The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

abstract：OBJECTIVE:To evaluate the effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects. METHODS:A single 5-mg capsule of tropisetron was administered orally to 13 healthy subjects. Plasma concentrations were determined by validated HPLC procedures and data were analyzed by using nonc...

journal_title：European journal of clinical pharmacology

authors： Kim MK,Cho JY,Lim HS,Hong KS,Chung JY,Bae KS,Oh DS,Shin SG,Lee SH,Lee DH,Min B,Jang IJ

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Sequential and concomitant therapies are two innovative therapies for Helicobacter pylori (H. pylori) eradication. However, the comparative efficacy and safety of these treatments are controversial. Therefore, we aimed to conduct an updated systematic review and meta-analysis of studies that compared these t...

journal_title：European journal of clinical pharmacology

authors： Wang Y,Zhao R,Wang B,Zhao Q,Li Z,Zhu-Ge L,Yin W,Xie Y

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

journal_title：European journal of clinical pharmacology

authors： Merkel U,Sigusch H,Hoffmann A

更新日期：1994-01-01 00:00:00

abstract：:Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...

journal_title：European journal of clinical pharmacology

authors： Lameire N,Gordts J

更新日期：1986-01-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol.kg-1.min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 micrograms.m.-1)-induced o...

journal_title：European journal of clinical pharmacology

authors： Lang CC,Lau CS,Belch JJ,Struthers AD

更新日期：1990-01-01 00:00:00

abstract：:In a cross-over pharmacokinetic study in 8 healthy volunteers a retard formulation containing pindolol 30 mg was compared with the normal 15 mg. pindolol tablet. The pindolol 30 mg retard tablet led to the same maximum plasma level as a single dose of the normal pindolol tablet. A plasma concentration higher than half...

journal_title：European journal of clinical pharmacology

authors： Aellig WH,Nüesch E,Pacha W

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:To gain insight into the experiences and handling of adverse drug reactions (ADRs) by the staffs of public primary healthcare (PHC) clinics in Eastern Cape Province, South Africa, as well as their perceptions of related adherence challenges in the treatment and follow-up of human immunodeficiency virus (HIV)-po...

journal_title：European journal of clinical pharmacology

authors： Ruud KW,Srinivas SC,Toverud EL

更新日期：2012-09-01 00:00:00

abstract：:The pharmacokinetics, hypotensive effect and tolerability of a new vasodilator, tolmesoxide (T), have been studied in 6 uncontrolled hypertensive patients receiving atenolol and diuretic. After a 50 mg oral dose mean (+/- SD) peak plasma concentration of T was 1.13 +/- 0.29 micrograms/ml-1 and occurred 0.79 +/- 0.40 h...

journal_title：European journal of clinical pharmacology

authors： Silas JH,Phillips FC,Freestone S,Tucker GT,Ramsay LE

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The continuous growth of antidepressant consumption and expenditure, especially for selective serotonin reuptake inhibitors (SSRIs), has led to the adoption of several policy measures directed toward cost control in Western countries. In Italy, copayment policies have been heterogeneously introduced at a region...

journal_title：European journal of clinical pharmacology

authors： Damiani G,Federico B,Silvestrini G,Bianchi CB,Anselmi A,Iodice L,Ronconi A,Navarra P,Da Cas R,Raschetti R,Ricciardi W

更新日期：2013-04-01 00:00:00

abstract：:6beta-Hydroxycortisol (6beta-OHF) urinary excretion has, for a long time, been considered a marker of drug induction and, more recently, of drug inhibition in humans and in laboratory animals, but its specificity is still under debate. In this work, we review 277 papers devoted to 6beta-OHF urinary excretion. We have ...

journal_title：European journal of clinical pharmacology

authors： Galteau MM,Shamsa F

更新日期：2003-12-01 00:00:00

abstract：PURPOSE:The quality of drug therapy is an important issue for nursing homes. This study aimed to assess the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in a large sample of nursing home residents by using the data recorded during the preparation of pill dispensers. METHODS:This is a cro...

journal_title：European journal of clinical pharmacology

authors： Herr M,Grondin H,Sanchez S,Armaingaud D,Blochet C,Vial A,Denormandie P,Ankri J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the contributions of non-genetic and genetic factors on the variability of stable warfarin doses in Thai patients. METHODS:A total of 250 Thai patients with stable warfarin doses were enrolled in the study. Demographics and clinical data, e.g., age, body mass index, ind...

journal_title：European journal of clinical pharmacology

authors： Wattanachai N,Kaewmoongkun S,Pussadhamma B,Makarawate P,Wongvipaporn C,Kiatchoosakun S,Vannaprasaht S,Tassaneeyakul W

更新日期：2017-08-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

更新日期：1985-01-01 00:00:00

abstract：:Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension. The effects on blood pressure were measured (Riva Rocci) before medication and after 2 h with the patient in a lying and standing position after 4 weeks of...

journal_title：European journal of clinical pharmacology

authors： Krönig B,Widmann L,Staiger C,Machwirth M,Stienen U,Hennig M,Müller-Beckmann B

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of repaglinide, a novel oral prandial glucose regulator, with that of glibenclamide, an oral hypoglycaemic agent, in the treatment of patients with type 2 diabetes. METHODS:This was a 14-week, double-blind, parallel-group trail in which a total of 195 type 2 diabetic patien...

journal_title：European journal of clinical pharmacology

authors： Landgraf R,Bilo HJ,Müller PG

更新日期：1999-05-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：:The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight h...

journal_title：European journal of clinical pharmacology

authors： Gasic S,Korn A,Eichler HG,Oberhummer I,Zapotoczky HG

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Case report of a pharmacokinetic interaction between diltiazem and nortriptyline. METHODS:Determination of plasma nortriptyline concentrations by HPLC. Calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring. RESULTS:The average plasma concentration of...

journal_title：European journal of clinical pharmacology

authors： Krähenbühl S,Smith-Gamble V,Hoppel CL

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:Iatrogenesis is common in elderly patients. This phenomenon could be reduced by improving awareness of general practitioners (GPs). We studied GPs' prescribing behavior to elderly patients, to identify GP and patient characteristics related to cautious prescribing behaviors. METHODS:The observational study ...

journal_title：European journal of clinical pharmacology

authors： Fantino B,Voirin N,Laforest L,Fantino F,Chretin S,Van Ganse E

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:The prevention of contrast-mediated nephropathy (CMN), which accounts for considerable morbidity and mortality, remains a vexing problem. Contrast induced renal vasoconstriction is believed to play a pivotal role in the CMN mechanism. The aim of this pilot study was to examine the safety and efficacy of two d...

journal_title：European journal of clinical pharmacology

authors： Spargias K,Adreanides E,Giamouzis G,Karagiannis S,Gouziouta A,Manginas A,Voudris V,Pavlides G,Cokkinos DV

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

journal_title：European journal of clinical pharmacology

authors： Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS:This meta-analysis was done through four phases: (1) Identification...

journal_title：European journal of clinical pharmacology

authors： Nguyen KA,Li L,Lu D,Yazdanparast A,Wang L,Kreutz RP,Whipple EC,Schleyer TK

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:This paper describes a method to determine the number of patients and the number of blood levels which are appropriate for a pharmacokinetic population analysis. METHODS:We studied this question by performing 203 runs of population analysis, using the NPEM algorithm with a one compartment model, starting wit...

journal_title：European journal of clinical pharmacology

authors： Bréant V,Charpiat B,Sab JM,Maire P,Jelliffe RW

更新日期：1996-01-01 00:00:00

abstract：:The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR values were bimodally d...

journal_title：European journal of clinical pharmacology

authors： Veronese ME,McLean S

更新日期：1991-01-01 00:00:00