Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH).

abstract：OBJECTIVE:To examine the association between the sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer. METHOD:Meta-analysis of case-control studies using a random effects model. The "Main outcome measure" was the odds ratio for the risk of lung cancer, using extensive metabolisers as the ...

journal_title：European journal of clinical pharmacology

authors： Christensen PM,Gøtzsche PC,Brøsen K

更新日期：1997-01-01 00:00:00

abstract：:To study the effects of enzyme induction on its pharmacokinetics, a single oral dose of the new antiarrhythmic agent mexiletine hydrochloride 400 mg was administered to 8 healthy volunteers before and after treatment with rifampicin 300 mg b.i.d. for ten days. The absorption and distribution of mexiletine were not cha...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Koivula IH,Hiltunen HA

更新日期：1982-01-01 00:00:00

abstract：:The cardiovascular and central nervous system effects of the kappa opioid receptor agonist U-62066E were investigated in ten normal male subjects who received U-62066E or placebo with low or high dose naloxone in a randomized, double blind study. Blood pressure and heart rate in the supine and standing position, plasm...

journal_title：European journal of clinical pharmacology

authors： Rimoy GH,Wright DM,Bhaskar NK,Rubin PC

更新日期：1994-01-01 00:00:00

abstract：:The purpose of the study was to examine long-term nicotine substitution and its variability during use of a nicotine patch. In two smoking cessation studies a 16-h nicotine patch, releasing 15 mg nicotine, was applied daily for 16 h over 12 weeks, to 167 smokers. Salivary cotinine was highly correlated with plasma cot...

journal_title：European journal of clinical pharmacology

authors： Nørregaard J,Tønnesen P,Simonsen K,Säwe U

更新日期：1992-01-01 00:00:00

abstract：:Twenty-four healthy volunteers participated in a study on the disposition of ergotamine following oral and rectal administration. Plasma samples were collected surrounding each dose of medication and a new mass spectrometry method was used for quantitation of the samples. A mean peak plasma concentration of 454 pg/ml ...

journal_title：European journal of clinical pharmacology

authors： Sanders SW,Haering N,Mosberg H,Jaeger H

更新日期：1986-01-01 00:00:00

abstract：:In healthy normal subjects following the administration of labetalol the pharmacological effects were measured and compared with the plasma concentrations achieved. The inhibition of exercise induced tachycardia and inhibition of exercise induced increases in systolic pressure were significantly related to the adminis...

journal_title：European journal of clinical pharmacology

authors： Richards DA,Maconochie JG,Bland RE,Hopkins R,Woodings EP,Martin LE

更新日期：1977-01-03 00:00:00

abstract：INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) w...

journal_title：European journal of clinical pharmacology

authors： Orme M,Sjöqvist F

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is attributed partially to increased nitric oxide bioavailability. It is possible that functional polymorphisms in endothelial nitric oxide synthase (eNOS) and bradykinin receptor B2 (BDKRB2) genes may affect the antihypertensive res...

journal_title：European journal of clinical pharmacology

authors： Silva PS,Fontana V,Luizon MR,Lacchini R,Silva WA Jr,Biagi C,Tanus-Santos JE

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:This study compares the in vivo relative lung bioavailability of Hydrofluoroalkane (HFA) Seretide delivered via unprimed and unwashed Aerochamber Plus (AP) or Volumatic (VM) spacers, a integrated breath-actuated vortex Synchro-Breathe (SB) device and an Evohaler pMDI (EH) device using adrenal suppression and ea...

journal_title：European journal of clinical pharmacology

authors： Nair A,McKinlay L,Williamson P,Short P,Burns P,Lipworth BJ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:To identify the frequency of CYP2C9*1, *2 and *3 alleles and the genotype of CYP2C9 gene in the Tamilian population. METHODS:The study was conducted on 135 unrelated healthy human volunteers. DNA was extracted from the peripheral leukocytes samples and was analyzed using the polymerase chain reaction (PCR)-...

journal_title：European journal of clinical pharmacology

authors： Adithan C,Gerard N,Vasu S,Balakrishnan R,Shashindran CH,Krishnamoorthy R

更新日期：2003-11-01 00:00:00

abstract：:Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfarin doses were adjusted to maintain the prothrombin time between 25-30% of control and its kinetics were compar...

journal_title：European journal of clinical pharmacology

authors： Almog S,Shafran N,Halkin H,Weiss P,Farfel Z,Martinowitz U,Bank H

更新日期：1985-01-01 00:00:00

abstract：:The effect of cimetidine and ranitidine on doxepin pharmacokinetics was studied in 6 healthy volunteers. Each subject completed 3 study phases: Treatment A, 9 consecutive doses of 50 mg doxepin (once daily); Treatment B, same as Treatment A but co-administration of cimetidine 600 mg b.i.d. starting after the sixth dox...

journal_title：European journal of clinical pharmacology

authors： Sutherland DL,Remillard AJ,Haight KR,Brown MA,Old L

更新日期：1987-01-01 00:00:00

abstract：:A cross-over study of kinetics has been undertaken in 12 healthy adults volunteers using two sustained-release theophylline products that allow once a day dosing (Theo-Dur tablets and Dilatrane A.P. bead filled capsules) to compare the i.v. pharmacokinetic profiles when taken with an hyperlipidic meal and a balanced s...

journal_title：European journal of clinical pharmacology

authors： Brazier JL,Benchekroun Y,Gillet A,Andre C

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:The ABCB1 (MDR1) multidrug transporter plays a key role in determining drug bioavailability. Differences in drug response exist among different ethnic groups. However, until now, no haplotype data are available in a Black African population. METHODS:Exons 2, 7, 10, 11, 12, 14, 17, 21, 26, and the surrounding...

journal_title：European journal of clinical pharmacology

authors： Allabi AC,Horsmans Y,Issaoui B,Gala JL

更新日期：2005-04-01 00:00:00

abstract：:The cellular sources or molecular mechanisms responsible for the derangement of vasoactive prostanoid levels during immunosuppressive cyclosporin (CSA) therapy have not been defined. Using cultured rat glomerular mesangial cells (MC), the cytostatic, cytotoxic and prostanoid synthesis modulating effects of CSA and FK-...

journal_title：European journal of clinical pharmacology

authors： Radeke HH,Kuster S,Kaever V,Resch K

更新日期：1993-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment). The apparent systemic clearance of methotrexate was significantly reduced by all three treatments. Tri...

journal_title：European journal of clinical pharmacology

authors： Tracy TS,Krohn K,Jones DR,Bradley JD,Hall SD,Brater DC

更新日期：1992-01-01 00:00:00

abstract：:Information must be collected, evaluated and utilized to support every qualified activity. Medicine, with a written scientific tradition stretching back more than 2,000 years, is no exception. Here, we discuss a number of important items associated with the establishment of a drug information centre run by clinical ph...

journal_title：European journal of clinical pharmacology

authors： Alván G,Andersson ML,Asplund AB,Böttiger Y,Elwin CE,Gustafsson LL,Öhman B,Törnqvist E

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:In order to document the stereoselective distribution in joints of a chiral nonsteroidal anti-inflammatory drug, the relative affinities of the enantiomers of tiaprofenic acid in synovium and for cartilage were compared. METHODS:The distribution of tiaprofenic acid in synovium and in cartilage was studied 25...

journal_title：European journal of clinical pharmacology

authors： Lapicque F,Mainard D,Gillet P,Payan E,Bannwarth B,Netter P

更新日期：1996-01-01 00:00:00

abstract：:The anti-ischaemic properties of nimodipine 30 mg and 60 mg t.i.d. for 4 days has been tested in a double-blind, placebo-controlled, cross-over study based on the use of hyperventilation to reduce flow velocity in cerebral arteries. Whether the anti-ischaemic properties were due to a vasodilatator action on cerebral b...

journal_title：European journal of clinical pharmacology

authors： Kraaier V,van Huffelen AC,Wieneke GH,Hesselink JM

更新日期：1991-01-01 00:00:00

abstract：:In a model of mental stress the influence of nifedipine and hydrochlorothiazide on stress-induced changes in blood pressure, heart rate, and plasma catecholamines was studied in normal persons. The drugs were used to investigate whether substances with antihypertensive but no particular sympatholytic properties were c...

journal_title：European journal of clinical pharmacology

authors： Heidbreder E,Schafferhans K,Kirsten R,Heidland A

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:People with dementia may have indications for aspirin prescription and clinicians are asked to balance the potential risks against benefits. This review examines the evidence for the risk and benefit of long-term aspirin use in people with dementia aged over 65 years, including randomised controlled trials and ...

journal_title：European journal of clinical pharmacology

authors： Davis KAS,Bishara D,Molokhia M,Mueller C,Perera G,Stewart RJ

更新日期：2021-01-22 00:00:00

abstract：:The pharmacodynamic actions and disposition of diuretic and antihypertensive agents may be significantly modified in subjects with renal disease. Most studies on this question have dealt with alterations in the elimination kinetics of these drugs and, while they generate descriptive data, minimal insight about change...

journal_title：European journal of clinical pharmacology

authors： Mirkin BL,Green TP,O'Dea RF

更新日期：1980-07-01 00:00:00

abstract：:The efficacy and safety of almitrine bismesylate, a new respiratory stimulant, in patients with the hypoxaemic form of chronic respiratory insufficiency caused by chronic bronchitis and emphysema has been assessed. The multicentre trial of 12 weeks duration was double-blind and placebo controlled, with individual and ...

journal_title：European journal of clinical pharmacology

authors： Bakran I,Vrhovac B,Stangl B,Tabori D,Ivicevic A,Todic V,Kandare F

更新日期：1990-01-01 00:00:00

abstract：:Individual variation in the half-life of caffeine in the body was measured by HPLC analysis of saliva samples. The mean for adult males and non-pregnant females was 3.4 h (range 2-5 h, n = 25), and 8.3 h (range 3-16 h, n = 57) for pregnant women. After delivery, in most cases the values returned to normal within one m...

journal_title：European journal of clinical pharmacology

authors： Knutti R,Rothweiler H,Schlatter C

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS:Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-D...

journal_title：European journal of clinical pharmacology

authors： Vanderkam P,Blanchard C,Naudet F,Pouchain D,Vaillant Roussel H,Perault-Pochat MC,Jaafari N,Boussageon R

更新日期：2019-05-01 00:00:00

abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

journal_title：European journal of clinical pharmacology

authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. Howe...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M

更新日期：2016-11-01 00:00:00

abstract：:We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount ext...

journal_title：European journal of clinical pharmacology

authors： Oono S,Tabei K,Tetsuka T,Asano Y

更新日期：1992-01-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：:Effects on psychomotor and cognitive performance of adinazolam (15 or 30 mg), alone and in combination with ethanol (0.8 g/kg), were studied in healthy male volunteers and compared to effects of 10 mg diazepam. Adinazolam 30 mg produced relatively long-lasting impairments on tests of tracking, attention, verbal and no...

journal_title：European journal of clinical pharmacology

authors： Linnoila M,Stapleton JM,Lister R,Moss H,Lane E,Granger A,Greenblatt DJ,Eckardt MJ

更新日期：1990-01-01 00:00:00