Effect of ethanol intake on disopyramide elimination by healthy volunteers.

Abstract:

:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the urine (p less than 0.05) as well as the relative metabolic clearance of disopyramide (p less than 0.05). The renal clearance of disopyramide was increased by 19 +/- 16% (p less than 0.05) in subjects in whom ethanol caused a diuresis.

journal_name

Eur J Clin Pharmacol

authors

Olsen H,Bredesen JE,Lunde PK

doi

10.1007/BF00544024

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

103-5

issue

1

eissn

0031-6970

issn

1432-1041

journal_volume

25

pub_type

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