Abstract:
:The effect of nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes. Forty-three patients (23 in the nomifensin group and 20 in the desimipramine group) were studied for 6 weeks. Clinical follow-up was done with the Wittenborn scale (WPRS), Hamilton's rating scale for depression (HRS), Zung's scale (SDS), and the PEN inventory. The average daily dose was nomifensin 84 mg and desimipramine 76 mg. Changes in HRS, WPRS and SDS showed statistically significant improvement with both treatments. A moderate anxiolytic effect was found in the nomifensin group, whereas medication had to be discontinued in two desimipramine-treated patients because of its drive-enhancing effect. Urinary phenylethylamine excretion rose in 2 out of 8 patients after 5 weeks of treatment with nomifensin.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Acébal E,Subirá S,Spatz J,Faleni R,Merzbacher B,Gales A,Moizeszowicz Jdoi
10.1007/BF00609468subject
Has Abstractpub_date
1976-06-15 00:00:00pages
109-13issue
2eissn
0031-6970issn
1432-1041journal_volume
10pub_type
临床试验,杂志文章abstract:PURPOSE:To investigate statin use in the elderly by age (≥ 80 vs. 65-79 years) in relation to established indications. METHODS:A population-based cohort, including data from four registers, encompassing inhabitants in Region Västra Götaland, Sweden, was used. Statin users were defined as those filling statin prescript...
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journal_title:European journal of clinical pharmacology
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