The effects of acute and repeated doses of zolpidem on subjective sleep, psychomotor performance and cognitive function in elderly volunteers.

abstract：:An aqueous solution of 35S-ampicillin and polyethylene glycol (PEG 4000, unabsorbable marker) was administered orally to 6 healthy subjects with gastrointestinal tubes. The minimal absorption of radioactive material, as shown by urinary excretion of label, differed markedly between subjects and averaged 44% (25-67). A...

journal_title：European journal of clinical pharmacology

authors： Swahn A

更新日期：1975-12-19 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：:This study examined dosage prescribing patterns and steady-state oxipurinol plasma concentrations in 66 patients receiving chronic allopurinol therapy. Most patients (65%) were taking 300 mg allopurinol daily, although renal impairment was common. Using published guidelines, it was estimated that 35% of patients were ...

journal_title：European journal of clinical pharmacology

authors： Peterson GM,Boyle RR,Francis HW,Oliver NW,Paterson J,von Witt RJ,Taylor GR

更新日期：1990-01-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is an event that has a detrimental impact on drug development and patient safety; therefore the identification of novel biomarkers that are both sensitive and specific to the liver would have great benefit. Inflammation is known to be associated with human cases of DILI, and given the ...

journal_title：European journal of clinical pharmacology

authors： Laverty HG,Antoine DJ,Benson C,Chaponda M,Williams D,Kevin Park B

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Alcohol dependence is a public health problem worldwide, commonly associated with withdrawal symptoms for which diazepam is a frequently used drug. We studied the effect of CYP2C19 gene polymorphisms on diazepam loading dose requirement and time to reversal of acute alcohol withdrawal symptoms. We also studied ...

journal_title：European journal of clinical pharmacology

authors： Jose M,Mathaiyan J,Kattimani S,Adithan S,Chandrasekaran A

更新日期：2016-07-01 00:00:00

abstract：:An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels in November 1993 under the auspices of the European Co-operation in Science and Technology (COST), Medicine (B1) programme. Recently developed statistical methods offer the possibility of gaining integrated informatio...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Balant LP,Mentré F,Morselli PL,Rowland M,Steimer JL,Vozeh S

更新日期：1994-01-01 00:00:00

abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

journal_title：European journal of clinical pharmacology

authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

更新日期：1988-01-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. METHODS:We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and regist...

journal_title：European journal of clinical pharmacology

authors： Kauppila M,Backman JT,Niemi M,Lapatto-Reiniluoto O

更新日期：2020-11-13 00:00:00

abstract：:Nicotine chewing gum (Nicorette 4 mg) and an identical placebo gum were administered on different days, in a double-blind cross over fashion, to 4 men, aged 25-52 years, and 4 women, aged 21-49 years, all healthy non-smokers. The subjects chewed the gum for 30 min and heart rate, blood pressure, electrocardiogram, fin...

journal_title：European journal of clinical pharmacology

authors： Nyberg G,Panfilov V,Sivertsson R,Wilhelmsen L

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To quantify pharmacokinetic (PK) and pharmacodynamic (PD) relationships of various classes of GABAA agonists in healthy volunteers, in order to investigate the sensitivity of the biomarker responses due to differing GABAA-subtype selectivity and to explore the correlation between biomarker responses and side ef...

journal_title：European journal of clinical pharmacology

authors： Ren YP,Xie RJ,Marshall S,Li L,Zhou TY,Lu W

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

journal_title：European journal of clinical pharmacology

authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate the pharmacokinetic profile of tramadol hydrochloride in neonates, born from mothers who underwent analgesia with tramadol for the relief of labour pain. METHODS:Intramuscular tramadol (100--250 mg) was administered to 22 mothers giving birth who requested pain...

journal_title：European journal of clinical pharmacology

authors： Claahsen-van der Grinten HL,Verbruggen I,van den Berg PP,Sporken JM,Kollée LA

更新日期：2005-08-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 d...

journal_title：European journal of clinical pharmacology

authors： MacFarland RT,Marcus FI,Fenster PE,Graves PE,Perrier D

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To assess relative roles of the intestinal and hepatic stereoselective metabolism of nicardipine in an oral first-pass disposal with and without grapefruit juice intake. METHODS:The kinetic profiles of (+)- and (-)-nicardipine were studied in the six normal healthy male volunteers who received oral (40 mg) ...

journal_title：European journal of clinical pharmacology

authors： Uno T,Ohkubo T,Sugawara K,Higashiyama A,Motomura S,Ishizaki T

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. METHODS:Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer; initially alone and 9 d...

journal_title：European journal of clinical pharmacology

authors： Bayés MC,Barbanoj MJ,Vallès J,Torrent J,Obach R,Jané F

更新日期：1996-01-01 00:00:00

abstract：:The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg.h-1 for 4 h, starting 1 to 3 h post surgery. Multiple bloo...

journal_title：European journal of clinical pharmacology

authors： Maitre PO,Funk B,Crevoisier C,Ha HR

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

journal_title：European journal of clinical pharmacology

authors： Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to develop a real-time reverse-transcription polymerase chain reaction (RT-PCR) methodology for the quantification of thiopurine methyltransferase (TPMT) gene expression in whole blood and compare it with the TPMT enzyme activity measured in red blood cells. METHODS:TPMT gene...

journal_title：European journal of clinical pharmacology

authors： Lindqvist M,Almer S,Peterson C,Söderkvist P

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. METHODS:Data were obtained f...

journal_title：European journal of clinical pharmacology

authors： Lawson EB,Wu JC,Baldwin RM,Ingelman-Sundberg M,Rosenborg S,Yim DS,Yin OQ,Capparelli EV,Ma JD

更新日期：2012-04-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Olaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated for ovarian and metastatic breast cancer. Increased serum creatinine levels have been observed in patients taking olaparib, but the underlying mechanism is unknown. This study aimed to investigate if patients receiving olaparib have increased...

journal_title：European journal of clinical pharmacology

authors： Bruin MAC,Korse CM,van Wijnen B,de Jong VMT,Linn SC,van Triest B,Rosing H,Beijnen JH,van den Broek D,Huitema ADR

更新日期：2021-02-01 00:00:00

abstract：:The pharmacodynamic effects of torasemide, a new potent loop diuretic, were compared with those of furosemide in a double blind controlled study in 18 hypertensive patients with oedema of various origins. Given orally for 5 days, torasemide was clinically very effective and well tolerated. On a weight basis, the diure...

journal_title：European journal of clinical pharmacology

authors： Broekhuysen J,Deger F,Douchamps J,Ducarne H,Herchuelz A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to clarify the stereoselective properties in lansoprazole metabolism by monitoring the metabolic consumption for each enantiomer and the formation of the main metabolites, lansoprazole sulfone and 5-hydroxylansoprazole, in the presence of human liver microsomal enzymes. METH...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Hamada A,Nakamura C,Arimori K,Nakano M

更新日期：2001-12-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels per...

journal_title：European journal of clinical pharmacology

authors： Mulder H,Schopman W Sr,van der Lely AJ

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:This multicenter, double-blind, placebo-controlled, parallel-group study was designed to assess the acute effects of intravenous mibefradil on the electrophysiologic characteristics of the human heart. METHODS:Seventy-one patients referred for routine electrophysiologic testing were randomized to receive one...

journal_title：European journal of clinical pharmacology

authors： Rosenquist M,Brembilla-Perrot B,Meinertz T,Neugebauer A,Crijns HJ,Smeets JL,van der Vring JA,Fromer M,Kobrin I

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The continuous growth of antidepressant consumption and expenditure, especially for selective serotonin reuptake inhibitors (SSRIs), has led to the adoption of several policy measures directed toward cost control in Western countries. In Italy, copayment policies have been heterogeneously introduced at a region...

journal_title：European journal of clinical pharmacology

authors： Damiani G,Federico B,Silvestrini G,Bianchi CB,Anselmi A,Iodice L,Ronconi A,Navarra P,Da Cas R,Raschetti R,Ricciardi W

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00