当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiency.

Pro-active provision of drug information as a technique to address overdosing in intensive-care patients with renal insufficiency.

Abstract：

PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a structured report containing recommendations as to whether and how to adjust dosage in the individual patient (intervention). Prevalence of overdosed drugs (primary outcome), extent of overdoses, and reasons for nonacceptance of recommendations (secondary outcomes) were assessed. RESULTS:Of 138 screened intensive-care patients, 68 (49%) had renal impairment, and 110 (14%) of the 805 prescribed drugs required consideration of renal function. A potential overdose was found in 53/110 drugs (48%) and this rate decreased to 26/110 (24%, P < 0.001) after the intervention. The average extent of overdose was reduced from 54% before to 31% after the intervention (P < 0.001). The main reasons expressed by the physicians for nonacceptance of recommendations were a large therapeutic index or minor overdoses of the involved drugs. CONCLUSIONS:In intensive-care patients, overdosing of drugs requiring adjustment based on renal function is still very common. Drug information counselling significantly decreased the prevalence and extent of overdose.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

doi

10.1007/s00228-009-0643-6

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

823-9

issue

8

eissn

0031-6970

issn

1432-1041

journal_volume

65

pub_type

杂志文章

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