Correction to: Pharmacoepidemiology resources in Ireland-an introduction to pharmacy claims data.

abstract：PURPOSE:The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS:Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 femal...

journal_title：European journal of clinical pharmacology

authors： Bosone D,Fogari R,Zoppi A,D'Angelo A,Ghiotto N,Perini G,Ramusino MC,Costa A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The aim was to develop a model to describe the population pharmacokinetics of nevirapine in South African human immunodeficiency virus (HIV)-infected patients who were taking nevirapine-based antiretroviral therapy concomitantly or in the absence of rifampicin-based tuberculosis therapy. METHODS:Patients wer...

journal_title：European journal of clinical pharmacology

authors： Elsherbiny D,Cohen K,Jansson B,Smith P,McIlleron H,Simonsson US

更新日期：2009-01-01 00:00:00

abstract：:Differences in the plasma concentrations of drugs after oral administration are caused by two main factors: variation in absorption ratios and in the distribution processes in the body. A new method for the dissection of both types of factors is discussed. The method uses a reference regression of the AUC-values to th...

journal_title：European journal of clinical pharmacology

authors： Betzien G,Kaufmann B,Schneider B

更新日期：1982-01-01 00:00:00

abstract：:A survey among hospital staff physicians was conducted in order to evaluate their attitudes towards systemic antimicrobial agents. Direct questions about the value of different agents and choice within pairs of antimicrobial drugs, stating the reasons for the preference, were included in the questionnaire used. Gentam...

journal_title：European journal of clinical pharmacology

authors： Gómez J,Erill S

更新日期：1979-03-26 00:00:00

abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

journal_title：European journal of clinical pharmacology

authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Ticagrelor is a reversibly binding P2Y12 receptor antagonist for the prevention of atherothrombotic events in patients with acute coronary syndrome. Previous in vitro studies showed that ticagrelor is a substrate and inhibitor of P-glycoprotein (ABCB1). Therefore, we examined the potential interaction between d...

journal_title：European journal of clinical pharmacology

authors： Teng R,Butler K

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study. RESULTS:Both oral and intramuscular artemether were well-tol...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Na-Bangchang K,Congpuong K,Molunto P,Thanavibul A

更新日期：1997-01-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:The binding of propranolol, a drug commonly used in cardiovascular disorders, to alpha 1-acid glycoprotein (AGP) was studied in vitro in malnutrition. Compared to normal and hospital controls, the level of AGP was found to be elevated in undernourished subjects with and without infection. In the same patients the free...

journal_title：European journal of clinical pharmacology

authors： Jagadeesan V,Krishnaswamy K

更新日期：1985-01-01 00:00:00

abstract：:Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could ...

journal_title：European journal of clinical pharmacology

authors： Lameijer LD,Voermans LA,Houtzagers JJ,Chadha DR

更新日期：1981-01-01 00:00:00

abstract：:The acute effects on monophasic action potentials (MAP), QT interval, and right ventricle effective refractory period (V-ERP) of propranolol 0.2 mg.kg-1 body weight have been studied in 10 patients with coronary artery disease. The median duration of MAP at 90% repolarization (MAP90) was shortened from 238 to 228 ms a...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP

更新日期：1990-01-01 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：:The metabolic fate and ACTH-suppressant activity of two injectable dexamethasone esters, 21-phosphate and 21-sulphate, were studied in healthy men. After i.v. injection of 20mg free steroid alcohol, dexamethasone phosphate was efficiently hydrolyzed to free dexamethasone, reaching its peak plasma concentration within ...

journal_title：European journal of clinical pharmacology

authors： Miyabo S,Nakamura T,Kuwazima S,Kishida S

更新日期：1981-01-01 00:00:00

abstract：:A series of elegant experimental studies and careful clinical observation over a decade or more have led to the concept of 'infarct expansion' and 'remodelling' of the heart, culminating in a number of major mortality studies indicating the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in patients af...

journal_title：European journal of clinical pharmacology

authors： Reynolds G,Hall AS,Ball SG

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:Biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation. METHOD...

journal_title：European journal of clinical pharmacology

authors： Belpaire FM,Wijnant P,Temmerman A,Rasmussen BB,Brøsen K

更新日期：1998-05-01 00:00:00

abstract：:Plasma concentrations of nitrazepam were measured by gas-liquid chromatography in: young healthy volunteers, in geriatric and psychiatric patients and in epileptic children. The disposition of nitrazepam was described in terms of a two-compartment open model. After a single oral dose of nitrazepam 5 mg the most promin...

journal_title：European journal of clinical pharmacology

authors： Kangas L,Iisalo E,Kanto J,Lehtinen V,Pynnönen S,Ruikka I,Salminen J,Sillanpää M,Syvälahti E

更新日期：1979-04-17 00:00:00

abstract：:The kinetics and dynamics of single doses (5 mg p.o.) of the optical isomers of acenocoumarol (R-AC and S-AC) were followed in healthy subjects and the effect on them of cimetidine 800 mg/day was also investigated. The AC enantiomers differed greatly in their pharmacokinetics. The mean residence time (MRT) of R-AC was...

journal_title：European journal of clinical pharmacology

authors： Thijssen HH,Janssen GM,Baars LG

更新日期：1986-01-01 00:00:00

abstract：:Cyclofenil was given as a single oral dose of 200 mg, and also as 200 mg/day for eight days, to seven healthy female volunteers. Plasma was analyzed for the active metabolite and pharmacokinetic modelling was performed. A biological half life of 29 h was bound after the single dose and 18 h after the eighth day of con...

journal_title：European journal of clinical pharmacology

authors： Borgström L

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Zuojin Pill has been shown to inhibit the cytochrome P450 (CYP) 2D6 isoenzyme in vitro. In Chinese individuals, CYP 2D6*10 is the most common allele with reduced enzyme activity. In this study, we investigated the pharmacokinetic interaction between Zuojin Pill and the sensitive CYP2D6 probe dextromethorphan ...

journal_title：European journal of clinical pharmacology

authors： Qiu F,Liu S,Miao P,Zeng J,Zhu L,Zhao T,Ye Y,Jiang J

更新日期：2016-06-01 00:00:00

abstract：:In 6 normal volunteers given single oral doses of 250,500 and 1000 mg ticlopidine (T), the peak plasma level of unchanged drug was reached after about 2 h. There was no correlation between the plasma T level and its inhibitory effect on platelet function, expressed as % inhibition of ADP-induced aggregation. By means ...

journal_title：European journal of clinical pharmacology

authors： DiPerri T,Pasini FL,Frigerio C,Blardi P,Centini F,Messa GL,Ghezzi A,Volpi L

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α...

journal_title：European journal of clinical pharmacology

authors： Vizeli P,Meyer Zu Schwabedissen HE,Liechti ME

更新日期：2018-03-01 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Body position may influence physiological characteristics, such as perfusion, gastrointestinal function and plasma volume. These characteristics may interact with key factors determining the pharmacokinetics of drugs (dissolution, absorption, distribution, metabolism, excretion). OBJECTIVES:Based on a sys...

journal_title：European journal of clinical pharmacology

authors： Queckenberg C,Fuhr U

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor, widely prescribed for type 1 human immunodeficiency virus infection. A small proportion of individuals treated with NVP experience severe cutaneous adverse events, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)....

journal_title：European journal of clinical pharmacology

authors： Ciccacci C,Di Fusco D,Marazzi MC,Zimba I,Erba F,Novelli G,Palombi L,Borgiani P,Liotta G

更新日期：2013-11-01 00:00:00

abstract：:The aim of the study was to examine the effect of chronic angiotensin converting enzyme inhibition on haemodynamics and left ventricular performance during long-lasting exercise at the anaerobic threshold. For this purpose exercise haemodynamics and left ventricular performance were assessed in 14 physically trained h...

journal_title：European journal of clinical pharmacology

authors： Palatini P,Bongiovi S,Mario L,Mormino P,Raule G,Pessina AC

更新日期：1995-01-01 00:00:00

abstract：:Idrapril is the prototype of a new class of ACE inhibitors, characterised by the presence of a hydroxdmic group. Six untreated in-patients with essential hypertension were given single oral doses of the calcium salt of idrapril, idrapril calcium (200 mg) and placebo according to a double blind, randomised experimental...

journal_title：European journal of clinical pharmacology

authors： Taddei S,Ghiadoni L,Mattei P,Sudano I,Duranti P,Favilla S,Virdis A,Romagnoli A,Criscuoli M,Coppini A

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetics and organ distribution of i.v. and oral methylene blue, which is used to prevent ifosfamide-induced encephalopathy in oncology. METHODS:The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after i.v....

journal_title：European journal of clinical pharmacology

authors： Peter C,Hongwan D,Küpfer A,Lauterburg BH

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Triptans are contraindicated in patients with known or suspected coronary artery disease (CAD); however, few studies have evaluated triptans in patients with obstructive CAD to quantify the vasoconstrictive effect on diseased coronary vessels. METHODS:Patients undergoing percutaneous transluminal coronary a...

journal_title：European journal of clinical pharmacology

authors： Newman CM,Starkey I,Buller N,Seabra-Gomes R,Kirby S,Hettiarachchi J,Cumberland D,Hillis WS

更新日期：2005-11-01 00:00:00