A double blind comparative trial of nomifensin and desimipramine in depression. Relationship between treatment and phenylethylamine excretion.

abstract：PURPOSE:To investigate statin use in the elderly by age (≥ 80 vs. 65-79 years) in relation to established indications. METHODS:A population-based cohort, including data from four registers, encompassing inhabitants in Region Västra Götaland, Sweden, was used. Statin users were defined as those filling statin prescript...

journal_title：European journal of clinical pharmacology

authors： Sundvall H,Fastbom J,Wallerstedt SM,Vitols S

更新日期：2019-07-01 00:00:00

abstract：:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

更新日期：1987-01-01 00:00:00

abstract：:We have studied the kinetics of a single oral dose of mefloquine (750 mg) in 12 Thai patients with falciparum malaria and have compared the results with those of a previous study in 12 healthy Thai volunteers. All the patients responded to treatment with a mean parasite clearance time of 66.6 h and a mean fever cleara...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Back DJ,Bunnag D,Breckenridge AM

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 ...

journal_title：European journal of clinical pharmacology

authors： Oliveira-Paula GH,Coeli-Lacchini FB,Ferezin LP,Ferreira GC,Pinheiro LC,Paula-Garcia WN,Garcia LV,Tanus-Santos JE,Lacchini R

更新日期：2021-01-07 00:00:00

abstract：:A survey among hospital staff physicians was conducted in order to evaluate their attitudes towards systemic antimicrobial agents. Direct questions about the value of different agents and choice within pairs of antimicrobial drugs, stating the reasons for the preference, were included in the questionnaire used. Gentam...

journal_title：European journal of clinical pharmacology

authors： Gómez J,Erill S

更新日期：1979-03-26 00:00:00

abstract：:Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...

journal_title：European journal of clinical pharmacology

authors： Lameire N,Gordts J

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:To study the effect of renal impairment on the pharmacokinetics of sertindole. METHODS:A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creati...

journal_title：European journal of clinical pharmacology

authors： Wong SL,Menacherry S,Mulford D,Schmitz PJ,Locke C,Granneman GR

更新日期：1997-01-01 00:00:00

abstract：:The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins. Given orally for 5 days, torasemide was clinically very effective and well tolerated. On a weight basis, the diure...

journal_title：European journal of clinical pharmacology

authors： Broekhuysen J,Deger F,Douchamps J,Ducarne H,Herchuelz A

更新日期：1986-01-01 00:00:00

abstract：:The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...

journal_title：European journal of clinical pharmacology

authors： Pagano G,Lombardi A,Ferraris GM,Imbimbo B,Cavallo Perin P

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVES:The study was conducted to investigate whether oral co-administration with citrus juices significantly affects the pharmacokinetics and/or pharmacodynamics of pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy male subjects. Grapefruit juice and orange juice, which were both commercially a...

journal_title：European journal of clinical pharmacology

authors： Hashimoto K,Shirafuji T,Sekino H,Matsuoka O,Sekino H,Onnagawa O,Okamoto T,Kudo S,Azuma J

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with enta...

journal_title：European journal of clinical pharmacology

authors： Rocha JF,Falcão A,Santos A,Pinto R,Lopes N,Nunes T,Wright LC,Vaz-da-Silva M,Soares-da-Silva P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine the changes in consumption of psychotropic drugs by children aged less than 18 years during the years 1995 to 2001 in the Netherlands. METHODS:The year prevalence of antipsychotics, benzodiazepines, antidepressants and psychostimulants for boys and girls under 18 years w...

journal_title：European journal of clinical pharmacology

authors： Hugtenburg JG,Heerdink ER,Egberts AC

更新日期：2004-07-01 00:00:00

abstract：:A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC...

journal_title：European journal of clinical pharmacology

authors： Benkö S,Grézal G,Nagy E,Klebovich I

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predominates in rats, leads to h...

journal_title：European journal of clinical pharmacology

authors： Hadidi H,Irshaid Y,Vågbø CB,Brunsvik A,Cholerton S,Zahlsen K,Idle JR

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. METHODS:Human livers (n = 67) were genotyped for CYP2A6 alleles and assessed for nicotine metabolism and CYP2A6 expression (mRNA and protein). In addition, a subset...

journal_title：European journal of clinical pharmacology

authors： Al Koudsi N,Hoffmann EB,Assadzadeh A,Tyndale RF

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the cent...

journal_title：European journal of clinical pharmacology

authors： Drago A,Alboni S,Brunello N,De Ronchi D,Serretti A

更新日期：2010-01-01 00:00:00

abstract：:In this paper pharmaceutical and biopharmaceutical aspects on the development of long-acting nitrate delivery systems are reviewed. Basic considerations and requirements are also discussed. Recent product development activities are presented, with an emphasis on nitroglycerin in transdermal form and oral isosorbide-5-...

journal_title：European journal of clinical pharmacology

authors： Jonsson UE

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:The concentration of flecainide in hair was measured to determine its value as an index of individual drug-taking history. METHODS:Hair samples obtained from 15 patients treated with flecainide for more than 1 month were cut into 1-cm-long portions successively from its scalp end. The concentration of flecai...

journal_title：European journal of clinical pharmacology

authors： Takiguchi Y,Ishihara R,Torii M,Kato R,Kamihara S,Uematsu T

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To investigate the impact of valproic acid (VPA) and genetic polymorphism of the major metabolizing enzyme (UGT1A4, UGT2B7) of lamotrigine (LTG) and VPA on LTG concentration in Chinese epileptic children. METHODS:Three single nucleotide polymorphisms (UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2) were analyzed by p...

journal_title：European journal of clinical pharmacology

authors： Liu L,Zhao L,Wang Q,Qiu F,Wu X,Ma Y

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

journal_title：European journal of clinical pharmacology

authors： Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands. METHODS:In the Netherlands, health professionals and patients can report suspected ADRs to the Pharmacovigilance Centre Lareb. ...

journal_title：European journal of clinical pharmacology

authors： de Vries TW,de Langen-Wouterse JJ,van Puijenbroek E,Duiverman EJ,de Jong-Van den Berg LT

更新日期：2006-05-01 00:00:00

abstract：:7-3H-phenylephrine was given to 15 volunteers by a short-infusion n = 4) or p.o. (10 volunteers, 1 patient with porto-caval anastomosis). Analysis of serum for free 3H-phenylephrine and fractionation of urinary radioactivity was performed by ion-exchange and thin-layer chromatography. As almost the same 3H-activity wa...

journal_title：European journal of clinical pharmacology

authors： Hengstmann JH,Goronzy J

更新日期：1982-01-01 00:00:00

abstract：:Exposure to reserpine was compared in 181 women interviewed prior to biopsy and found to have breast cancer and 307 women found to have a benign disorder of the breast. The age-adjusted relative risk of breast cancer in those who had taken reserpine was 0.6 (95% confidence limits: 0.4 and 1.1). When the 181 breast can...

journal_title：European journal of clinical pharmacology

authors： Kewitz H,Jesdinsky HJ,Schröter PM,Lindtner E

更新日期：1977-01-03 00:00:00

abstract：:Migraine is the most common cause of vascular headache and a highly prevalent illness. In the last 20 years, the discovery of new agents has increased clinical research on migraine. In most of clinical trials that have been conducted, the efficacy was established using a placebo as a control treatment. The objective o...

journal_title：European journal of clinical pharmacology

authors： Macedo A,Farré M,Baños JE

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：:The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled n...

journal_title：European journal of clinical pharmacology

authors： Guerret M,Cheymol G,Hubert M,Julien-Larose C,Lavene D

更新日期：1989-01-01 00:00:00

abstract：:A new device for IV admixtures has been developed in Israel, the Vialink minibag. It consists of a partly filled minibag, attached by rubber tubing to a sterile receptable into which various types of vials containing drugs can be firmly inserted. Time and motion studies were conducted to determine the time and cost as...

journal_title：European journal of clinical pharmacology

authors： Lustig A

更新日期：1994-01-01 00:00:00

abstract：:The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgra...

journal_title：European journal of clinical pharmacology

authors： Moorthi K,Wiederholt K

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To illustrate the interface of pharmacogenetics and therapeutic drug monitoring and to estimate target blood level for imatinib in the treatment of chronic myelogenous leukemia METHODS:A literature review to provide the evidence and necessary data to support the case for the interface, and quantitative analysi...

journal_title：European journal of clinical pharmacology

authors： Li-Wan-Po A,Farndon P,Craddock C,Griffiths M

更新日期：2010-04-01 00:00:00