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Chloramphenicol pharmacokinetics in Ethiopian children of differing nutritional status.

Abstract：

:The pharmacokinetics of i.v. chloramphenicol succinate and oral chloramphenicol palmitate were studied in Ethiopian children with different nutritional states. In children with kwashiorkor the plasma clearance of chloramphenicol was significantly lower than in children of normal weight (4.16 ml/min/kg versus 7.53 ml/min/kg). In consequence the mean half-life was prolonged (3.76 h versus 2.85 h) and this led to somewhat higher plasma levels in the kwashiorkor children. The influence of the pathophysiological changes offset one another so that plasma concentrations within the therapeutic range were obtained in children with kwashiorkor given recommended standard i.v. doses. The absorption of chloramphenicol after oral administration in severely malnourished children was erratic, which suggests that this route should be avoided in such patients.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Eriksson M,Paalzow L,Bolme P,Mariam TW

doi

10.1007/BF00607094

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

819-23

issue

6

eissn

0031-6970

issn

1432-1041

journal_volume

24

pub_type

杂志文章

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