Extrapancreatic insulin effect of glibenclamide.

Abstract:

:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels persisted longer after glibenclamide. The initial rise in serum insulin was of the same magnitude in both situations, as was the rise in serum C-peptide levels during the entire 5 h study. It is concluded that glibenclamide is able to maintain a more prolonged increase in serum insulin levels by inhibiting the degradation of insulin in the vascular endothelial cells of the liver. The inhibition contributes to the blood glucose lowering effect of glibenclamide.

journal_name

Eur J Clin Pharmacol

authors

Mulder H,Schopman W Sr,van der Lely AJ

doi

10.1007/BF00265847

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

379-81

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

40

pub_type

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