当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure.

Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure.

Abstract：

INTRODUCTION:Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge, the pharmacokinetics of epidural hydromorphone has not been evaluated in parturients. MATERIALS AND METHODS:In this pilot study, seven healthy parturients were given a single epidural dose of hydromorphone for labour pain. One parturient received 1.5 mg, two 0.75 mg and four 0.5 mg of hydromorphone hydrochloride. Dose was decreased due to nausea and pruritus. Hydromorphone's effect, adverse effects and plasma concentrations were evaluated. Neonatal drug exposure was evaluated by umbilical vein and artery opioid concentration at birth. Neonatal outcomes were assessed using Apgar and the Neurologic Adaptive Capacity Score (NACS). RESULTS:All patients received additional levobupivacaine doses on parturients' requests. The first dose was requested at a median of 163 min (range 19-303 min) after hydromorphone administration. A total of 12 opioid related expected adverse events were reported by seven parturients. All newborn outcomes were uneventful. Hydromorphone's distribution and elimination after single epidural dose seem similar to that reported for non-pregnant subjects after intravenous hydromorphone administration, but further research is required to confirm this observation. CONCLUSIONS:The optimal dose of hydromorphone in labour pain warrants further evaluation.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Puhto T,Kokki M,Hakomäki H,Spalding M,Gunnar T,Alahuhta S,Vakkala M

doi

10.1007/s00228-020-02880-6

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

969-977

issue

7

eissn

0031-6970

issn

1432-1041

pii

10.1007/s00228-020-02880-6

journal_volume

76

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Beta-blockade antagonism of tyramine-induced rise in blood pressure.

    abstract：:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00540953

    authors： Colombo F,Sega R,Mailland F,Rigo R,Palvarini L,Libretti A

    更新日期：1988-01-01 00:00:00

  • Allele and genotype frequencies of polymorphic DCP1, CETP, ADRB2, and HTR2A in the Egyptian population.

    abstract：OBJECTIVE:The goal of this study was to determine the frequencies of important allelic variants of two drug targets, dipeptidyl carboxypeptidase ( DCP1) and cholesteryl ester transfer protein ( CETP), and two other drug receptors, beta-2 adrenergic receptor ( ADRB2) and 5-hydroxy tryptamine 2A receptor ( HTR2A), in the...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-002-0423-z

    authors： Hamdy SI,Hiratsuka M,Narahara K,El-Enany M,Moursi N,Ahmed MS,Mizugaki M

    更新日期：2002-04-01 00:00:00

  • Effects of diltiazem and metoprolol on blood pressure, adverse symptoms and general well-being. The Swedish Diltiazem-Metoprolol Multi-Centre Study Group.

    abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/BF00315222

    authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

    更新日期：1991-01-01 00:00:00

  • The excretion of ketorolac tromethamine into breast milk after multiple oral dosing.

    abstract：:We have studied the transfer of the analgesic ketorolac tromethamine into breast milk in ten women aged between 22 and 35 years. Ketorolac administration was started between 2 and 6 days after delivery. The breast milk was not fed to the infant because of maternal antibiotic use (6 patients) or because of jaundice of ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558080

    authors： Wischnik A,Manth SM,Lloyd J,Bullingham R,Thompson JS

    更新日期：1989-01-01 00:00:00

  • Measuring medication adherence in older community-dwelling patients with multimorbidity.

    abstract：PURPOSE:Older people with several chronic conditions require multiple drugs from different classes to be adequately treated. This study aims to: (i) measure medication adherence across multiple conditions and therapeutic drug groups in older community-dwelling patients, and (ii) examine the effect of multimorbidity on ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00228-017-2388-y

    authors： Kim S,Bennett K,Wallace E,Fahey T,Cahir C

    更新日期：2018-03-01 00:00:00

  • Hospital electronic prescribing system implementation impact on discharge information communication and prescribing errors: a before and after study.

    abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-017-2274-7

    authors： Mills PR,Weidmann AE,Stewart D

    更新日期：2017-10-01 00:00:00

  • Drug prescription in diabetic patients in Stockholm in 1992 and 1995--change over time.

    abstract：OBJECTIVE:To describe and compare the distribution of prescribed drugs in diabetic patients between 1992 and 1995. METHODS:Two cross-sectional surveys of a random selection of medical records of diabetic patients, from three community health centres (CHCs) in the Stockholm metropolitan area, were carried out. The age ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050285

    authors： Wändell PE,Brorsson B,Aberg H

    更新日期：1997-01-01 00:00:00

  • Cleansing properties of stabilized trypsin and streptokinase-streptodornase in necrotic leg ulcers.

    abstract：:The cleansing effects on pus and debris of streptokinase-streptodornase and of stabilized crystalline trypsin were compared in 40 patients (12 males, 28 females) with necrotic varicose or arteriosclerotic leg ulcers. Both preparations produced significant partial or total cleansing of the ulcers of necrotic material, ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00542211

    authors： Hellgren L

    更新日期：1983-01-01 00:00:00

  • Identification of Dutch children diagnosed with atopic diseases using prescription data: a validation study.

    abstract：PURPOSE:The aim of this study is to validate medication proxies for the identification of children diagnosed with atopic disorders that can be applied in various types of epidemiological research. METHODS:Records of 7439 children, aged between 0 and 10 years, in the period 2001 until 2010, were retrieved from the Regi...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1940-x

    authors： Mulder B,Groenhof F,Kocabas LI,Bos HJ,De Vries TW,Hak E,Schuiling-Veninga C

    更新日期：2016-01-01 00:00:00

  • Differential inhibition of hepatic and duodenal sulfation of (-)-salbutamol and minoxidil by mefenamic acid.

    abstract：OBJECTIVE:The aim of this investigation was to determine whether mefenamic acid and salicylic acid inhibit the sulfation of (-)-salbutamol and minoxidil in the human liver and duodenum, and if so, to ascertain whether the 50% inhibitory concentration (IC50) estimates are different in the two tissues. METHODS:Sulfotran...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280000168

    authors： Vietri M,Pietrabissa A,Spisni R,Mosca F,Pacifici GM

    更新日期：2000-09-01 00:00:00

  • Haemodynamic effects and kinetics of concomitant intravenous disopyramide and atenolol in patients with ischaemic heart disease.

    abstract：:The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00614295

    authors： Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

    更新日期：1986-01-01 00:00:00

  • Detection and incidence of drug-induced agranulocytosis in hospital: a prospective analysis from laboratory signals.

    abstract：AIMS:Our objectives were to assess the detection and incidence of drug-induced agranulocytosis in two university hospitals using hematology laboratory data. METHODS:A prospective study was undertaken at Toulouse University Hospital (France) and Navarra University Hospital (Spain) for 1 year (from 1 May 2004 to 30 Apri...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0242-8

    authors： Tavassoli N,Duchayne E,Sadaba B,Desboeuf K,Sommet A,Lapeyre-Mestre M,Muoz MJ,Sie P,Honorato J,Montastruc JL,Bagheri H

    更新日期：2007-03-01 00:00:00

  • Displacement of lidocaine from serum alpha 1-acid glycoprotein binding sites by basic drugs.

    abstract：:Since little is known of the number and types of binding sites on alpha 1-acid glycoprotein (AAG) and because drug-drug protein binding interactions often fail to fit a simple model, a study of the effect of 9 known AAG binding drugs on lidocaine free fraction (LFF) was performed. Serum was obtained from 10 healthy ma...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF01037957

    authors： Goolkasian DL,Slaughter RL,Edwards DJ,Lalka D

    更新日期：1983-01-01 00:00:00

  • Dextromethorphan metabolic phenotyping in an Iranian population.

    abstract：OBJECTIVE:CYP2D6 polymorphism of drug metabolism represents an important source of interindividual and interethnic variation in drug response. Since this polymorphism has not been studied in an Iranian population, the present study was undertaken. METHODS:Two hundred healthy unrelated Iranian subjects participated in ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-004-0859-4

    authors： Afshar M,Rouini M,Ala S

    更新日期：2005-02-01 00:00:00

  • Comparison of nicardipine and propranolol in the treatment of mild and moderate hypertension.

    abstract：:In a double-blind controlled trial 22 patients with mild or moderate essential hypertension were treated with nicardipine 30 mg t.d.s. and 19 patients with propranolol 80 mg t.d.s. as monotherapy for 24 weeks. Blood pressure in both groups at the end of trial was equally and significantly reduced; systolic pressure 22...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00544554

    authors： Naukkarinen VA,Karppinen K,Sarna S

    更新日期：1987-01-01 00:00:00

  • Increased oral clearance of metoprolol in pregnancy.

    abstract：:The disposition of oral metoprolol was studied in 5 women during the last trimester of pregnancy and 3 to 5 months after delivery. After a single oral dose of 100 mg the individual peak plasma concentration in the pregnant state was only 20-40% of that after pregnancy. The plasma half-lives of metoprolol were about th...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00613820

    authors： Högstedt S,Lindberg B,Rane A

    更新日期：1983-01-01 00:00:00

  • Protein binding of drugs in plasma, interstitial fluid and tissues: effect on pharmacokinetics.

    abstract：:Drug binding in the interstitial fluid as well as in the plasma must be taken into account when considering the pharmacokinetics of drugs which are highly bound to plasma proteins and have a relatively small apparent volume of distribution (V). The half-life and apparent volume of distribution of such a drug can be af...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00609592

    authors： Faed EM

    更新日期：1981-01-01 00:00:00

  • Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study.

    abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02913-0

    authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

    更新日期：2020-09-01 00:00:00

  • Medication and medical diagnosis as risk factors for falls in older hospitalized patients.

    abstract：OBJECTIVE:To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients. DESIGN:Matched case-control study. SETTING:Large regional hospital in a mid-sized German city. SUBJECTS:Four hundred eighty-one inpatients aged ≥ 65 years who fell during hospitalization ("cases") an...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02668-3

    authors： Wedmann F,Himmel W,Nau R

    更新日期：2019-08-01 00:00:00

  • Comparison of pharmacokinetic profile of levodopa throughout the day between levodopa/carbidopa/entacapone and levodopa/carbidopa when administered four or five times daily.

    abstract：OBJECTIVES:To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS:Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-009-0622-y

    authors： Kuoppamäki M,Korpela K,Marttila R,Kaasinen V,Hartikainen P,Lyytinen J,Kaakkola S,Hänninen J,Löyttyniemi E,Kailajärvi M,Ruokoniemi P,Ellmén J

    更新日期：2009-05-01 00:00:00

  • Prizidilol (SK & F 92657), a new vasodilator with beta-blocking properties in the treatment of essential hypertension.

    abstract：:The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00605990

    authors： Lüscher T,Havelka J,Greminger P,Tuma J,Täuber M,Siegenthaler W,Vetter W

    更新日期：1982-01-01 00:00:00

  • Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants.

    abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-013-1471-2

    authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

    更新日期：2013-06-01 00:00:00

  • CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics.

    abstract：OBJECTIVE:The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear mixed-effects model (NONMEM) analysis in Japanese adults with epilepsy. METHODS:A total of 144 serum PB concentrations were obtained from 74 subjects treated wi...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280050703

    authors： Mamiya K,Hadama A,Yukawa E,Ieiri I,Otsubo K,Ninomiya H,Tashiro N,Higuchi S

    更新日期：2000-02-01 00:00:00

  • Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiency.

    abstract：PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-009-0643-6

    authors： Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

    更新日期：2009-08-01 00:00:00

  • Grapefruit juice has no effect on quinine pharmacokinetics.

    abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050646

    authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

    更新日期：1999-07-01 00:00:00

  • Generalization of distribution--free confidence intervals for bioavailability ratios.

    abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635713

    authors： Steinijans VW,Diletti E

    更新日期：1985-01-01 00:00:00

  • Deflazacort in the treatment of haematologic disorders.

    abstract：:Glucocorticoids (GCs) exert different activities that are useful for the treatment of several haematologic disorders. The synergistic effect with cytotoxic drugs is important for the therapy of lymphoproliferative diseases. The inhibition of macrophages prevents acute haemolysis and platelets destruction in autoimmune...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF01844200

    authors： Gobbi M,Scudeletti M

    更新日期：1993-01-01 00:00:00

  • Interaction between valproate formulation and phenytoin concentrations.

    abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00202174

    authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

    更新日期：1995-01-01 00:00:00

  • Polypharmacy and potentially inappropriate medications: a cross-sectional analysis among 451 nursing homes in France.

    abstract：PURPOSE:The quality of drug therapy is an important issue for nursing homes. This study aimed to assess the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in a large sample of nursing home residents by using the data recorded during the preparation of pill dispensers. METHODS:This is a cro...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2193-z

    authors： Herr M,Grondin H,Sanchez S,Armaingaud D,Blochet C,Vial A,Denormandie P,Ankri J

    更新日期：2017-05-01 00:00:00

  • Non-steroidal anti-inflammatory drugs: use and co-treatment with potentially interacting medications in the elderly.

    abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-010-0825-2

    authors： Vandraas KF,Spigset O,Mahic M,Slørdal L

    更新日期：2010-08-01 00:00:00