Increased psychotropic drug consumption by children in the Netherlands during 1995-2001 is caused by increased use of methylphenidate by boys.

abstract：:The pharmacokinetics of ethanol in plasma and whole blood have been investigated and the results used to estimate the volume of total body water (TBW) by means of the dilution principle. Fifteen men (mean age 62 y) were given 0.6 g ethanol/kg body weight as an intravenous infusion over 1 h. The peak concentration of e...

journal_title：European journal of clinical pharmacology

authors： Jones AW,Hahn RG,Stalberg HP

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Psychosis is a common complication of the drug treatment of Parkinson's disease (PD). Treatment of this complication is difficult as most antipsychotic drugs worsen motor symptoms of PD. Only the atypical antipsychotic clozapine improves psychosis without worsening of parkinsonism. The aim of the present stud...

journal_title：European journal of clinical pharmacology

authors： van de Vijver DA,Roos RA,Jansen PA,Porsius AJ,de Boer A

更新日期：2002-05-01 00:00:00

abstract：:Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with SJW resulted in decreased plasma conce...

journal_title：European journal of clinical pharmacology

authors： Madabushi R,Frank B,Drewelow B,Derendorf H,Butterweck V

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Iatrogenesis is common in elderly patients. This phenomenon could be reduced by improving awareness of general practitioners (GPs). We studied GPs' prescribing behavior to elderly patients, to identify GP and patient characteristics related to cautious prescribing behaviors. METHODS:The observational study ...

journal_title：European journal of clinical pharmacology

authors： Fantino B,Voirin N,Laforest L,Fantino F,Chretin S,Van Ganse E

更新日期：2006-07-01 00:00:00

abstract：:1. The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive action of a single oral dose of 25 micrograms pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers, using a non-invasive method. 2. Compared with domperidon...

journal_title：European journal of clinical pharmacology

authors： al-Sereiti MR,Quik RF,Hedges A,Turner P

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Anaphylaxis is a potentially fatal systemic adverse drug reaction (ADR). It is an unpredictable and mostly dose-independent event that occurs suddenly following exposure to the causative drug. Our objective was to characterize a case series of anaphylactic reactions reported to the Portuguese Pharmacovigilance ...

journal_title：European journal of clinical pharmacology

authors： Ribeiro-Vaz I,Marques J,Demoly P,Polónia J,Gomes ER

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:This paper describes a method to determine the number of patients and the number of blood levels which are appropriate for a pharmacokinetic population analysis. METHODS:We studied this question by performing 203 runs of population analysis, using the NPEM algorithm with a one compartment model, starting wit...

journal_title：European journal of clinical pharmacology

authors： Bréant V,Charpiat B,Sab JM,Maire P,Jelliffe RW

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved ...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Guasti L,Maresca A,Mirabile M,Contini S,Grandi AM,Marino F,Cosentino M

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS:Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 femal...

journal_title：European journal of clinical pharmacology

authors： Bosone D,Fogari R,Zoppi A,D'Angelo A,Ghiotto N,Perini G,Ramusino MC,Costa A

更新日期：2018-08-01 00:00:00

abstract：:Deuterated methadone (M-d3) and GCMS were used to study the pharmacokinetics of methadone (M) during the induction stage of methadone maintenance treatment (MMT). A pulse dose of M-d3 was given on Days 1 and 25 of two dosage regimens, one with a continuous 30 mg dose (n = 6), and the other with 30 mg for 10 days, foll...

journal_title：European journal of clinical pharmacology

authors： Nilsson MI,Anggård E,Holmstrand J,Gunne LM

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:To investigate pharmacokinetics (PK) of encapsulated CPT-11, released CPT-11 and the active metabolite SN-38 following administration of IHL-305 and to identify factors that may influence IHL-305 PK. METHODS:Plasma samples from 39 patients with solid tumors were collected in a phase I study. IHL-305 was admini...

journal_title：European journal of clinical pharmacology

authors： Wu H,Infante JR,Keedy VL,Jones SF,Chan E,Bendell JC,Lee W,Zamboni BA,Ikeda S,Kodaira H,Rothenberg ML,Burris HA 3rd,Zamboni WC

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：:The effects in vitro and in vivo of triiodothyronine on certain functions of human lymphocytes and polymorphonuclear granulocytes have been investigated. Triiodothyronine was able to enhance the phagocytic capacity and chemiluminescent activity of polymorphonuclear granulocytes. PHA-P-induced 3H-thymidine incorporatio...

journal_title：European journal of clinical pharmacology

authors： Balázs C,Leövey A,Szabó M,Bakó G

更新日期：1980-01-01 00:00:00

abstract：:The pharmacokinetics of theophylline was investigated in five hyperthyroid, five hypothyroid, and five euthyroid patients, all with chronic obstructive pulmonary disease. Wide individual variability was found in theophylline kinetics, but the rate of elimination of theophylline was significantly higher in hyperthyroid...

journal_title：European journal of clinical pharmacology

authors： Pokrajac M,Simić D,Varagić VM

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:In patients with schizophrenia, risperidone and olanzapine are the two most commonly used atypical anti-psychotics. A recent meta-analysis based on randomized trials suggests that, in the long term, olanzapine can have a lower frequency of treatment discontinuation (or dropout) in comparison with risperidone....

journal_title：European journal of clinical pharmacology

authors： Pelagotti F,Santarlasci B,Vacca F,Trippoli S,Messori A

更新日期：2004-02-01 00:00:00

abstract：:Intensive monitoring of adverse drug reactions (ADR) in infants and preschool children in the paediatric outpatient unit covering the town of Karlovac (150,000 inhabitants) was performed over a period of three months. Data were obtained by physical examination of children and the history given by their parents. In all...

journal_title：European journal of clinical pharmacology

authors： Cirko-Begović A,Vrhovac B,Bakran I

更新日期：1989-01-01 00:00:00

abstract：:A 8.5-month prospective study was performed in the Rhône area of France to study the incidence of infectious diseases in children in day care, and the qualitative and quantitative aspects of drug prescriptions for young children. The families of 1.359 children agreed to participate (98.5% of those selected). During th...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Bossard N,Floret D,Gillet J,Honegger D,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmaco...

journal_title：European journal of clinical pharmacology

authors： Choi DH,Shin WG,Choi JS

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether treatment with acarbose alters the pharmacokinetics (PK) of coadministered rosiglitazone. METHODS:Sixteen healthy volunteers (24-59-years old) received a single 8-mg dose of rosiglitazone on day 1, followed by 7 days of repeat dosing with acarbose [100 mg three times daily (t.i.d.) wi...

journal_title：European journal of clinical pharmacology

authors： Miller AK,Inglis AM,Culkin KT,Jorkasky DK,Freed MI

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:To determine the effects of late pregnancy and also oestrogen supplementation on the CYP2C19-mediated biotransformation of proguanil (PG) to its active antifol triazine metabolite cycloguanil (CG). METHODS:Case control study conducted on the NW border of Thailand; a single dose of PG (4 mg/kg) was administer...

journal_title：European journal of clinical pharmacology

authors： McGready R,Stepniewska K,Seaton E,Cho T,Cho D,Ginsberg A,Edstein MD,Ashley E,Looareesuwan S,White NJ,Nosten F

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:This study evaluated the benefits of and possible contraindications to warfarin treatment in patients with atrial fibrillation (AF) prior to the introduction of new oral anticoagulants using health registry data from inpatient care, specialist ambulatory care, and primary care. METHODS:This is a cohort study i...

journal_title：European journal of clinical pharmacology

authors： Forslund T,Wettermark B,Wändell P,von Euler M,Hasselström J,Hjemdahl P

更新日期：2014-12-01 00:00:00

abstract：:The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins. Given orally for 5 days, torasemide was clinically very effective and well tolerated. On a weight basis, the diure...

journal_title：European journal of clinical pharmacology

authors： Broekhuysen J,Deger F,Douchamps J,Ducarne H,Herchuelz A

更新日期：1986-01-01 00:00:00

abstract：:Maternal and umbilical serum concentrations of atenolol, a hydrophilic, cardioselective beta-adrenoceptor antagonist, were studied at delivery in seven cases of pregnancy hypertension. The drug had been administered to each patient for at least one week. Atenolol was detected in both maternal and umbilical serum in si...

journal_title：European journal of clinical pharmacology

authors： Melander A,Niklasson B,Ingemarsson I,Liedholm H,Scherstén B,Sjöberg NO

更新日期：1978-11-16 00:00:00

abstract：:An analytical procedure for the simultaneous determination of pethidine and its N-Demethylated metabolite, norpethidine, in plasma is described. Pethidine and norpethidine are separated by partition chromatography, converted to the trichloroethyl carbamate with trichloroethyl chloroformate and determined by electron c...

journal_title：European journal of clinical pharmacology

authors： Hartvig P,Karlsson KE,Lindbert C,Boréus LO

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

journal_title：European journal of clinical pharmacology

authors： González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

更新日期：2019-06-01 00:00:00

abstract：:Interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two subacute double-blind cross-over experiments on 40 healthy, young volunteers. The drugs were administered for two week periods. The variables measured were choice reaction time and accuracy, eye-hand co-ordination, di...

journal_title：European journal of clinical pharmacology

authors： Palva ES,Linnoila M

更新日期：1978-07-30 00:00:00

abstract：:We have evaluated the pharmacokinetics of high doses of clonidine, as used in the prophylactic treatment of alcohol withdrawal syndrome, in 11 alcohol-dependent patients undergoing surgery for oesophagogastrectomy. Clonidine was given in a bolus of 150 micrograms followed by a continuous infusion. After a mean period ...

journal_title：European journal of clinical pharmacology

authors： Fauler J,Verner L

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:This study investigated the effects of clotrimazole troche on the risk of transplant rejection and the pharmacokinetics of tacrolimus. METHODS:The data mining approach was used to investigate whether the use of clotrimazole increased the risk of transplant rejection in patients receiving tacrolimus therapy. Pa...

journal_title：European journal of clinical pharmacology

authors： Uno T,Wada K,Hosomi K,Matsuda S,Ikura MM,Takenaka H,Terakawa N,Oita A,Yokoyama S,Kawase A,Takada M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...

journal_title：European journal of clinical pharmacology

authors： Boscarino C,Edginton AN,Peng H,Riggs KW,Szeitz A,Cheung B

更新日期：2013-01-01 00:00:00