alkaloid with both alpha and beta adrenoceptor blocking activity, in patients with angina-like chest pain. Five patients were studied to assess a dose/response relationship. No deleterious effects on blood pressure occurred at either rest...

journal_title：European journal of clinical pharmacology

authors： Handler CE,Sowton E

更新日期：1984-01-01 00:00:00

abstract：:The Danish retail pharmacies' drug subsidy system is completely computerized. The data are person-identifiable, making it possible to chart the population's drug use from the perspective of individual users. We decided to explore the potential of this data source and to analyse heavy drug users specifically. The analy...

journal_title：European journal of clinical pharmacology

authors： Hallas J,Nissen A

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS:Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) ...

journal_title：European journal of clinical pharmacology

authors： Kuoppamäki M,Korpela K,Marttila R,Kaasinen V,Hartikainen P,Lyytinen J,Kaakkola S,Hänninen J,Löyttyniemi E,Kailajärvi M,Ruokoniemi P,Ellmén J

更新日期：2009-05-01 00:00:00

abstract：:Encainide is a new anti-arrhythmic drug, which is highly effective against ventricular extrasystoles, both single and coupled, in the dose range of 80--140 mg i.v. Ventricular extrasystoles were abolished in 31 out of 33 cases treated. The drug is also relatively effective against supraventricular extrasystoles, but h...

journal_title：European journal of clinical pharmacology

authors： Kesteloot H,Stroobandt R

更新日期：1979-11-01 00:00:00

abstract：:Plasma concentrations of nitrazepam were measured by gas-liquid chromatography in: young healthy volunteers, in geriatric and psychiatric patients and in epileptic children. The disposition of nitrazepam was described in terms of a two-compartment open model. After a single oral dose of nitrazepam 5 mg the most promin...

journal_title：European journal of clinical pharmacology

authors： Kangas L,Iisalo E,Kanto J,Lehtinen V,Pynnönen S,Ruikka I,Salminen J,Sillanpää M,Syvälahti E

更新日期：1979-04-17 00:00:00

abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

journal_title：European journal of clinical pharmacology

authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

更新日期：2016-05-01 00:00:00

abstract：:To assess the partial agonist activity of cicloprolol in man, four studies were carried out in normal male volunteers. I and II. Open dose escalating studies of the effects of oral doses of the drug on exercise tachycardia and sleeping heart rate. III and IV. Double-blind randomized studies of the effects of placebo, ...

journal_title：European journal of clinical pharmacology

authors： McCaffrey PM,Burke M,Riddell JG,Shanks RG

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain. METHODS:a randomized crossover study design with three phases at int...

journal_title：European journal of clinical pharmacology

authors： Nieminen TH,Hagelberg NM,Saari TI,Neuvonen M,Neuvonen PJ,Laine K,Olkkola KT

更新日期：2010-10-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in seven patients with severe liver disease before and after resolution of ascites. The time to maximum concentration was significantly prolonged by the presence of ascites. Tmax after relief of ascites was similar to that seen for normal volunteers...

journal_title：European journal of clinical pharmacology

authors： Shepherd AN,Bouchier IA

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to determine whether mefenamic acid and salicylic acid inhibit the sulfation of (-)-salbutamol and minoxidil in the human liver and duodenum, and if so, to ascertain whether the 50% inhibitory concentration (IC50) estimates are different in the two tissues. METHODS:Sulfotran...

journal_title：European journal of clinical pharmacology

authors： Vietri M,Pietrabissa A,Spisni R,Mosca F,Pacifici GM

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To quantify pharmacokinetic (PK) and pharmacodynamic (PD) relationships of various classes of GABAA agonists in healthy volunteers, in order to investigate the sensitivity of the biomarker responses due to differing GABAA-subtype selectivity and to explore the correlation between biomarker responses and side ef...

journal_title：European journal of clinical pharmacology

authors： Ren YP,Xie RJ,Marshall S,Li L,Zhou TY,Lu W

更新日期：2015-10-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin and 4'epi-adriamycin have been studied in 6 patients with ovarian carcinoma after simultaneous intravenous administration of equal amounts of the two anthracyclines. A highly selective liquid chromatographic analytical method permitted quantification of plasma concentrations o...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Stendahl U,Lönroth U

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to ascertain acute liver injury (ALI) in primary care databases using different computer algorithms. The aim of this investigation was to study and compare the incidence of ALI in different primary care databases and using different definitions of ALI. METHODS:The Clinical Practic...

journal_title：European journal of clinical pharmacology

authors： Ruigómez A,Brauer R,Rodríguez LA,Huerta C,Requena G,Gil M,de Abajo F,Downey G,Bate A,Tepie MF,de Groot M,Schlienger R,Reynolds R,Klungel O

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge, the pharmacokinetics of epidural hydromorphone has not been evaluated in parturients. MATERIALS AND METHODS:In thi...

journal_title：European journal of clinical pharmacology

authors： Puhto T,Kokki M,Hakomäki H,Spalding M,Gunnar T,Alahuhta S,Vakkala M

更新日期：2020-07-01 00:00:00

abstract：:The binding of propranolol, a drug commonly used in cardiovascular disorders, to alpha 1-acid glycoprotein (AGP) was studied in vitro in malnutrition. Compared to normal and hospital controls, the level of AGP was found to be elevated in undernourished subjects with and without infection. In the same patients the free...

journal_title：European journal of clinical pharmacology

authors： Jagadeesan V,Krishnaswamy K

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The use of surgical antibiotic prophylaxis (SAP) in children is poorly characterized. Our aim was to evaluate the effectiveness of a quality improvement (QI) intervention targeting SAP in children, by means of a multicenter prospective intervention study, with a before and after design. METHODS:We prospectivel...

journal_title：European journal of clinical pharmacology

authors： Ciofi Degli Atti M,Alegiani SS,Raschetti R,Arace P,Giusti A,Spiazzi R,Raponi M,APACHE Study Group.

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:African populations, including the Sudanese, are underrepresented in warfarin pharmacogenetic studies. We designed a study to determine the associations between the polymorphisms and haplotype structures of CYP2C9 and VKORC1 and warfarin dose response in Sudanese patients, one of the most genetically diverse ...

journal_title：European journal of clinical pharmacology

authors： Shrif NE,Won HH,Lee ST,Park JH,Kim KK,Kim MJ,Kim S,Lee SY,Ki CS,Osman IM,Rhman EA,Ali IA,Idris MN,Kim JW

更新日期：2011-11-01 00:00:00

abstract：:The effect of nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes. Forty-three patients (23 in the nomifensin group and 20 in the desimipram...

journal_title：European journal of clinical pharmacology

authors： Acébal E,Subirá S,Spatz J,Faleni R,Merzbacher B,Gales A,Moizeszowicz J

更新日期：1976-06-15 00:00:00

abstract：:The use of bioelectrical impedance (BI) analysis as a non-invasive approach for individualizing gentamicin therapy in newborn infants has been investigated in a two phase study. In Phase I, 1/impedance and length were identified as statistically significant predictors of the distribution volume of gentamicin (Adj R2 =...

journal_title：European journal of clinical pharmacology

authors： Sidhu JS,Charles BG,Triggs EJ,Tudehope DI,Gray PH,Steer PA

更新日期：1993-01-01 00:00:00

abstract：:In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in ...

journal_title：European journal of clinical pharmacology

authors： Lemmer B,Scheidel B,Blume H,Becker HJ

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast induced renal vasoconstriction is believed to play a pivotal role in the CMN mechanism. The aim of this pilot study was to examine the safety and efficacy of two d...

journal_title：European journal of clinical pharmacology

authors： Spargias K,Adreanides E,Giamouzis G,Karagiannis S,Gouziouta A,Manginas A,Voudris V,Pavlides G,Cokkinos DV

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients. DESIGN:Matched case-control study. SETTING:Large regional hospital in a mid-sized German city. SUBJECTS:Four hundred eighty-one inpatients aged ≥ 65 years who fell during hospitalization ("cases") an...

journal_title：European journal of clinical pharmacology

authors： Wedmann F,Himmel W,Nau R

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

journal_title：European journal of clinical pharmacology

authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

更新日期：2020-09-01 00:00:00

abstract：:In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

journal_title：European journal of clinical pharmacology

authors： Chauhan BL,Kulkarni RD

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Spinal-cord injury (SCI) is a leading cause of neuropathic pain (NP). Current pharmaceutical treatments for NP in SCI patients are not effective. Two promising options are gabapentin (GP) and pregabalin (PB). Their predominant mechanism of action is believed to be the inhibition of calcium currents, leading ...

journal_title：European journal of clinical pharmacology

authors： Tzellos TG,Papazisis G,Amaniti E,Kouvelas D

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：:In a double-blind, randomized study, the long-term effects of timolol and placebo on FEV1, PEFR, FVC, VC, respiratory rate and heart rate were compared in 32 patients surviving acute myocardial infarction, 17 on timolol and 15 on placebo. The patients were assessed before and after 1, 3 and 6 months of medication, and...

journal_title：European journal of clinical pharmacology

authors： Johansen S

更新日期：1985-01-01 00:00:00