Pharmacokinetics of aspirin and salicylate in elderly subjects and in patients with alcoholic liver disease.

abstract：:Differences in the plasma concentrations of drugs after oral administration are caused by two main factors: variation in absorption ratios and in the distribution processes in the body. A new method for the dissection of both types of factors is discussed. The method uses a reference regression of the AUC-values to th...

journal_title：European journal of clinical pharmacology

authors： Betzien G,Kaufmann B,Schneider B

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

journal_title：European journal of clinical pharmacology

authors： Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

更新日期：2015-05-01 00:00:00

abstract：:Hemodynamic changes for 30 min after intravenous administration of molsidomin 4 mg were studied in 10 patients. Pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure and aortic pressure decreased significantly after 15 min, and after 30 min they were still below the control level. Heart rate incre...

journal_title：European journal of clinical pharmacology

authors： Karsch KR,Rentrop KP,Blanke H,Kreuzer H

更新日期：1978-06-19 00:00:00

abstract：OBJECTIVE:To investigate the CYP1A2 phenotype distribution in a population with an increased exposure to polychlorinated biphenyls (PCBs) that would likely induce an increased activity of this enzyme. Further, to investigate the effect of sex, smoking, and oral contraceptive use on the CYP1A2 activity. METHODS:In 305 ...

journal_title：European journal of clinical pharmacology

authors： Petersen MS,Halling J,Damkier P,Nielsen F,Grandjean P,Weihe P,Brøsen K

更新日期：2006-12-01 00:00:00

abstract：:Prazosin is a post synaptic alpha adrenergic blocker effective in hypertension, whose hypotensive effect is unaccompanied by reflex tachycardia or hyperreninemia, nor by other evidence of increased sympathetic activity. We studied the baroreceptor reflex arc as a potential mediator of these effects. Twenty-two essenti...

journal_title：European journal of clinical pharmacology

authors： Sasso EH,O'Connor DT

更新日期：1982-01-01 00:00:00

abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

journal_title：European journal of clinical pharmacology

authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the total healthcare costs associated with elderly chronic pain (CP) patients, define cost-related factors in this population, and examine cost evolution over two years. METHOD:This is an ancillary study from the CP S.AGE subcohort, including non-institutionalized patients aged o...

journal_title：European journal of clinical pharmacology

authors： Lazkani A,Delespierre T,Bauduceau B,Pasquier F,Bertin P,Berrut G,Corruble E,Doucet J,Falissard B,Forette F,Hanon O,Benattar-Zibi L,Piedvache C,Becquemont L

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatmen...

journal_title：European journal of clinical pharmacology

authors： Citarella A,Linder M,Kieler H,Berglind IA,Sundström A,Wettermark B,Andersen M

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To quantify the relation between local and systemic magnitudes of effects of inhaled formoterol and salbutamol. METHODS:Twenty-eight stable asthmatic patients completed this double-blind, randomised crossover study. Pre-drug administration FEV1 (mean 2.08 L) was 49-93% of predicted and reversibility 16-82% a...

journal_title：European journal of clinical pharmacology

authors： Rosenborg J,Larsson P,Rott Z,Böcskei C,Poczi M,Juhász G

更新日期：2002-07-01 00:00:00

abstract：:The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volum...

journal_title：European journal of clinical pharmacology

authors： Else OF,Sorenson H,Edwards IR

更新日期：1978-12-18 00:00:00

abstract：:A survey among hospital staff physicians was conducted in order to evaluate their attitudes towards systemic antimicrobial agents. Direct questions about the value of different agents and choice within pairs of antimicrobial drugs, stating the reasons for the preference, were included in the questionnaire used. Gentam...

journal_title：European journal of clinical pharmacology

authors： Gómez J,Erill S

更新日期：1979-03-26 00:00:00

abstract：PURPOSE:We assessed possible drug interactions of tramadol given concomitantly with the potent CYP2B6 inhibitor ticlopidine, alone or together with the potent CYP3A4 and P-glycoprotein inhibitor itraconazole. METHODS:In a randomized, placebo-controlled cross-over study, 12 healthy subjects ingested 50 mg of tramadol a...

journal_title：European journal of clinical pharmacology

authors： Hagelberg NM,Saarikoski T,Saari TI,Neuvonen M,Neuvonen PJ,Turpeinen M,Scheinin M,Laine K,Olkkola KT

更新日期：2013-04-01 00:00:00

abstract：:Nicotine chewing gum (Nicorette 4 mg) and an identical placebo gum were administered on different days, in a double-blind cross over fashion, to 4 men, aged 25-52 years, and 4 women, aged 21-49 years, all healthy non-smokers. The subjects chewed the gum for 30 min and heart rate, blood pressure, electrocardiogram, fin...

journal_title：European journal of clinical pharmacology

authors： Nyberg G,Panfilov V,Sivertsson R,Wilhelmsen L

更新日期：1982-10-01 00:00:00

abstract：:Drug shortages in developed countries pose a serious public health problem and have far-reaching implications for healthcare providers and their patients. Given the current state of the market, with the limited number of manufacturers and the array of manufacturing quality issues, drug shortages have become a global c...

journal_title：European journal of clinical pharmacology

authors： Dill S,Ahn J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Xanthine oxidase (XO) is one of the two interconvertible forms of xanthine oxidoreductase and well-studied for its role in purine catabolism and that of other purine analogues, drugs especially. Our study investigated the incidence of polymorphism in phenotypes along with the influence of gender and age on e...

journal_title：European journal of clinical pharmacology

authors： Adehin A,Bolaji OO

更新日期：2015-06-01 00:00:00

abstract：:Maternal and umbilical serum concentrations of atenolol, a hydrophilic, cardioselective beta-adrenoceptor antagonist, were studied at delivery in seven cases of pregnancy hypertension. The drug had been administered to each patient for at least one week. Atenolol was detected in both maternal and umbilical serum in si...

journal_title：European journal of clinical pharmacology

authors： Melander A,Niklasson B,Ingemarsson I,Liedholm H,Scherstén B,Sjöberg NO

更新日期：1978-11-16 00:00:00

abstract：PURPOSE:Hyperthermia occurs when heat accumulation surpasses the body's ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. METHODS:A comprehensive search was...

journal_title：European journal of clinical pharmacology

authors： Bongers KS,Salahudeen MS,Peterson GM

更新日期：2020-01-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：:Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration - time data were analysed by three different pharmacokinetic techniques. However as...

journal_title：European journal of clinical pharmacology

authors： Lander CM,Smith MT,Chalk JB,de Wytt C,Symoniw P,Livingstone I,Eadie MJ

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：:Since little is known of the number and types of binding sites on alpha 1-acid glycoprotein (AAG) and because drug-drug protein binding interactions often fail to fit a simple model, a study of the effect of 9 known AAG binding drugs on lidocaine free fraction (LFF) was performed. Serum was obtained from 10 healthy ma...

journal_title：European journal of clinical pharmacology

authors： Goolkasian DL,Slaughter RL,Edwards DJ,Lalka D

更新日期：1983-01-01 00:00:00

abstract：:The most important cardiovascular interactions between cardioactive drugs and monoamino-oxidase inhibitors or tricyclic antidepressants are reviewed. Post-ganglion blocking agents (e.g., guanethidine), clonidine, reserpine, and alpha-methyl-dopa should not be used in patients needing antide-present therapy. For hypert...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Agué C

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to determine whether mefenamic acid and salicylic acid inhibit the sulfation of (-)-salbutamol and minoxidil in the human liver and duodenum, and if so, to ascertain whether the 50% inhibitory concentration (IC50) estimates are different in the two tissues. METHODS:Sulfotran...

journal_title：European journal of clinical pharmacology

authors： Vietri M,Pietrabissa A,Spisni R,Mosca F,Pacifici GM

更新日期：2000-09-01 00:00:00

abstract：:The interaction between the main components of the new glycopeptide antibiotic teicoplanin, A2-2, A2-3, A2-4, A2-5 and A3-1, and human serum albumin has been studied in vitro by equilibrium dialysis (pH 7.4, 37 degrees C). From Scatchard analysis of the data, the calculated association constants (Ka) were: A2-2, 2.47 ...

journal_title：European journal of clinical pharmacology

authors： Assandri A,Bernareggi A

更新日期：1987-01-01 00:00:00

abstract：:Eighty patients recovering from major operations were investigated to evaluate the influence of naloxone on the analgesic and respiratory depressant properties of buprenorphine. They were randomly assigned to two groups to self-administer either buprenorphine (Group B) or a mixture of buprenorphine and naloxone (fract...

journal_title：European journal of clinical pharmacology

authors： Lehmann KA,Reichling U,Wirtz R

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in ongoing efforts to optimise dosage recommendations in clinical practise. This study was performed to further identify the cytochrome P(450) (CYP) enzymes that metabolise major APDs and evaluate the possibility of predicting in vi...

journal_title：European journal of clinical pharmacology

authors： Li XQ,Björkman A,Andersson TB,Gustafsson LL,Masimirembwa CM

更新日期：2003-09-01 00:00:00

abstract：:The relationship between the serum protein binding of carbamazepine (CBZ) and carbamazepine-10,11 epoxide (CBZ-E) and the concentration of alpha 1-acid glycoprotein (AAG) and albumin (HSA) was examined in 39 CBZ-treated epileptic children aged 4 months to 12 years. A significant inverse correlation was found between t...

journal_title：European journal of clinical pharmacology

authors： Contin M,Riva R,Albani F,Perucca E,Lamontanara G,Baruzzi A

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To describe trends in opioid consumption in Israel (morphine, methadone, oxycodone, pethidine, fentanyl, buprenorphine, codeine, and dextropropoxyphene) over the 9 years, 2000-2008, and to explore explanations for changes in consumption, in amounts and the pattern. METHODS:Data for the 2000-2008 period (all ...

journal_title：European journal of clinical pharmacology

authors： Ponizovsky AM,Marom E,Zeldin A,Cherny NI

更新日期：2011-02-01 00:00:00

abstract：AIM:To analyse the consumption of a number of medicines with a known potential for increasing the risk of road traffic accidents in the general population of Europe. METHODS:Questionnaires were distributed through the European Drug Utilization Research Group (EuroDURG) and Post-Innovation Learning through Life-events ...

journal_title：European journal of clinical pharmacology

authors： Ravera S,Hummel SA,Stolk P,Heerdink RE,de Jong-van den Berg LT,de Gier JJ

更新日期：2009-11-01 00:00:00

abstract：:The cardiovascular and endocrine profile of cromakalim has been studied in 8 healthy men (age 25 +/- 2 years: means SEM) and its influence on renin release from cultured rat juxtaglomerular cells in vitro has also been examined. According to a double-blind, randomized sequence the subjects received placebo or cromakal...

journal_title：European journal of clinical pharmacology

authors： Ferrier CP,Kurtz A,Lehner P,Shaw SG,Pusterla C,Saxenhofer H,Weidmann P

更新日期：1989-01-01 00:00:00