Blood-pressure-lowering effect of carvedilol vs nitrendipine in geriatric hypertensives.

abstract：:The systemic availability of oral zidovudine has been studied in 13 patients with the acquired immunodeficiency syndrome (AIDS) dosed either fasting or with breakfast. The mean peak plasma concentration and AUC of zidovudine were significantly 2.8- and 1.4-times higher in fasting patients than in those treated during ...

journal_title：European journal of clinical pharmacology

authors： Lotterer E,Ruhnke M,Trautmann M,Beyer R,Bauer FE

更新日期：1991-01-01 00:00:00

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：:The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

journal_title：European journal of clinical pharmacology

authors： Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

更新日期：1987-01-01 00:00:00

abstract：:In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

journal_title：European journal of clinical pharmacology

authors： Chauhan BL,Kulkarni RD

更新日期：1991-01-01 00:00:00

abstract：:The pharmacokinetics of 3H-16-epi-gitoxin have been investigated after oral administration: The peak serum level occurred after 30-60 min, and its subsequent decline was in two phases with half-lives of 3.5 and 19.5 h, respectively. Within 3 days 66-70% of the administered radioactivity were eliminated by renal excret...

journal_title：European journal of clinical pharmacology

authors： Haustein KO

更新日期：1977-07-19 00:00:00

abstract：PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

journal_title：European journal of clinical pharmacology

authors： González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

journal_title：European journal of clinical pharmacology

authors： Mills PR,Weidmann AE,Stewart D

更新日期：2017-10-01 00:00:00

abstract：:Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a...

journal_title：European journal of clinical pharmacology

authors： Schnack C,Röggla G,Luger A,Schernthaner G

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS:This meta-analysis was done through four phases: (1) Identification...

journal_title：European journal of clinical pharmacology

authors： Nguyen KA,Li L,Lu D,Yazdanparast A,Wang L,Kreutz RP,Whipple EC,Schleyer TK

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：:Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was decreased. The ch...

journal_title：European journal of clinical pharmacology

authors： Elmgreen J,Tougaard L,Leth A,Christensen MS

更新日期：1980-10-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

journal_title：European journal of clinical pharmacology

authors： Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) w...

journal_title：European journal of clinical pharmacology

authors： Orme M,Sjöqvist F

更新日期：2013-09-01 00:00:00

abstract：:The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

journal_title：European journal of clinical pharmacology

authors： Coller JK,Christrup LL,Somogyi AA

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS:Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-D...

journal_title：European journal of clinical pharmacology

authors： Vanderkam P,Blanchard C,Naudet F,Pouchain D,Vaillant Roussel H,Perault-Pochat MC,Jaafari N,Boussageon R

更新日期：2019-05-01 00:00:00

abstract：AIMS:To determine whether the variability in cytochrome P(450) (CYP)3A4 metabolic function is exhibited at both transcription and translation levels and to examine the population distribution of CYP3A4 enzyme kinetics, protein, and mRNA. METHODS:Enzyme kinetics of testosterone 6beta-hydroxylation, immunoblot CYP3A4 pr...

journal_title：European journal of clinical pharmacology

authors： Sy SK,Ciaccia A,Li W,Roberts EA,Okey A,Kalow W,Tang BK

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

journal_title：European journal of clinical pharmacology

authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

更新日期：2001-11-01 00:00:00

abstract：:In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate variation to standard s...

journal_title：European journal of clinical pharmacology

authors： Myllylä VV,Sotaniemi KA,Illi A,Suominen K,Keränen T

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined the influence of the CYP2D6*10 allele on MX pharmacokinetic...

journal_title：European journal of clinical pharmacology

authors： Otani M,Fukuda T,Naohara M,Maune H,Senda C,Yamamoto I,Azuma J

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：:In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Follo...

journal_title：European journal of clinical pharmacology

authors： Seymour RA,Williams FM,Oxley A,Ward A,Fearns M,Brighan K,Rawlins MD,Jones PM

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:In order to document the stereoselective distribution in joints of a chiral nonsteroidal anti-inflammatory drug, the relative affinities of the enantiomers of tiaprofenic acid in synovium and for cartilage were compared. METHODS:The distribution of tiaprofenic acid in synovium and in cartilage was studied 25...

journal_title：European journal of clinical pharmacology

authors： Lapicque F,Mainard D,Gillet P,Payan E,Bannwarth B,Netter P

更新日期：1996-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

journal_title：European journal of clinical pharmacology

authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

更新日期：2016-05-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：:The pharmacokinetics of i.v. chloramphenicol succinate and oral chloramphenicol palmitate were studied in Ethiopian children with different nutritional states. In children with kwashiorkor the plasma clearance of chloramphenicol was significantly lower than in children of normal weight (4.16 ml/min/kg versus 7.53 ml/m...

journal_title：European journal of clinical pharmacology

authors： Eriksson M,Paalzow L,Bolme P,Mariam TW

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

journal_title：European journal of clinical pharmacology

authors： Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

更新日期：2016-03-01 00:00:00

abstract：:The most convenient route of drug administration is peroral. To reach their target, drug molecules must be absorbed from the gastrointestinal tract and enter the systemic circulation in sufficient quantities. For this reason, understanding and anticipating the mechanisms and factors affecting gastrointestinal absorpti...

journal_title：European journal of clinical pharmacology

authors： Pelkonen O,Boobis AR,Gundert-Remy U,Action COST B15 Working Group 1.

更新日期：2001-11-01 00:00:00