当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Paracetamol disposition and metabolite kinetics in patients with chronic renal failure.

Paracetamol disposition and metabolite kinetics in patients with chronic renal failure.

Abstract：

:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life of paracetamol from 2 to 8 h was similar in the 3 groups (2.1 to 2.3 h) but from 8 to 24 h it disappeared much more slowly in the renal failure patients (half-life 11.7 compared with 4.9 h in the healthy volunteers). Plasma concentrations of paracetamol glucuronide and sulphate conjugates were greatly increased in the patients with moderate renal failure and the mean plasma half-lives were 30.5 and 21.8 h respectively compared with about 3 h in the healthy volunteers. Plasma concentrations of these metabolites were even higher in the dialysis patients and there was no significant fall over 24 h. The cysteine and mercapturic acid conjugates of paracetamol could only be measured in plasma in the patients with renal failure and concentrations were very low. The fractional urinary recovery of paracetamol and its glucuronide, sulphate, cysteine and mercapturic acid conjugates was similar in healthy volunteers and patients with moderate renal failure.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

doi

10.1007/BF00558162

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

291-7

issue

3

eissn

0031-6970

issn

1432-1041

journal_volume

36

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus.

    abstract：PURPOSE:The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM). METHODS:Two-hour post-dosing concentrations of RMP, INH and PZA were determined in adult TB patients that were studie...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2132-z

    authors： Kumar AK,Chandrasekaran V,Kannan T,Murali AL,Lavanya J,Sudha V,Swaminathan S,Ramachandran G

    更新日期：2017-01-01 00:00:00

  • Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients.

    abstract：PURPOSE:Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevale...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2016-2

    authors： van Orten-Luiten AC,Janse A,Dhonukshe-Rutten RA,Witkamp RF

    更新日期：2016-05-01 00:00:00

  • The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

    abstract：OBJECTIVE:Biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation. METHOD...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050456

    authors： Belpaire FM,Wijnant P,Temmerman A,Rasmussen BB,Brøsen K

    更新日期：1998-05-01 00:00:00

  • Evaluation of the beta-adrenoceptor blocking activity of the Class Ic antiarrhythmic drug diprafenone in man.

    abstract：:The beta-adrenoceptor blocking activity of the new Class Ic-antiarrhythmic drug diprafenone has been determined in man in comparison with that of propranolol, using the standardized isoproterenol test. Following placebo, the dose of isoproterenol which increased the heart rate by 25 beats.min-1 (CD25) was 0.84 (0.1-2....

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00637739

    authors： Wagner F,Jähnchen E,Trenk D

    更新日期：1989-01-01 00:00:00

  • Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials.

    abstract：PURPOSE:To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS:Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-D...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-018-02617-6

    authors： Vanderkam P,Blanchard C,Naudet F,Pouchain D,Vaillant Roussel H,Perault-Pochat MC,Jaafari N,Boussageon R

    更新日期：2019-05-01 00:00:00

  • The pharmacokinetics of fluconazole during haemodialysis in uraemic patients.

    abstract：:We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount ext...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00265934

    authors： Oono S,Tabei K,Tetsuka T,Asano Y

    更新日期：1992-01-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00610057

    authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期：1983-01-01 00:00:00

  • Pharmacokinetics and protein binding of cefazolin in morbidly obese patients.

    abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-011-1048-x

    authors： van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

    更新日期：2011-10-01 00:00:00

  • Ursodeoxycholic acid does not affect ethinylestradiol bioavailability in women taking oral contraceptives.

    abstract：OBJECTIVE:Contraception is recommended for female patients during ursodeoxycholic acid (UDCA) treatment for the potential teratogenic effect of this bile acid, and the aim of our study was to determine whether this treatment affects the bioavailability of ethinylestradiol (EE2). METHODS:In this double-blind, randomise...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00228-004-0796-2

    authors： Baisini O,Benini F,Petraglia F,Kuhnz W,Scalia S,Marschall HU,Brunetti G,Tauschel HD,Lanzini A

    更新日期：2004-09-01 00:00:00

  • Adverse drug events in an intensive care unit of a university hospital.

    abstract：PURPOSE:Adverse drug events (ADEs) are harmful and occur with alarming frequency in critically ill patients. Complex pharmacotherapy with multiple medications increases the probability of a drug interaction (DI) and ADEs in patients in intensive care units (ICUs). The objective of the study is to determine the frequenc...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-010-0987-y

    authors： Reis AM,Cassiani SH

    更新日期：2011-06-01 00:00:00

  • Antibiotic cost reduction by providing cost information.

    abstract：:Antibiotic cost information was added to the computerized print-out for each patient of microbiology culture results, next to the antibiotic susceptibility list. During the first six months of this addition, the average monthly cost of antibiotics decreased by 16.5% ($7636) compared to the 12 months period preceding t...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558264

    authors： Rubinstein E,Barzilai A,Segev S,Samra Y,Modan M,Dickerman O,Haklai C

    更新日期：1988-01-01 00:00:00

  • DHM 32-550 in patients with angina and normal coronary arteries: dose/response relationship.

    abstract：:This is the first report of the use of DHM 32-550 a dehydrogenated peptide ergot alkaloid with both alpha and beta adrenoceptor blocking activity, in patients with angina-like chest pain. Five patients were studied to assess a dose/response relationship. No deleterious effects on blood pressure occurred at either rest...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00544034

    authors： Handler CE,Sowton E

    更新日期：1984-01-01 00:00:00

  • Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.

    abstract：:We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00315490

    authors： Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

    更新日期：1993-01-01 00:00:00

  • Accumulation of pinacidil N-oxide during chronic treatment with pinacidil.

    abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00555515

    authors： McBurney A,Henry JA,Ward JW

    更新日期：1988-01-01 00:00:00

  • Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain.

    abstract：PURPOSE:To investigate interindividual variability in response to pain treatment, we characterized postoperative patients for morphine metabolism and for COMT, OPRM1 and UGT2B7 polymorphisms. METHODS:A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OP...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-013-1523-7

    authors： De Gregori M,Garbin G,De Gregori S,Minella CE,Bugada D,Lisa A,Govoni S,Regazzi M,Allegri M,Ranzani GN

    更新日期：2013-09-01 00:00:00

  • Lack of a pharmacokinetic interaction between moexipril and hydrochlorothiazide.

    abstract：OBJECTIVE:To investigate the potential for pharmacokinetic interactions between moexipril, a new converting enzyme inhibitor, and hydrochlorothiazide after single dose administration. METHODS:12 healthy male volunteers were studied by an open, randomised, three-way cross-over design, in which single doses of moexipril...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050209

    authors： Hutt V,Michaelis K,Verbesselt R,De Schepper PJ,Salomon P,Bonn R,Cawello W,Angehrn JC

    更新日期：1996-01-01 00:00:00

  • Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction.

    abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF01037943

    authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

    更新日期：1983-01-01 00:00:00

  • Long-term effects of glipizide on insulin secretion and blood glucose control in patients with non-insulin-dependent diabetes mellitus.

    abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00314924

    authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

    更新日期：1992-01-01 00:00:00

  • Trends in paediatric macrolide use in five European countries-a population-based study.

    abstract：PURPOSE:The study aims to analyse overall as well as subgroup-specific outpatient paediatric macrolide use in five European countries, including time trends of macrolide prescription rates, and to provide potential targets for future interventions aiming to promote judicious macrolide use. METHODS:Macrolide prescripti...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1870-7

    authors： Holstiege J,Enders D,Schink T,Innocenti F,Oteri A,Bezemer I,Kaguelidou F,Molokhia M,Poluzzi E,Puccini A,Ulrichsen SP,Sturkenboom MC,Trifirò G,Garbe E

    更新日期：2015-08-01 00:00:00

  • Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients.

    abstract：OBJECTIVE:The aim of this study was to define the pharmacokinetic profile of free carbamazepine (F-CBZ) in adult Omani epileptic patients in order to improve on dosing schedules through population pharmacokinetic analysis using the NONMEM program. METHOD:Steady-state trough F-CBZ serum concentrations, carbamazepine (C...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280100300

    authors： Deleu D,Aarons L,Ahmed IA

    更新日期：2001-06-01 00:00:00

  • The importance of drug-drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France.

    abstract：PURPOSE:To quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database. METHODS:All spontaneous reports of ADRs registered in 2008 by the Midi-Pyrénées PharmacoVigilance Centre that containe...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-011-1156-7

    authors： Montastruc F,Sommet A,Bondon-Guitton E,Durrieu G,Bui E,Bagheri H,Lapeyre-Mestre M,Schmitt L,Montastruc JL

    更新日期：2012-05-01 00:00:00

  • Drug interactions between tacrolimus and clotrimazole troche: a data mining approach followed by a pharmacokinetic study.

    abstract：PURPOSE:This study investigated the effects of clotrimazole troche on the risk of transplant rejection and the pharmacokinetics of tacrolimus. METHODS:The data mining approach was used to investigate whether the use of clotrimazole increased the risk of transplant rejection in patients receiving tacrolimus therapy. Pa...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02770-6

    authors： Uno T,Wada K,Hosomi K,Matsuda S,Ikura MM,Takenaka H,Terakawa N,Oita A,Yokoyama S,Kawase A,Takada M

    更新日期：2020-01-01 00:00:00

  • Population pharmacokinetic analysis of lamivudine, stavudine and zidovudine in controlled HIV-infected patients on HAART.

    abstract：OBJECTIVE:This work aimed at building a population pharmacokinetic (PK) model for lamivudine (LMV), stavudine (STV) and zidovudine (ZDV), estimating their inter and intraindividual PK variability and investigating the influence of different covariates. METHODS:Population PK of LMV, STV and ZDV was separately evaluated...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00228-007-0337-x

    authors： Panhard X,Legrand M,Taburet AM,Diquet B,Goujard C,Mentré F,Cophar 1 - ANRS 102 Study Group.

    更新日期：2007-11-01 00:00:00

  • Influence of food on serum ambenonium concentration in patients with myasthenia gravis.

    abstract：:Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00280120

    authors： Ohtsubo K,Fujii N,Higuchi S,Aoyama T,Goto I,Tatsuhara T

    更新日期：1992-01-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of propafenone during acute and chronic administration.

    abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00614557

    authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

    更新日期：1988-01-01 00:00:00

  • Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software.

    abstract：:An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels in November 1993 under the auspices of the European Co-operation in Science and Technology (COST), Medicine (B1) programme. Recently developed statistical methods offer the possibility of gaining integrated informatio...

    journal_title：European journal of clinical pharmacology

    pub_type：

    doi：10.1007/BF00191898

    authors： Aarons L,Balant LP,Mentré F,Morselli PL,Rowland M,Steimer JL,Vozeh S

    更新日期：1994-01-01 00:00:00

  • Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels.

    abstract：OBJECTIVE:The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients. METHODS:Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinica...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-007-0388-z

    authors： Badiou S,Breton H,Peyriere H,Charasson V,Crespel A,Gelisse P,Cristol JP,Hillaire-Buys D

    更新日期：2008-01-01 00:00:00

  • Combination therapy of essential hypertension with pindolol (Visken) and hydralazine.

    abstract：:Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Visken) combined with hydralazine. Hydralazine caused a statistically significant reduction in blood pressure and an increase in pulse rate as compared with the placebo: palpitations were an i...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00614002

    authors： Persson I

    更新日期：1975-12-19 00:00:00

  • Use of cimetidine; parallels and discrepancies between the views of drug regulatory agencies and practicing physicians.

    abstract：:The use of cimetidine in general practice was studied in relation to the guidelines approved by the Dutch National Drug Regulatory Agency (DRA). National and regional figures showed that the frequency with which cimetidine was prescribed in general practice was greater than could be explained on the basis of approved ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00542346

    authors： Haayer FM,van der Werf GT,Wieringa NF,Wesseling H

    更新日期：1983-01-01 00:00:00

  • Haemodynamic effects of indenolol at rest and after a submaximal workload in essential hypertension.

    abstract：:The effect of indenolol on heart rate and blood pressure at rest and after submaximal workload has been studied in 19 patients with established essential hypertension. A stepwise increase from moderate to submaximal exercise was chosen to mimic challenges normally occurring in daily life. After 4 weeks of once a day i...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00544058

    authors： Aiello C,Groothold G,Gualtieri S,Irace L,Marini IL,Perna B,Romano A

    更新日期：1985-01-01 00:00:00