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Double-blind placebo controlled clinical trial of almitrine bismesylate in patients with chronic respiratory insufficiency.

Abstract：

:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and group comparisons. Twenty three patients received almitrine 50 mg b.d. p.o. and 17 took placebo. In the almitrine group a significant increase in PaO2 was achieved (control value 54.4 mm Hg, rising to 59.1 mm Hg after 6 weeks, and to 59.4 mm Hg after 12 weeks). There was also a significant decrease in PaCO2 in the almitrine group after 12 weeks. No correlation was found between the plasma almitrine concentration, PaO2 and PaCO2. Lung function (FVC, FEV1, FEV1/FVC, Raw, TLC, RV, FRC) did not change in either group, but the degree of dyspnoea and performance in the 6 min walking test were significantly improved in the almitrine group. Adverse reactions appeared in 6 out of 23 patients on almitrine bismesylate (headache, urticaria, breathlessness, diarrhoea, chest pain, nausea and vomiting), causing drop out of 4 patients. Thus, almitrine bismesylate can be considered useful in the treatment of patients with chronic respiratory insufficiency.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

doi

10.1007/BF00315025

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

249-53

issue

3

eissn

0031-6970

issn

1432-1041

journal_volume

38

pub_type

临床试验,杂志文章,随机对照试验

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