Polypharmacy and potentially inappropriate medications: a cross-sectional analysis among 451 nursing homes in France.

abstract：:The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg.h-1 for 4 h, starting 1 to 3 h post surgery. Multiple bloo...

journal_title：European journal of clinical pharmacology

authors： Maitre PO,Funk B,Crevoisier C,Ha HR

更新日期：1989-01-01 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:We used a retrospective data mining approach to explore the association between serum amiodarone (AMD) and N-desethylamiodarone (DEA) concentrations and thyroid-related hormone levels. METHODS:Laboratory data sets from January 2012 to April 2016 were extracted from the computerized hospital information system ...

journal_title：European journal of clinical pharmacology

authors： Yamato M,Wada K,Fujimoto M,Hosomi K,Hayashi T,Oita A,Takada M

更新日期：2017-03-01 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:This paper describes a method to determine the number of patients and the number of blood levels which are appropriate for a pharmacokinetic population analysis. METHODS:We studied this question by performing 203 runs of population analysis, using the NPEM algorithm with a one compartment model, starting wit...

journal_title：European journal of clinical pharmacology

authors： Bréant V,Charpiat B,Sab JM,Maire P,Jelliffe RW

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans. METHODS:We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP...

journal_title：European journal of clinical pharmacology

authors： Minami H,Yasu T,Tagawa T,Yamakawa K,Ueda S

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS:Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 femal...

journal_title：European journal of clinical pharmacology

authors： Bosone D,Fogari R,Zoppi A,D'Angelo A,Ghiotto N,Perini G,Ramusino MC,Costa A

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk...

journal_title：European journal of clinical pharmacology

authors： Vandraas KF,Spigset O,Mahic M,Slørdal L

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

journal_title：European journal of clinical pharmacology

authors： Ott P,Ranek L,Young MA

更新日期：1998-09-01 00:00:00

abstract：:The acute effects on monophasic action potentials (MAP), QT interval, and right ventricle effective refractory period (V-ERP) of propranolol 0.2 mg.kg-1 body weight have been studied in 10 patients with coronary artery disease. The median duration of MAP at 90% repolarization (MAP90) was shortened from 238 to 228 ms a...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP

更新日期：1990-01-01 00:00:00

abstract：:Thirty patients with mild or moderate essential hypertension, and a fixed elevation of diastolic blood pressure, were randomly allocated to three groups and treated with propranolol 40 mg x 4 (Group 1), 80 mg x 4 (group 2) and 160 mg x 4 (Group 3). Blood pressure (BP), pulse rate (PR), plasma renin activity (PRA), pla...

journal_title：European journal of clinical pharmacology

authors： Pedersen EB,Kornerup HJ,Pedersen OL,Andreasen F,Bjerregaard P

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevale...

journal_title：European journal of clinical pharmacology

authors： van Orten-Luiten AC,Janse A,Dhonukshe-Rutten RA,Witkamp RF

更新日期：2016-05-01 00:00:00

abstract：:The blood level versus time curve for unchanged cimetidine after a 200 mg oral dose has been determined in 20 apparently healthy subjects, ranging from 22 to 84 years of age. A significant relationship between the area under the curve (AUC) and age was found (r = 0.81; P less than 0.001). The peak concentrations of ci...

journal_title：European journal of clinical pharmacology

authors： Redolfi A,Borgogelli E,Lodola E

更新日期：1979-05-21 00:00:00

abstract：INTRODUCTION:Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge, the pharmacokinetics of epidural hydromorphone has not been evaluated in parturients. MATERIALS AND METHODS:In thi...

journal_title：European journal of clinical pharmacology

authors： Puhto T,Kokki M,Hakomäki H,Spalding M,Gunnar T,Alahuhta S,Vakkala M

更新日期：2020-07-01 00:00:00

abstract：:The incidence of vasodilation-related events (flushing, headache, dizziness and oedema) was determined in a total of 37,670 patients treated with diltiazem, nicardipine, isradipine or amlodipine and studied by Prescription-Event Monitoring between 1984 and 1991. Event rates are expressed as the percentage of patients ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Pearce GL,Inman WH

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To study the main comedications associated with major bleeding during anticoagulant therapy with coumarins in a non-selected population under everyday circumstances. METHODS:The study population for this retrospective cohort study included all new users of phenprocoumon or acenocoumarol aged 40-80 years, dur...

journal_title：European journal of clinical pharmacology

authors： Penning-van Beest F,Erkens J,Petersen KU,Koelz HR,Herings R

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:The purpose of this study is to determine the impacts of CYP3A5 polymorphism on tacrolimus concentration and the proportion of patients within a target therapeutic range during the first week after transplantation together with the 3-month acute rejection rate in kidney transplant patients receiving a minimized...

journal_title：European journal of clinical pharmacology

authors： Yaowakulpatana K,Vadcharavivad S,Ingsathit A,Areepium N,Kantachuvesiri S,Phakdeekitcharoen B,Sukasem C,Sra-Ium S,Sumethkul V,Kitiyakara C

更新日期：2016-03-01 00:00:00

abstract：:To evaluate the possible effect of quinidine on digoxin bioavailability, the steady state digoxin kinetics was examined with and without concomitant quinidine therapy, in 7 cardiac patients after simultaneous administration of oral digoxin and intravenous [3H]-digoxin. In the presence of quinidine, the absorption rate...

journal_title：European journal of clinical pharmacology

authors： Pedersen KE,Christiansen BD,Klitgaard NA,Nielsen-Kudsk F

更新日期：1983-01-01 00:00:00

abstract：:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

更新日期：1987-01-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Spontaneous reporting of adverse drug reactions (ADRs) is one approach to increasing our knowledge on the risks of drugs in clinical practice. Under-reporting is a shortcoming of this system. OBJECTIVES:To evaluate if repeated e-mails with attachments on ADR information can affect (1) the reporting of ADRs ...

journal_title：European journal of clinical pharmacology

authors： Johansson ML,Brunlöf G,Edward C,Wallerstedt SM

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the effect of 7 days treatment with nimesulide on bleeding time. Blood coagulation, von Willebrand factor and platelet aggregation ex vivo were investigated as a secondary objective. METHOD:A randomised, double-blind, placebo-controlled, parallel group, single centre stu...

journal_title：European journal of clinical pharmacology

authors： Marbet GA,Yasikoff Strub ML,Macciocchi A,Tsakiris DA

更新日期：1998-07-01 00:00:00

abstract：AIM:Mizoribine (MZR) is an immunosuppressant for the prevention of allograft rejection in Asian countries, but the great variability in pharmacokinetics (PK) limits its clinical use. This study was to explore genetic and clinical factors that affect the MZR PK process. METHODS:Blood samples and clinical data were coll...

journal_title：European journal of clinical pharmacology

authors： Dai R,Li J,Wu J,Fu Q,Yan J,Zhong G,Wang C,Chen X,Chen P

更新日期：2021-01-01 00:00:00

abstract：:Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific a...

journal_title：European journal of clinical pharmacology

authors： Gikalov I,Bircher J

更新日期：1977-11-14 00:00:00

abstract：:In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

journal_title：European journal of clinical pharmacology

authors： Chauhan BL,Kulkarni RD

更新日期：1991-01-01 00:00:00

abstract：:The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form. The following va...

journal_title：European journal of clinical pharmacology

authors： Cotter LM,Eadie MJ,Hooper WD,Lander CM,Smith GA,Tyrer JH

更新日期：1977-12-28 00:00:00

abstract：:The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the ...

journal_title：European journal of clinical pharmacology

authors： George S,McBurney A,Cole A

更新日期：1990-01-01 00:00:00

abstract：:The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.9...

journal_title：European journal of clinical pharmacology

authors： Padrini R,Barbieri E,Piovan D,Toffoli M,Motta A,Trevi GP,Ferrari M

更新日期：1985-01-01 00:00:00

abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

journal_title：European journal of clinical pharmacology

authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

更新日期：2016-05-01 00:00:00