Abstract:
PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-risk Western medications (HRWMs) focused on in this study were antiplatelets (aspirin, clopidogrel, dipyridamole, ticlopidine), anticoagulants (heparin, warfarin), and digoxin. Concurrent use was described as having an overlapping use period of HRWM with CMs any time in 2005. Baseline demographics, comorbidities, and health service utilizations between patients with and without concurrent HRWM-CM use were compared. Logistic regression analyses were performed to identify factors associated with incident concurrent use. RESULTS:Of the 70,698 eligible HRWM users, 13.2 % used CMs concurrently for an average duration of 26.7 ± 43 days. The incidence of concurrent HRWM-CM use, which excluded prior CM use within 6 months preceding the first CM use, was 6.3 %. Warfarin or ticlopidine users were more likely to be prescribed with CMs than were the other HRWM users. Factors associated with an increasing incidence of concurrent HRWM-CM use included female sex, age 45-54 years, middle monthly income, higher number of outpatient visits or distinct prescribed medications, and a previous diagnosis of heart diseases, stroke, or hypertension. In contrast, age ≥ 65 years and higher medical expenditure were associated with a lower incidence of concurrent use. CONCLUSIONS:In the Taiwanese population, approximately one in eight HRWM users were concomitantly prescribed CMs. Whether such concurrent use is associated with adverse clinical outcomes warrants further investigations.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Tsai HH,Lin HW,Chien CR,Li TCdoi
10.1007/s00228-012-1359-6subject
Has Abstractpub_date
2013-03-01 00:00:00pages
629-39issue
3eissn
0031-6970issn
1432-1041journal_volume
69pub_type
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journal_title:European journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1007/s00228-005-0941-6
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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更新日期:2010-07-01 00:00:00
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journal_title:European journal of clinical pharmacology
pub_type: 临床试验,杂志文章
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doi:10.1007/BF00870989
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abstract::Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...
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更新日期:1990-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00228-012-1286-6
更新日期:2012-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-08-01 00:00:00
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更新日期:2015-04-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:European journal of clinical pharmacology
pub_type: 杂志文章
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journal_title:European journal of clinical pharmacology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2003-12-01 00:00:00
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更新日期:2018-02-01 00:00:00
abstract::The binding of propranolol, a drug commonly used in cardiovascular disorders, to alpha 1-acid glycoprotein (AGP) was studied in vitro in malnutrition. Compared to normal and hospital controls, the level of AGP was found to be elevated in undernourished subjects with and without infection. In the same patients the free...
journal_title:European journal of clinical pharmacology
pub_type: 杂志文章
doi:10.1007/BF00547044
更新日期:1985-01-01 00:00:00