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Pharmacokinetic interactions of alcohol and acetylsalicylic acid.

Abstract：

:This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single-dose kinetics of 1.0 g ASA in ten fasting healthy volunteers. Plasma concentrations of ethanol were measured by gas chromatography, and those of the drugs by liquid chromatography. There was no effect of ASA, ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Melander O,Lidén A,Melander A

doi

10.1007/BF00192741

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

151-3

issue

2

eissn

0031-6970

issn

1432-1041

journal_volume

48

pub_type

临床试验,杂志文章,随机对照试验

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