Abstract:
:Hemodynamic changes for 30 min after intravenous administration of molsidomin 4 mg were studied in 10 patients. Pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure and aortic pressure decreased significantly after 15 min, and after 30 min they were still below the control level. Heart rate increased significantly (by 15%) 15 min after injection, and after 30 min it was still 8% above the control value. Cardiac index decreased significantly from 3.37 +/- 0.12 to 2.95 +/- 0.15 1/min/m2. Peripheral and pulmonary resistance showed no significant change. Both stroke work index and minute work decreased significantly 15 min after administration of molsidomin and after 30 min both were still below the control level. The results suggest that molsidomin decreases preload without influencing afterload. By decreasing preload, molsidomin improves the oxygen supply/demand ratio of the myocardium.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Karsch KR,Rentrop KP,Blanke H,Kreuzer Hdoi
10.1007/BF00716357subject
Has Abstractpub_date
1978-06-19 00:00:00pages
241-5issue
4eissn
0031-6970issn
1432-1041journal_volume
13pub_type
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journal_title:European journal of clinical pharmacology
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