Combination therapy of essential hypertension with pindolol (Visken) and hydralazine.

abstract：PURPOSE:Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking. In this study, we describe clomipramine and desmethylclomipramine concentrations including their ratios during pr...

journal_title：European journal of clinical pharmacology

authors： Ter Horst PG,Proost JH,Smit JP,Vries MT,de Jong-van de Berg LT,Wilffert B

更新日期：2015-12-01 00:00:00

abstract：:Arginine vasopressin (AVP) is the major physiological regulator of renal water excretion and blood volume. The AVP pathways of V(1a)R-mediated vasoconstriction and V(2)R-induced water retention represent a potentially attractive target of therapy for edematous diseases. Experimental and clinical evidence suggests bene...

journal_title：European journal of clinical pharmacology

authors： Gassanov N,Semmo N,Semmo M,Nia AM,Fuhr U,Er F

更新日期：2011-04-01 00:00:00

abstract：:Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with SJW resulted in decreased plasma conce...

journal_title：European journal of clinical pharmacology

authors： Madabushi R,Frank B,Drewelow B,Derendorf H,Butterweck V

更新日期：2006-03-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00

abstract：:We have previously shown that inhaled salbutamol further increases the bronchodilator response after the maximum effect of theophylline has been obtained in patients with severe chronic bronchitis. We now report the results of adding maximally effective doses of theophylline to the maximum response obtainable from sal...

journal_title：European journal of clinical pharmacology

authors： Barclay J,Whiting B,Addis GJ

更新日期：1982-01-01 00:00:00

abstract：:Our goal was to develop a pharmacokinetic-pharmacodynamic model that describes the fate of atracurium and its metabolite laudanosine as well as the time course of the neuromuscular block. The model was based on the consideration of mass balance of atracurium and was constructed by postulating an effect compartment lin...

journal_title：European journal of clinical pharmacology

authors： Nigrovic V,Gaspari J,Banoub M

更新日期：1996-01-01 00:00:00

abstract：:Glucocorticoids (GCs) exert different activities that are useful for the treatment of several haematologic disorders. The synergistic effect with cytotoxic drugs is important for the therapy of lymphoproliferative diseases. The inhibition of macrophages prevents acute haemolysis and platelets destruction in autoimmune...

journal_title：European journal of clinical pharmacology

authors： Gobbi M,Scudeletti M

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

journal_title：European journal of clinical pharmacology

authors： Jonville-Bera AP,Autret E

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations. METHODS:Using genomic DNA sequencing, polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, the allele frequencies of CYP2A6 *1A, *1B, *2, *4A, *...

journal_title：European journal of clinical pharmacology

authors： Gyamfi MA,Fujieda M,Kiyotani K,Yamazaki H,Kamataki T

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of s...

journal_title：European journal of clinical pharmacology

authors： Couffignal C,Bertrand J,Sportiche S,Jarroir M,El Balkhi S,Djebrani-Oussedik N,Poupon J,Declèves X,Mentré F,Bellivier F

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. METHODS:We performed a retrospective analysis of alanine transaminase (ALT) levels in 481 ...

journal_title：European journal of clinical pharmacology

authors： Cai Z,Christianson AM,Ståhle L,Keisu M

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predominates in rats, leads to h...

journal_title：European journal of clinical pharmacology

authors： Hadidi H,Irshaid Y,Vågbø CB,Brunsvik A,Cholerton S,Zahlsen K,Idle JR

更新日期：1998-07-01 00:00:00

abstract：:Blood levels of racemic chloroquine and its main metabolites desethylchloroquine and bisdesethylchloroquine were measured in 29 patients treated chronically for rheumatoid arthritis. In six patients, the concentrations were followed during a one day dosage interval. There was considerable intersubject variability in t...

journal_title：European journal of clinical pharmacology

authors： Augustijns P,Geusens P,Verbeke N

更新日期：1992-01-01 00:00:00

abstract：:To evaluate the magnitude and duration of the antihypertensive effect of sustained release (SRO) isradipine, 37 uncomplicated essential hypertensive patients (diastolic blood pressure 100-115 mm Hg after a one month run-in on placebo) were randomised to receive, according to a double-blind cross-over design, isradipin...

journal_title：European journal of clinical pharmacology

authors： Arzilli F,Gandolfi E,Del Prato C,Innocenti P,Ponzanelli F,Caiazza A,Ghisoni F,Saba P,Giuntoli F,Borgnino C

更新日期：1993-01-01 00:00:00

abstract：:Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be com...

journal_title：European journal of clinical pharmacology

authors： Tfelt-Hansen P,Jansen I,Edvinsson L

更新日期：1987-01-01 00:00:00

abstract：:In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. ...

journal_title：European journal of clinical pharmacology

authors： Lechi A,Pomari S,Berto R,Buniotto P,Parrinello A,Marini F,Cogo L,Tomasi A,Baretta G

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:We used a retrospective data mining approach to explore the association between serum amiodarone (AMD) and N-desethylamiodarone (DEA) concentrations and thyroid-related hormone levels. METHODS:Laboratory data sets from January 2012 to April 2016 were extracted from the computerized hospital information system ...

journal_title：European journal of clinical pharmacology

authors： Yamato M,Wada K,Fujimoto M,Hosomi K,Hayashi T,Oita A,Takada M

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

journal_title：European journal of clinical pharmacology

authors： Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

更新日期：2010-12-01 00:00:00

abstract：:The effect of pentobarbital treatment in a mean dose of 30 mg/kg/day on the clearance of hexobarbital (Evipan) and dipyrone (Novalgin) has been evaluated in critical care patients receiving a large number of drugs as comedication. Eleven patients treated with pentobarbital showed a hexobarbital half-life of 2.79 h and...

journal_title：European journal of clinical pharmacology

authors： Heinemeyer G,Gramm HJ,Simgen W,Dennhardt R,Roots I

更新日期：1987-01-01 00:00:00

abstract：:The effects of acute and chronic administration of a slow-release preparation of pinacidil have been studied in eight normotensive volunteers aged 40-57 years. Continuous administration of 20 mg b.i.d. pinacidil had no effect on serum pinacidil concentrations measured as AUC (0-9 h), but accumulation of the principal ...

journal_title：European journal of clinical pharmacology

authors： McBurney A,Henry JA,Ward JW

更新日期：1988-01-01 00:00:00

abstract：:The immunosuppressive activity of azathioprine (AZA) is unpredictable and depends on the formation of intracellular thiopurine ribonucleotides. However, the quantification of these active thiopurines presents difficult analytical problems. It has recently been postulated that plasma concentrations of 6-thiouric acid (...

journal_title：European journal of clinical pharmacology

authors： Chan GL,Erdmann GR,Gruber SA,Stock P,Chen S,Ascher NL,Canafax DM

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The extrapolated area under the concentration-time curve (AUC0-infinity) for any drug is considered by operating guidelines as the primary parameter related to the extent of absorption in single-dose bioavailability and bioequivalence trials. Not more than 20% should be added to the experimental AUC (AUC0-t) ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Monti NC,Vuksic D

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Sequential and concomitant therapies are two innovative therapies for Helicobacter pylori (H. pylori) eradication. However, the comparative efficacy and safety of these treatments are controversial. Therefore, we aimed to conduct an updated systematic review and meta-analysis of studies that compared these t...

journal_title：European journal of clinical pharmacology

authors： Wang Y,Zhao R,Wang B,Zhao Q,Li Z,Zhu-Ge L,Yin W,Xie Y

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Tacrolimus is a commonly used immunosuppressant in solid organ transplantation recipients, but it is characterized by a narrow therapeutic range and large inter-individual variability. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of ...

journal_title：European journal of clinical pharmacology

authors： Han N,Yun HY,Hong JY,Kim IW,Ji E,Hong SH,Kim YS,Ha J,Shin WG,Oh JM

更新日期：2013-01-01 00:00:00

abstract：:The haemodynamic effects of intravenous metoprolol, over the dose-range 2.5--20 mg, were studied in 12 patients with coronary heart disease. The pharmacodynamic activity of the drug was confirmed by the suppression of exercise systolic pressure and tachycardia. There were statistically significant dose-response reduct...

journal_title：European journal of clinical pharmacology

authors： Hendry WG,Silke B,Taylor SH

更新日期：1981-01-01 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVES:To determine whether patients with idiopathic systemic lupus erythematosus (SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is an association between particular CYP2D6 genotypes and susceptibility to SLE, and whether CYP2D6 polymorphism is linked to any specific clini...

journal_title：European journal of clinical pharmacology

authors： Kortunay S,Bozkurt A,Bathum L,Basci NE,Calgüneri M,Brøsen K,Kayaalp SO

更新日期：1999-03-01 00:00:00

abstract：:The effect of AS-4370 on gastric emptying was investigated in healthy adults using 99mTc-DTPA. Single doses of AS-4370 2.5, 5 or 10 mg or placebo were administered to 12 subjects in a controlled, double-blind, cross-over study. Tests were performed twice weekly in each subject. Thirty min after administration of test ...

journal_title：European journal of clinical pharmacology

authors： Kanaizumi T,Nakano H,Matsui Y,Ishikawa H,Shimizu R,Park S,Kuriya N

更新日期：1991-01-01 00:00:00