Pharmacokinetic interaction between diltiazem and nortriptyline.

abstract：OBJECTIVE:We sought to quantify the influence of the CYP3A inhibitor erythromycin on the pharmacokinetics of everolimus, a CYP3A substrate. METHODS:This was a two-period, single-sequence, crossover study in 16 healthy subjects. In period 1, subjects received the reference treatment of a single 2-mg dose of everolimus....

journal_title：European journal of clinical pharmacology

authors： Kovarik JM,Beyer D,Bizot MN,Jiang Q,Shenouda M,Schmouder RL

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVES:This study was conducted to examine a complex effect of ciprofibrate therapy in patients with atherogenic lipoprotein phenotype. METHODS:Effects of ciprofibrate were studied on HDL subpopulations, HDL ability to esterify cholesterol (FER(HDL)), susceptibility of LDL to oxidation as well as on in vivo oxidat...

journal_title：European journal of clinical pharmacology

authors： Raslová K,Dobiásová M,Nagyová A,Fábry R,Rauchová H,Dusinská M

更新日期：1998-11-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:The antihypertensive effects of urapidil and clonidine have been studied in a double-blind cross-over trial in 11 hypertensive outpatients with mild to moderate hypertension, at rest and during isometric exercise. Urapidil 30 mg b.i.d. significantly decreased the standing diastolic blood pressure (p less than 0.05) an...

journal_title：European journal of clinical pharmacology

authors： Kanniainen E,Heikkilä O,Jääskeläinen T,Lilja M,Jounela AJ

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE/METHODS:The metabolism of chloramphenicol succinate (CAPS) by human bone marrow was studied in vitro using 75 marrow samples. Whole marrow samples were incubated with CAPS with or without reduced nicotinamide adenine dinucleotide phosphate for 1, 2 and 3 h at 37 degrees C. Ficoll-paque-separated marrow mononu...

journal_title：European journal of clinical pharmacology

authors： Ambekar CS,Cheung B,Lee J,Chan LC,Liang R,Kumana CR

更新日期：2000-08-01 00:00:00

abstract：:Protein binding of phenytoin was assesed in one patient with dialysis encephalopathy before and after haemodialysis. Phenytoin concentrations were measured by radioimmunoassay and continuous ultrafiltration was used to assess phenytoin binding. At a serum concentration of 60 micromol.1-1 the percentage of phenytoin bo...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Lawrence JR,Elliott HL,Whiting B

更新日期：1979-02-19 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a ...

journal_title：European journal of clinical pharmacology

authors： Streete JM,Berry DJ,Newberry JE,Crome P

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor receptor 4 (FGFR4) expression has association with tumor malignancy. In thyroid cancers, FGFR4 has been reported to be characteristically expressed in aggressive thyroid tumors, such as anaplastic thyroid carcinoma (ATC). METHODS:We investigated FGFR4 expression in patients with ATC an...

journal_title：European journal of clinical pharmacology

authors： Yamazaki H,Yokose T,Hayashi H,Iwasaki H,Osanai S,Suganuma N,Nakayama H,Masudo K,Rino Y,Masuda M

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the effect of two of the most important functional CYP1A2 variations -3860G > A and -163C > A on carbamazepine pharmacokinetics in Serbian pediatric epileptic patients. METHODS:The study involved 40 Serbian pediatric epileptic patients on steady-state carbamazepine t...

journal_title：European journal of clinical pharmacology

authors： Djordjevic N,Milovanovic DD,Radovanovic M,Radosavljevic I,Obradovic S,Jakovljevic M,Milovanovic D,Milovanovic JR,Jankovic S

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Oncological patients are at increasing risk of QT prolongation, a risk factor for ventricular arrhythmia. We assessed impact and risk factors for corrected QT (QTc) prolongation during multiple-cycle chemotherapy. METHODS:We enrolled 100 outpatients initiating chemotherapy in a university center specializing i...

journal_title：European journal of clinical pharmacology

authors： Diemberger I,Massaro G,Cubelli M,Rubino D,Quercia S,Martignani C,Ziacchi M,Biffi M,Bernardi A,Cacciari N,Zamagni C,Boriani G

更新日期：2015-08-01 00:00:00

abstract：:Theophylline disposition after an intravenous test dose of aminophylline was determined in 83 subjects: 7 patients with and 58 without congestive heart failure (CHF), and 18 healthy controls. Based on the pharmacokinetics of theophylline in the individual, the oral dosage of aminophylline was scheduled to attain stead...

journal_title：European journal of clinical pharmacology

authors： Horai Y,Ishizaki T,Sasaki T,Watanabe M,Kabe J

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To assess the pharmacokinetics, safety and tolerability of escalating oral doses of GW420867X, a non-nucleoside reverse transcriptase inhibitor, was investigated in healthy male volunteers in a randomized, double-blind placebo-controlled study. METHODS:Study subjects were divided into four groups of 12 subje...

journal_title：European journal of clinical pharmacology

authors： Moore KH,Cass LM,Dallow N,Hardman TC,Jones A,Boyce M,Prince WT

更新日期：2001-01-01 00:00:00

abstract：:The four sulphonamides studied--furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid--bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the fou...

journal_title：European journal of clinical pharmacology

authors： Zini R,d'Athis P,Hoareau A,Tillement JP

更新日期：1976-06-15 00:00:00

abstract：:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a ...

journal_title：European journal of clinical pharmacology

authors： Colombo F,Sega R,Mailland F,Rigo R,Palvarini L,Libretti A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to analyse inter-and intra-country quantitative and qualitative differences in anti-asthmatic prescriptions to children and adolescents. METHODS:A literature search was performed in EMBASE and MEDLINE to identify pharmaco-epidemiological studies published from January 1, 2000 ...

journal_title：European journal of clinical pharmacology

authors： Bianchi M,Clavenna A,Bonati M

更新日期：2010-09-01 00:00:00

abstract：CASE REPORTS:Two women treated with agalsidase alpha for Fabry disease developed severe heart dysfunctions a few months after the beginning of enzyme replacement therapy (ERT). An adverse effect caused by the treatment was suspected; therefore we informed the French pharmacovigilance authorities about these two events....

journal_title：European journal of clinical pharmacology

authors： Mougenot P,Lidove O,Caillaud C,Arnaud P,Papo T

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to evaluate a computerised monitoring system (CMS) based on laboratory test results for the detection of adverse drug reactions (ADRs) on a paediatric ward. METHODS:A prospective, 6-month pharmacoepidemiological survey was performed on a 22-bed paediatric isolation ward. ADRs...

journal_title：European journal of clinical pharmacology

authors： Neubert A,Dormann H,Weiss J,Criegee-Rieck M,Ackermann A,Levy M,Brune K,Rascher W

更新日期：2006-11-01 00:00:00

abstract：:The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under ...

journal_title：European journal of clinical pharmacology

authors： Narang AP,Datta DV,Nath N,Mathur VS

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To describe the quantitative and qualitative changes in the utilization of oral antihyperglycemic drugs (OAHDs) between 1998 and 2004 and to analyze patients' adherence to OAHD therapy. METHODS:We conducted a retrospective analysis of the electronic database of the Hungarian National Health Fund Administrati...

journal_title：European journal of clinical pharmacology

authors： Doró P,Benko R,Kosik E,Matuz M,Tóth K,Soós G

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Serious adverse effects have been observed with some non-sedative H1-antihistamines (terfenadine and astemizole) when they were associated with drugs known to inhibit their metabolism. However, this is not a class effect, and this interaction should be considered on a case-by-case basis. The aim of this stud...

journal_title：European journal of clinical pharmacology

authors： Peytavin G,Gautran C,Otoul C,Cremieux AC,Moulaert B,Delatour F,Melac M,Strolin-Benedetti M,Farinotti R

更新日期：2005-06-01 00:00:00

abstract：:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and ...

journal_title：European journal of clinical pharmacology

authors： Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

更新日期：1990-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug ...

journal_title：European journal of clinical pharmacology

authors： Kayed K,Hansen T,Godtlibsen OB

更新日期：1977-03-11 00:00:00

abstract：:In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in ...

journal_title：European journal of clinical pharmacology

authors： Lemmer B,Scheidel B,Blume H,Becker HJ

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:The aim of therapeutic regimens using proton pump inhibitors (PPIs) in patients with acid-related diseases is to potently inhibit acid secretion for the full 24 h. However, optimum treatment is still unclear because the pharmacodynamics of PPIs differ among CYP2C19 genotypes and most of the previous studie...

journal_title：European journal of clinical pharmacology

authors： Sugimoto M,Shirai N,Nishino M,Kodaira C,Uotani T,Sahara S,Ichikawa H,Kagami T,Sugimoto K,Furuta T

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

journal_title：European journal of clinical pharmacology

authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

更新日期：2007-05-01 00:00:00

abstract：:Twenty three patients with essential hypertension who were uncontrolled on diuretic and/or beta-receptor antagonist therapy were treated additionally with the vasodilator, pinacidil, in an open study. Significant reduction in mean blood pressure was achieved. Supine and erect systolic and diastolic blood pressure fell...

journal_title：European journal of clinical pharmacology

authors： D'Arcy V,Laher M,McCoy D,Sullivan P,Walsh CH,Hickey MP

更新日期：1985-01-01 00:00:00