Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiency.

abstract：:Our goal was to develop a pharmacokinetic-pharmacodynamic model that describes the fate of atracurium and its metabolite laudanosine as well as the time course of the neuromuscular block. The model was based on the consideration of mass balance of atracurium and was constructed by postulating an effect compartment lin...

journal_title：European journal of clinical pharmacology

authors： Nigrovic V,Gaspari J,Banoub M

更新日期：1996-01-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

journal_title：European journal of clinical pharmacology

authors： Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinetics of lovastatin. METHODS:In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment wi...

journal_title：European journal of clinical pharmacology

authors： Bucher M,Mair G,Kees F

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Reimbursement databases are potentially invaluable tools to develop and conduct pharmacoepidemiological studies on drug use. However, two types of factors that may influence the performance of a database can be distinguished: firstly, factors related to the constitution of the database, and secondly, facto...

journal_title：European journal of clinical pharmacology

authors： Latry P,Molimard M,Bégaud B,Martin-Latry K

更新日期：2010-07-01 00:00:00

abstract：:A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5 alpha-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Depré M,Schwartz JI,Tjandramaga TB,Winchell GA,De Lepeleire I,Ng J,De Schepper PJ

更新日期：1994-01-01 00:00:00

abstract：:The sulphation of (+) and (-) terbutaline was investigated in specimens of human intestinal mucosa isolated from the duodenum, ileum, ascending colon and sigmoid colon and in specimens of liver and lung. The lung specimens came from 8 current smokers and 11 ex-smokers, the latter having stopped at least 3 months befor...

journal_title：European journal of clinical pharmacology

authors： Pacifici GM,Eligi M,Giuliani L

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The concentration of flecainide in hair was measured to determine its value as an index of individual drug-taking history. METHODS:Hair samples obtained from 15 patients treated with flecainide for more than 1 month were cut into 1-cm-long portions successively from its scalp end. The concentration of flecai...

journal_title：European journal of clinical pharmacology

authors： Takiguchi Y,Ishihara R,Torii M,Kato R,Kamihara S,Uematsu T

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to examine the effects of genetic and clinical factors on the maintenance dose of tacrolimus in patients following renal transplantation and to develop a tacrolimus-dosing model that could be combined with associated factors. PATIENTS AND METHODS:This study included 142 renal tra...

journal_title：European journal of clinical pharmacology

authors： Li L,Li CJ,Zheng L,Zhang YJ,Jiang HX,Si-Tu B,Li ZH

更新日期：2011-08-01 00:00:00

abstract：:The antihypertensive effects of urapidil and clonidine have been studied in a double-blind cross-over trial in 11 hypertensive outpatients with mild to moderate hypertension, at rest and during isometric exercise. Urapidil 30 mg b.i.d. significantly decreased the standing diastolic blood pressure (p less than 0.05) an...

journal_title：European journal of clinical pharmacology

authors： Kanniainen E,Heikkilä O,Jääskeläinen T,Lilja M,Jounela AJ

更新日期：1985-01-01 00:00:00

abstract：:The effects in vitro and in vivo of triiodothyronine on certain functions of human lymphocytes and polymorphonuclear granulocytes have been investigated. Triiodothyronine was able to enhance the phagocytic capacity and chemiluminescent activity of polymorphonuclear granulocytes. PHA-P-induced 3H-thymidine incorporatio...

journal_title：European journal of clinical pharmacology

authors： Balázs C,Leövey A,Szabó M,Bakó G

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:In order to document the stereoselective distribution in joints of a chiral nonsteroidal anti-inflammatory drug, the relative affinities of the enantiomers of tiaprofenic acid in synovium and for cartilage were compared. METHODS:The distribution of tiaprofenic acid in synovium and in cartilage was studied 25...

journal_title：European journal of clinical pharmacology

authors： Lapicque F,Mainard D,Gillet P,Payan E,Bannwarth B,Netter P

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

journal_title：European journal of clinical pharmacology

authors： Mills PR,Weidmann AE,Stewart D

更新日期：2017-10-01 00:00:00

abstract：:Clorazepate 20 mg was given i.m. to 49 mothers during the first stage of labour. The elimination of the drug was studied in 27 newborns produced by these mothers. The same dose was given to 13 women who underwent amniocentesis and to 7 women who were breast-feeding. "Total nordiazepam", i.e. the sum of clorazepate and...

journal_title：European journal of clinical pharmacology

authors： Rey E,Giraux P,d'Athis P,Turquais JM,Chavinie J,Olive G

更新日期：1979-04-17 00:00:00

abstract：:The gastric inhibitory effects of CM57755, a new histamine H2 receptor antagonist, have been compared in ten healthy male volunteers with the actions of an equal dose of cimetidine and with placebo. The inhibitory effect of CM57755 was virtually identical with, and not significantly different from the effects of cimet...

journal_title：European journal of clinical pharmacology

authors： Wilson JA,Johnston D,Penston J,Wormsley KG

更新日期：1986-01-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS:The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (C...

journal_title：European journal of clinical pharmacology

authors： Pedersen RS,Damkier P,Christensen MM,Brosen K

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVE:In the present randomized, fourway crossover study we determined the effects of two oral doses each of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man. METHODS:Twelve healthy female volunteers received for 2 consecutive days, followed by a 5-day drug-free interval, one of the...

journal_title：European journal of clinical pharmacology

authors： Stichtenoth DO,Tsikas D,Gutzki FM,Frölich JC

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the dose-response relationship of increasing doses of oxymetazoline compared with placebo in normal subjects, and to determine the sensitivities of rhinomanometry, acoustic rhinometry and symptoms in discriminating between differing doses of oxymetazoline in normal subjects. METHODS:The study ha...

journal_title：European journal of clinical pharmacology

authors： Taverner D,Bickford L,Shakib S,Tonkin A

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:To assess the effect of an intervention on general practitioners' (GPs) knowledge about the diagnosis and treatment of asthma, including the prescribing of anti-asthmatic drugs, and asthmatic patients' knowledge about their disease. METHODS:The study took place in the south-west region of Stockholm County. I...

journal_title：European journal of clinical pharmacology

authors： Tomson Y,Hasselström J,Tomson G,Aberg H

更新日期：1997-01-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:We assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects. METHODS:Forty-one renal allograft recipients were studied. The tar...

journal_title：European journal of clinical pharmacology

authors： Satoh S,Saito M,Inoue T,Kagaya H,Miura M,Inoue K,Komatsuda A,Tsuchiya N,Suzuki T,Habuchi T

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Drug utilization studies have applied different methods to various data types to describe medication use, which hampers comparisons across populations. The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a unif...

journal_title：European journal of clinical pharmacology

authors： Abbing-Karahagopian V,Huerta C,Souverein PC,de Abajo F,Leufkens HG,Slattery J,Alvarez Y,Miret M,Gil M,Oliva B,Hesse U,Requena G,de Vries F,Rottenkolber M,Schmiedl S,Reynolds R,Schlienger RG,de Groot MC,Klungel OH,va

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Sequential and concomitant therapies are two innovative therapies for Helicobacter pylori (H. pylori) eradication. However, the comparative efficacy and safety of these treatments are controversial. Therefore, we aimed to conduct an updated systematic review and meta-analysis of studies that compared these t...

journal_title：European journal of clinical pharmacology

authors： Wang Y,Zhao R,Wang B,Zhao Q,Li Z,Zhu-Ge L,Yin W,Xie Y

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the effects of benazepril and amlodipine in monotherapy versus in combination with plasma t-PA and PAI-1 activity in hypertensive type-2 diabetic patients. METHODS:After an initial 6-week wash-out, single-blind placebo period, 38 patients, 17 men and 21 females, were rand...

journal_title：European journal of clinical pharmacology

authors： Fogari R,Preti P,Lazzari P,Corradi L,Zoppi A,Fogari E,Mugellini A

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVES:Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. METHODS:A single dose of diclofenac was administered orally to 12 healthy subjects in whom...

journal_title：European journal of clinical pharmacology

authors： Shimamoto J,Ieiri I,Urae A,Kimura M,Irie S,Kubota T,Chiba K,Ishizaki T,Otsubo K,Higuchi S

更新日期：2000-04-01 00:00:00

abstract：:The effect of the GABAergic drug sodium valproate (SV) on the exercise-induced release of growth hormone (GH) was investigated in 10 healthy males. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. SV 600 mg blunted the increase in GH induced by the exercise, suggesting GABA...

journal_title：European journal of clinical pharmacology

authors： Steardo L,Iovino M,Monteleone P,Agrusta M,Orio F

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive...

journal_title：European journal of clinical pharmacology

authors： Piguet V,Desmeules J,Dayer P

更新日期：1998-01-01 00:00:00