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Pharmacokinetics of ergotamine in healthy volunteers following oral and rectal dosing.

Abstract：

:Twenty-four healthy volunteers participated in a study on the disposition of ergotamine following oral and rectal administration. Plasma samples were collected surrounding each dose of medication and a new mass spectrometry method was used for quantitation of the samples. A mean peak plasma concentration of 454 pg/ml was measured an average of 50 min following a 2 mg rectal dose. In contrast, the 2 mg oral dose produced a mean peak plasma concentration of 21 pg/ml an average of 69 min following the dose. Area under the concentration time curve indicated a relative bioavailability of 5% for the oral dosage form. Conflicting data on ergotamine disposition highlight the factors which may be responsible for determining bioavailability and pharmacologic activities of the compound.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Sanders SW,Haering N,Mosberg H,Jaeger H

doi

10.1007/BF00541538

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

331-4

issue

3

eissn

0031-6970

issn

1432-1041

journal_volume

30

pub_type

杂志文章

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