Comparison of oral enprofylline and theophylline in asthmatic patients.

abstract：PURPOSE:The quality of drug therapy is an important issue for nursing homes. This study aimed to assess the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in a large sample of nursing home residents by using the data recorded during the preparation of pill dispensers. METHODS:This is a cro...

journal_title：European journal of clinical pharmacology

authors： Herr M,Grondin H,Sanchez S,Armaingaud D,Blochet C,Vial A,Denormandie P,Ankri J

更新日期：2017-05-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：:The duration and extent of cardiac beta-blockade and their relationship to propranolol pharmacokinetics were assessed in nine healthy volunteers. Each subject received 160 mg of regular propranolol (R), 160 mg of sustained-release propranolol (SR) and no drug (control), both as single doses and once daily for 7 days. ...

journal_title：European journal of clinical pharmacology

authors： Lalonde RL,Pieper JA,Straka RJ,Bottorff MB,Mirvis DM

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

journal_title：European journal of clinical pharmacology

authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

更新日期：1984-01-01 00:00:00

abstract：:The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62-79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg daily for 8 weeks. Periphe...

journal_title：European journal of clinical pharmacology

authors： Nagakawa Y,Akedo Y,Kaku S,Orimo H

更新日期：1990-01-01 00:00:00

abstract：:A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the met...

journal_title：European journal of clinical pharmacology

authors： Mårtensson J,Denneberg T,Kågedal B

更新日期：1986-01-01 00:00:00

abstract：:Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged ...

journal_title：European journal of clinical pharmacology

authors： Sjö O,Hvidberg EF,Naestoft J,Lund M

更新日期：1975-04-04 00:00:00

abstract：:In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. ...

journal_title：European journal of clinical pharmacology

authors： Lombardi C,Missale C,De Cotiis R,Spedini C,Pizzoccolo G,Memo M,Albertini A,Spano PF

更新日期：1988-01-01 00:00:00

abstract：:The Danish retail pharmacies' drug subsidy system is completely computerized. The data are person-identifiable, making it possible to chart the population's drug use from the perspective of individual users. We decided to explore the potential of this data source and to analyse heavy drug users specifically. The analy...

journal_title：European journal of clinical pharmacology

authors： Hallas J,Nissen A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:This exploratory study was aimed at elucidating the pharmacogenetics of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) and their implications on docetaxel pharmacokinetics and pharmacodynamics in local Chinese nasopharyngeal cancer patients. METHODS:A total of 59 single nucleotide polymorphisms (SNPs)...

journal_title：European journal of clinical pharmacology

authors： Chew SC,Lim J,Singh O,Chen X,Tan EH,Lee EJ,Chowbay B

更新日期：2014-02-01 00:00:00

abstract：:The pharmacokinetics, hypotensive effect and tolerability of a new vasodilator, tolmesoxide (T), have been studied in 6 uncontrolled hypertensive patients receiving atenolol and diuretic. After a 50 mg oral dose mean (+/- SD) peak plasma concentration of T was 1.13 +/- 0.29 micrograms/ml-1 and occurred 0.79 +/- 0.40 h...

journal_title：European journal of clinical pharmacology

authors： Silas JH,Phillips FC,Freestone S,Tucker GT,Ramsay LE

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To assess the pharmacokinetics, safety and tolerability of escalating oral doses of GW420867X, a non-nucleoside reverse transcriptase inhibitor, was investigated in healthy male volunteers in a randomized, double-blind placebo-controlled study. METHODS:Study subjects were divided into four groups of 12 subje...

journal_title：European journal of clinical pharmacology

authors： Moore KH,Cass LM,Dallow N,Hardman TC,Jones A,Boyce M,Prince WT

更新日期：2001-01-01 00:00:00

abstract：:Drug utilization was studied in children below 14 years of age in Tenerife, Canary Islands, who were seen as outpatients by 15 paediatricians and 10 general practitioners. Data on diagnosis, previous drug exposure and prescriptions were collected from a random sample of 1327 children. Nose and throat infections (40.1%...

journal_title：European journal of clinical pharmacology

authors： Sanz EJ,Boada JN

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...

journal_title：European journal of clinical pharmacology

authors： Suzuki T,Higa S,Sakoda S,Ueji M,Hayashi A,Takaba Y,Nakajima A

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Little is known about patient compliance with oral adjuvant chemotherapy. It is estimated to be poor especially in Japan, where it is still unusual for patients to be directly informed of their diagnosis of malignancy. 5-Fluorouracil (5-FU) was measured in hair samples to assess patient exposure to 5-FU, and ...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakashima M,Fujii M,Hamano K,Yasutomi M,Kodaira S,Kato T,Kotake K,Oka H,Masuike T

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

journal_title：European journal of clinical pharmacology

authors： Fairweather DB,Kerr JS,Hindmarch I

更新日期：1992-01-01 00:00:00

abstract：:The kinetics of mefloquine were studied in 12 healthy Thai male and 12 healthy Thai female volunteers. Mefloquine (MQ) was administered either alone (750 mg orally) or in combination (MSP) with sulphadoxine (1.5 g) and pyrimethamine (75 mg) to each of 6 male and 6 female subjects. Plasma concentrations of MQ were meas...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Bunnag D,Breckenridge AM,Back DJ

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:There are concerns regarding appropriate use of antibiotics in dentistry practice. Data on dental antibiotic prescribing patterns by dentists is relatively limited. This nationwide study aimed to examine dentists' antibiotic prescriptions in a diagnosis-based manner in Turkey. METHODS:This retrospective study ...

journal_title：European journal of clinical pharmacology

authors： Koyuncuoglu CZ,Aydin M,Kirmizi NI,Aydin V,Aksoy M,Isli F,Akici A

更新日期：2017-08-01 00:00:00

abstract：AIM:The aim of this study was to quantify the reasons and opinions of patients who reported adverse drug reactions (ADRs) in the Netherlands to a pharmacovigilance centre. METHOD:A web-based questionnaire was sent to 1370 patients who had previously reported an ADR to a pharmacovigilance centre. The data were analysed...

journal_title：European journal of clinical pharmacology

authors： van Hunsel F,van der Welle C,Passier A,van Puijenbroek E,van Grootheest K

更新日期：2010-11-01 00:00:00

abstract：:The pharmacokinetics of a single dose of netilmicin (NM) was studied in 6 healthy volunteers. Elimination of the drug was followed in serum and urine for 24 h and 72 h, respectively. NM concentrations were measured with a modified radioenzymatic assay. A three compartment open model was employed to calculate the pharm...

journal_title：European journal of clinical pharmacology

authors： Wenk M,Spring P,Vozeh S,Follath F

更新日期：1979-11-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：:The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers i...

journal_title：European journal of clinical pharmacology

authors： Kofahl B,Henke D,Hettenbach A,Mutschler E

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine the changes in consumption of psychotropic drugs by children aged less than 18 years during the years 1995 to 2001 in the Netherlands. METHODS:The year prevalence of antipsychotics, benzodiazepines, antidepressants and psychostimulants for boys and girls under 18 years w...

journal_title：European journal of clinical pharmacology

authors： Hugtenburg JG,Heerdink ER,Egberts AC

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual variation in the metabolic ratio (MR), i.e. quinine/3-hydroxyquinine. METHODS:Data from a previous study (A) was used for determination of the MR of quini...

journal_title：European journal of clinical pharmacology

authors： Mirghani RA,Ericsson O,Tybring G,Gustafsson LL,Bertilsson L

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:We sought to quantify the influence of the CYP3A inhibitor erythromycin on the pharmacokinetics of everolimus, a CYP3A substrate. METHODS:This was a two-period, single-sequence, crossover study in 16 healthy subjects. In period 1, subjects received the reference treatment of a single 2-mg dose of everolimus....

journal_title：European journal of clinical pharmacology

authors： Kovarik JM,Beyer D,Bizot MN,Jiang Q,Shenouda M,Schmouder RL

更新日期：2005-03-01 00:00:00

abstract：AIM:To describe and evaluate spontaneous reports of suspected adverse reactions (ARs) associated with herbal laxatives received by the Italian Medicines Agency and the Italian National Institute of Health between April 2002 and January 2011. METHODS:Spontaneous reports of suspected ARs were individually analyzed by a ...

journal_title：European journal of clinical pharmacology

authors： Vitalone A,Menniti-Ippolito F,Raschetti R,Renda F,Tartaglia L,Mazzanti G

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

journal_title：European journal of clinical pharmacology

authors： Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

更新日期：2018-12-01 00:00:00