Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans.

abstract：OBJECTIVE:The aim of the present study was to develop a real-time reverse-transcription polymerase chain reaction (RT-PCR) methodology for the quantification of thiopurine methyltransferase (TPMT) gene expression in whole blood and compare it with the TPMT enzyme activity measured in red blood cells. METHODS:TPMT gene...

journal_title：European journal of clinical pharmacology

authors： Lindqvist M,Almer S,Peterson C,Söderkvist P

更新日期：2003-07-01 00:00:00

abstract：:The purpose of the study was to examine long-term nicotine substitution and its variability during use of a nicotine patch. In two smoking cessation studies a 16-h nicotine patch, releasing 15 mg nicotine, was applied daily for 16 h over 12 weeks, to 167 smokers. Salivary cotinine was highly correlated with plasma cot...

journal_title：European journal of clinical pharmacology

authors： Nørregaard J,Tønnesen P,Simonsen K,Säwe U

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine the changes in consumption of psychotropic drugs by children aged less than 18 years during the years 1995 to 2001 in the Netherlands. METHODS:The year prevalence of antipsychotics, benzodiazepines, antidepressants and psychostimulants for boys and girls under 18 years w...

journal_title：European journal of clinical pharmacology

authors： Hugtenburg JG,Heerdink ER,Egberts AC

更新日期：2004-07-01 00:00:00

abstract：:Seventeen normotensive, premenopausal women were treated with the 5-hydroxytryptamine-reuptake inhibitor dexfenfluramine 30 mg per day, for 4 days in a randomised double-blind, cross-over, placebo controlled trial. Energy intake was held constant during the study as the aim was to study the endocrine and metabolic eff...

journal_title：European journal of clinical pharmacology

authors： Andersson B,Zimmermann ME,Hedner T,Björntorp P

更新日期：1991-01-01 00:00:00

abstract：:The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial. Enprofylline 4 mg/kg and theophylline 8 mg/kg produced mean maximum plasma levels of 4...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Søndergaard I,Weeke B

更新日期：1984-01-01 00:00:00

abstract：:Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfarin doses were adjusted to maintain the prothrombin time between 25-30% of control and its kinetics were compar...

journal_title：European journal of clinical pharmacology

authors： Almog S,Shafran N,Halkin H,Weiss P,Farfel Z,Martinowitz U,Bank H

更新日期：1985-01-01 00:00:00

abstract：:Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

journal_title：European journal of clinical pharmacology

authors： Kakavas S,Demestiha T,Vasileiou P,Xanthos T

更新日期：2011-01-01 00:00:00

abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

journal_title：European journal of clinical pharmacology

authors： Steinijans VW,Diletti E

更新日期：1985-01-01 00:00:00

abstract：:The dose-response relationship of the new bronchodilator Clenbuterol (NAB 365, Boehringer Ingelheim) was tested in 12 patients with chronic obstructive lung disease. Clenbuterol is a beta-2-sympathicomimetic, from a series of substituted phenylethanolamines, and it is characterised by good absorption and prolonged act...

journal_title：European journal of clinical pharmacology

authors： Tschan M,Perruchoud A,Herzog H

更新日期：1979-04-17 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

journal_title：European journal of clinical pharmacology

authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

更新日期：2020-09-01 00:00:00

abstract：:The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

journal_title：European journal of clinical pharmacology

authors： Coller JK,Christrup LL,Somogyi AA

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Higher drug concentrations in complex clinical scenarios in which multiple factors such as drug-drug interactions (DDIs) and comorbidities are simultaneously present are not necessarily rationalized in prospective clinical studies. Physiologically based pharmacokinetic (PBPK) modeling and simulation of the anti...

journal_title：European journal of clinical pharmacology

authors： Doki K,Kuga K,Aonuma K,Ieda M,Homma M

更新日期：2020-06-01 00:00:00

abstract：:Exposure to reserpine was compared in 181 women interviewed prior to biopsy and found to have breast cancer and 307 women found to have a benign disorder of the breast. The age-adjusted relative risk of breast cancer in those who had taken reserpine was 0.6 (95% confidence limits: 0.4 and 1.1). When the 181 breast can...

journal_title：European journal of clinical pharmacology

authors： Kewitz H,Jesdinsky HJ,Schröter PM,Lindtner E

更新日期：1977-01-03 00:00:00

abstract：:We have studied the transfer of the analgesic ketorolac tromethamine into breast milk in ten women aged between 22 and 35 years. Ketorolac administration was started between 2 and 6 days after delivery. The breast milk was not fed to the infant because of maternal antibiotic use (6 patients) or because of jaundice of ...

journal_title：European journal of clinical pharmacology

authors： Wischnik A,Manth SM,Lloyd J,Bullingham R,Thompson JS

更新日期：1989-01-01 00:00:00

abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

journal_title：European journal of clinical pharmacology

authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Serious adverse effects have been observed with some non-sedative H1-antihistamines (terfenadine and astemizole) when they were associated with drugs known to inhibit their metabolism. However, this is not a class effect, and this interaction should be considered on a case-by-case basis. The aim of this stud...

journal_title：European journal of clinical pharmacology

authors： Peytavin G,Gautran C,Otoul C,Cremieux AC,Moulaert B,Delatour F,Melac M,Strolin-Benedetti M,Farinotti R

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. METHODS:We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophyllin...

journal_title：European journal of clinical pharmacology

authors： Tsantes AE,Tassiopoulos ST,Papadhimitriou SI,Bonovas S,Poulakis N,Vlachou A,Filioussi K,Loukopoulos D

更新日期：2003-09-01 00:00:00

abstract：:The frequency distribution of the 8-h urinary ratio of log metoprolol/alpha-hydroxymetoprolol was assessed in 65 healthy, unrelated Jordanian volunteers. There was no apparent bimodality in the frequency distribution of this ratio among the subjects studied. The frequency of the poor metabolizer phenotype of metoprolo...

journal_title：European journal of clinical pharmacology

authors： al-Hadidi HF,Irshaid YM,Rawashdeh NM

更新日期：1994-01-01 00:00:00

abstract：:The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

journal_title：European journal of clinical pharmacology

authors： Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. METHODS:Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer; initially alone and 9 d...

journal_title：European journal of clinical pharmacology

authors： Bayés MC,Barbanoj MJ,Vallès J,Torrent J,Obach R,Jané F

更新日期：1996-01-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and ...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakashima M,Fujii M,Hamano K,Yasutomi M,Kodaira S,Kato T,Kotake K,Oka H,Masuike T

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：:(1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltrations. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylat...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Boobis SW,Moore MR,Goldberg A,Brodie MJ,Summer DJ

更新日期：1978-06-19 00:00:00

abstract：:Ten healthy subjects took single oral doses of placebo, 8.8 +/- 1.8 mg motapizone, 40 +/- 13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5 +/- 1.1 mg prazosin in random order, and, as the last preparation 500 mg acetylsalicylic acid. Thrombocyte aggregation induced "ex-vivo" with collagen, ADP and adrena...

journal_title：European journal of clinical pharmacology

authors： Schulz V,Fischer W,Hanselle U,Huhmann W,Zietsch V

更新日期：1986-01-01 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：:In order to assess whether dinnertime administration of a once daily dose of famotidine is more advantageous than a bedtime dose in suppressing evening and nocturnal gastric acidity, we gave nine patients with a past history of duodenal ulcer in double-blind, randomized fashion either (1) placebo at 6 p.m. and 10 p.m....

journal_title：European journal of clinical pharmacology

authors： Savarino V,Mela GS,Scalabrini P,Fera G,Zentilin P,Sumberaz A,Celle G

更新日期：1988-01-01 00:00:00

abstract：AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmaco...

journal_title：European journal of clinical pharmacology

authors： Choi DH,Shin WG,Choi JS

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

journal_title：European journal of clinical pharmacology

authors： Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

更新日期：2020-11-11 00:00:00