Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving.

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：:The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Yamada T,Kikuchi K,Koyama E,Ishizaki T

更新日期：1993-01-01 00:00:00

abstract：:The metabolism of hydralazine in a group of slow acetylator patients with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects. There were no toxicologically significant difference in metabolite excretion between the groups which reached statistical significance, although t...

journal_title：European journal of clinical pharmacology

authors： Timbrell JA,Facchini V,Harland SJ,Mansilla-Tinoco R

更新日期：1984-01-01 00:00:00

abstract：:The systemic effects of single and multiple doses of inhaled fluticasone propionate (FP) and budesonide were examined in 24 healthy male volunteers (age range 18-29 years). The study was of an open, placebo-controlled, randomized, three-way crossover design. On each study day, multiple blood samples were taken over a ...

journal_title：European journal of clinical pharmacology

authors： Lönnebo A,Grahnén A,Jansson B,Brundin RM,Ling-Andersson A,Eckernäs SA

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to investigate in healthy male subjects the tolerability, pharmacokinetics, and pharmacodynamics of ascending doses of clazosentan, an intravenous endothelin receptor antagonist. METHODS:Clazosentan was infused at doses of 3-60 mg/h for 3 h, 60 mg/h for 6 h and at 30 mg/h for 12...

journal_title：European journal of clinical pharmacology

authors： van Giersbergen PL,Dingemanse J

更新日期：2007-02-01 00:00:00

abstract：:In a double-blind, placebo-controlled study nasal saline and histamine provocation tests were performed in patients with perennial allergic rhinitis in order to assess changes in eosinophil influx and non-specific nasal reactivity after 8 days of treatment with ipratropium bromide. A "nasal pool" method was used to tr...

journal_title：European journal of clinical pharmacology

authors： Górski P,Pazdrak K,Ruta U

更新日期：1993-01-01 00:00:00

abstract：:The chronic oral administration of 0.07 mg digitoxin o.d. for up to 58 days to 12 healthy volunteers caused a small drop in mean heart rate HR (95% CI: -7.9 to -1.6 beats.min-1), in mean diastolic blood pressure (95% CI: -8.3 to -0.4 mmHg), shortening of the QTc-interval (95% CI: -42 to -19 ms), shortening of the HR-c...

journal_title：European journal of clinical pharmacology

authors： de Mey C,Elich D,Schroeter V,Butzer R,Belz GG

更新日期：1992-01-01 00:00:00

abstract：:The kinetics of 14C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9 +/- 1.61 (X +/- SE), from which its elimination could be described using three-compartment open model. The elimination half-life...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Neuvonen PJ,Penttilä A

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVES:Problem-oriented drug information is characterised by health professionals actively seeking drug information through various sources. In this study our objective was to determine the quality and impact of problem-oriented drug information among physicians. METHODS:Evaluation forms accompanying 163 written a...

journal_title：European journal of clinical pharmacology

authors： Schjøtt J,Pomp E,Gedde-Dahl A

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the effect of 7 days treatment with nimesulide on bleeding time. Blood coagulation, von Willebrand factor and platelet aggregation ex vivo were investigated as a secondary objective. METHOD:A randomised, double-blind, placebo-controlled, parallel group, single centre stu...

journal_title：European journal of clinical pharmacology

authors： Marbet GA,Yasikoff Strub ML,Macciocchi A,Tsakiris DA

更新日期：1998-07-01 00:00:00

abstract：:The pharmacokinetics of a single 2 mg IV dose of chlordesmethyldiazepam has been studied in 11 patients with renal failure on regular haemodialysis and in 11 age-matched healthy controls. The kinetics was also examined after a single 2 mg oral dose in 6 of the 11 renal failure patients. After intravenous administratio...

journal_title：European journal of clinical pharmacology

authors： Sennesael J,Verbeelen D,Vanhaelst L,Pirola R,Bareggi SR

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. OBJECTIVES:To determine the relative frequencies of different risk factors for OA overdose including di...

journal_title：European journal of clinical pharmacology

authors： Verstuyft C,Robert A,Morin S,Loriot MA,Flahault A,Beaune P,Funck-Brentano C,Jaillon P,Becquemont L

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

journal_title：European journal of clinical pharmacology

authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

更新日期：2011-08-01 00:00:00

abstract：:Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP,Forfang K

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor (ARNI) indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction. This study was aimed to evaluate ...

journal_title：European journal of clinical pharmacology

authors： Langenickel TH,Jordaan P,Petruck J,Kode K,Pal P,Vaidya S,Chandra P,Rajman I

更新日期：2016-08-01 00:00:00

abstract：:Dexmedetomidine is a novel alpha 2-adrenoceptor agonist that may provide beneficial effects as premedication for anesthesia. The pharmacokinetics and pharmacodynamics of transdermal (TD) and intravenous (i.v.) dexmedetomidine were studied in nine healthy male subjects in a crossover trial. The TD preparation, containi...

journal_title：European journal of clinical pharmacology

authors： Kivistö KT,Kallio A,Neuvonen PJ

更新日期：1994-01-01 00:00:00

abstract：:In a cross-over pharmacokinetic study in 8 healthy volunteers a retard formulation containing pindolol 30 mg was compared with the normal 15 mg. pindolol tablet. The pindolol 30 mg retard tablet led to the same maximum plasma level as a single dose of the normal pindolol tablet. A plasma concentration higher than half...

journal_title：European journal of clinical pharmacology

authors： Aellig WH,Nüesch E,Pacha W

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To study the effect of renal impairment on the pharmacokinetics of sertindole. METHODS:A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creati...

journal_title：European journal of clinical pharmacology

authors： Wong SL,Menacherry S,Mulford D,Schmitz PJ,Locke C,Granneman GR

更新日期：1997-01-01 00:00:00

abstract：:A 8.5-month prospective study was performed in the Rhône area of France to study the incidence of infectious diseases in children in day care, and the qualitative and quantitative aspects of drug prescriptions for young children. The families of 1.359 children agreed to participate (98.5% of those selected). During th...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Bossard N,Floret D,Gillet J,Honegger D,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Drug-induced immune thrombocytopaenia is a rare, serious condition that can be triggered by numerous medications. To characterize the spectrum of drugs associated with immune thrombocytopaenia (ITP) in the Berlin Case-Control Surveillance Study (FAKOS). METHODS:Adult hospitalized patients with new onset idiopa...

journal_title：European journal of clinical pharmacology

authors： Garbe E,Andersohn F,Bronder E,Salama A,Klimpel A,Thomae M,Schrezenmeier H,Hildebrandt M,Späth-Schwalbe E,Grüneisen A,Meyer O,Kurtal H

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

journal_title：European journal of clinical pharmacology

authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:To determine the patterns of consumption in calcium channel blockers (CCB) groups in the Czech Republic between 1992 and 1999 and make a comparison with selected countries. METHODS:This was part of a drug utilization study using WHO methodology [Anatomical Therapeutic Chemical classification/defined daily do...

journal_title：European journal of clinical pharmacology

authors： Dolezal T,Nemecek K,Krsiak M

更新日期：2002-10-01 00:00:00

abstract：:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single...

journal_title：European journal of clinical pharmacology

authors： Melander O,Lidén A,Melander A

更新日期：1995-01-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

journal_title：European journal of clinical pharmacology

authors： Gao HY,Li Wan Po A

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. METHODS:Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer; initially alone and 9 d...

journal_title：European journal of clinical pharmacology

authors： Bayés MC,Barbanoj MJ,Vallès J,Torrent J,Obach R,Jané F

更新日期：1996-01-01 00:00:00

abstract：:The frequency distribution of the 8-h urinary ratio of log metoprolol/alpha-hydroxymetoprolol was assessed in 65 healthy, unrelated Jordanian volunteers. There was no apparent bimodality in the frequency distribution of this ratio among the subjects studied. The frequency of the poor metabolizer phenotype of metoprolo...

journal_title：European journal of clinical pharmacology

authors： al-Hadidi HF,Irshaid YM,Rawashdeh NM

更新日期：1994-01-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00