Pharmacokinetics of theophylline and enprofylline in patients requiring a high or low dose of theophylline.

abstract：:Previous studies showed that probucol significantly lowered both LDL cholesterol and HDL cholesterol. In addition, there is evidence that as an essential antioxidant probucol causes variations in cellular interactions and cardiovascular functions in patients. Therefore, 14 hypercholesterolemic men were investigated be...

journal_title：European journal of clinical pharmacology

authors： Berg A,Baumstark MW,Frey I,Halle M,Keul J

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Maintenance of the structural and functional integrity of the skeleton is a critical function of a continuous remodeling driven by highly associated processes of bone resorption and synthetic activities driven by osteoclasts and osteoblasts, respectively. Acceleration of bone turnover, accompanied with a dis...

journal_title：European journal of clinical pharmacology

authors： Leeming DJ,Alexandersen P,Karsdal MA,Qvist P,Schaller S,Tankó LB

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To determine the possible interaction between the antihypertensive agent cicletanine and the hypoglycaemic drug tolbutamide. METHODS:Time-courses of glycaemia and serum immunoreactive insulin (IRI) were followed in 10 healthy subjects after two tolbutamide infusions in each volunteer; initially alone and 9 d...

journal_title：European journal of clinical pharmacology

authors： Bayés MC,Barbanoj MJ,Vallès J,Torrent J,Obach R,Jané F

更新日期：1996-01-01 00:00:00

abstract：:Thirty patients with mild or moderate essential hypertension, and a fixed elevation of diastolic blood pressure, were randomly allocated to three groups and treated with propranolol 40 mg x 4 (Group 1), 80 mg x 4 (group 2) and 160 mg x 4 (Group 3). Blood pressure (BP), pulse rate (PR), plasma renin activity (PRA), pla...

journal_title：European journal of clinical pharmacology

authors： Pedersen EB,Kornerup HJ,Pedersen OL,Andreasen F,Bjerregaard P

更新日期：1981-01-01 00:00:00

abstract：:For model identification and parameter estimation in the framework of linear pharmacokinetics it is most often assumed that the disposition function is a finite sum of exponential functions with time constants lambda i and associated coefficients Ci. Least-square fitting procedures are used to estimate the coefficient...

journal_title：European journal of clinical pharmacology

authors： Schwilden H,Honerkamp J,Elster C

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous...

journal_title：European journal of clinical pharmacology

authors： Schaaf LJ,Campbell SC,Mayersohn MB,Vagedes T,Perrier DG

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the total healthcare costs associated with elderly chronic pain (CP) patients, define cost-related factors in this population, and examine cost evolution over two years. METHOD:This is an ancillary study from the CP S.AGE subcohort, including non-institutionalized patients aged o...

journal_title：European journal of clinical pharmacology

authors： Lazkani A,Delespierre T,Bauduceau B,Pasquier F,Bertin P,Berrut G,Corruble E,Doucet J,Falissard B,Forette F,Hanon O,Benattar-Zibi L,Piedvache C,Becquemont L

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:As an inhibitor of HMG-CoA reductase that catalyses the first step of cholesterol synthesis, pitavastatin undergoes little hepatic metabolism; however, it is a substrate of uptake and efflux transporters. Since pitavastatin is potentially co-administered with agents that affect transporter activities, the pharm...

journal_title：European journal of clinical pharmacology

authors： Chen Y,Zhang W,Huang WH,Tan ZR,Wang YC,Huang X,Zhou HH

更新日期：2013-11-01 00:00:00

abstract：:Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to...

journal_title：European journal of clinical pharmacology

authors： Beglinger C,Born W,Muff R,Drewe J,Dreyfuss JL,Bock A,Mackay M,Fischer JA

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. METHODS:We performed a retrospective analysis of alanine transaminase (ALT) levels in 481 ...

journal_title：European journal of clinical pharmacology

authors： Cai Z,Christianson AM,Ståhle L,Keisu M

更新日期：2009-10-01 00:00:00

abstract：:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the uri...

journal_title：European journal of clinical pharmacology

authors： Olsen H,Bredesen JE,Lunde PK

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk...

journal_title：European journal of clinical pharmacology

authors： Vandraas KF,Spigset O,Mahic M,Slørdal L

更新日期：2010-08-01 00:00:00

abstract：:The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

journal_title：European journal of clinical pharmacology

authors： Coller JK,Christrup LL,Somogyi AA

更新日期：2009-02-01 00:00:00

abstract：:The pharmacokinetics of cefixime following a single oral dose of 200 mg have been investigated in 6 normal subjects and in 22 patients with various degrees of renal insufficiency. Serum and urine samples were collected between 0 and 72 h and were subjected to two methods of analysis: bioassay and HPLC. There was a lin...

journal_title：European journal of clinical pharmacology

authors： Dhib M,Moulin B,Leroy A,Hameau B,Godin M,Johannides R,Fillastre JP

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatmen...

journal_title：European journal of clinical pharmacology

authors： Citarella A,Linder M,Kieler H,Berglind IA,Sundström A,Wettermark B,Andersen M

更新日期：2016-03-01 00:00:00

abstract：:A questionnaire survey was carried out to explore differences in the approach to treatment of patients with Type II diabetes between physicians in Northern Ireland, Norway and Sweden, and to discover to what extent it could account for the three-fold difference in drug use between the countries. A representative sampl...

journal_title：European journal of clinical pharmacology

authors： Griffiths K,McDevitt DG,Andrew M,Baksaas I,Helgeland A,Jervell J,Lunde PK,Oydvin K,Agenäs I,Bergman U

更新日期：1986-01-01 00:00:00

abstract：:Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfarin doses were adjusted to maintain the prothrombin time between 25-30% of control and its kinetics were compar...

journal_title：European journal of clinical pharmacology

authors： Almog S,Shafran N,Halkin H,Weiss P,Farfel Z,Martinowitz U,Bank H

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration (Ctrough) within the target range (50-100 mg/L). METHODS:Ninety-eight childre...

journal_title：European journal of clinical pharmacology

authors： Rodrigues C,Chhun S,Chiron C,Dulac O,Rey E,Pons G,Jullien V

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Zolmitriptan is a 5HT(1B/1D) receptor agonist effective in the acute treatment of migraine. Clinical trials in the USA and Europe have demonstrated the optimal oral therapeutic dose to be 2.5 mg. The 2.5-mg oral tablet has recently been licensed in Japan. OBJECTIVE:To compare the pharmacokinetics of zolmitr...

journal_title：European journal of clinical pharmacology

authors： Yates RA,Tateno M,Nairn K,Ikegami A,Dane A,Kemp J

更新日期：2002-07-01 00:00:00

abstract：:In 8 healthy subjects the absorption of cimetidine was investigated when given alone, together with 60 ml aluminium/magnesium hydroxide containing antacid (neutralising capacity 26 mmol HCl/10 ml), and together with liquid metoclopramide 14 mg. The antacid significantly (P less than 0.01) reduced the bioavailability (...

journal_title：European journal of clinical pharmacology

authors： Gugler R,Brand M,Somogyi A

更新日期：1981-01-01 00:00:00

abstract：:The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty ...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Grennan DM,Siddiqui M

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

journal_title：European journal of clinical pharmacology

authors： Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Studies demonstrating mortality benefit of beta blockers (BB) after myocardial infarction (MI) were conducted before the era of percutaneous intervention and widespread use of statins. Recent retrospective studies show inconsistent results regarding which subgroups of coronary artery disease (CAD) patients' ben...

journal_title：European journal of clinical pharmacology

authors： Verma S,Peterson EL,Liu B,Sabbah HN,Williams LK,Lanfear DE

更新日期：2020-08-01 00:00:00

abstract：:In the 3rd paragraph and 2nd line of the Conclusion section the correct sentence should be: It is now important to encourage policy and decision makers to facilitate and accommodate future linkage of data. ...

journal_title：European journal of clinical pharmacology

authors： Sinnott SJ,Bennett K,Cahir C

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To assess the influence of the P450 oxidoreductase 28 SNP (POR 28) on tacrolimus pharmacokinetics in the Chinese population. METHODS:Seventy-one healthy Chinese volunteers enrolled in the study received an oral dose of 2 mg of tacrolimus after providing written informed consent. CYP3A5 3 was genotyped by polym...

journal_title：European journal of clinical pharmacology

authors： Zhang JJ,Zhang H,Ding XL,Ma S,Miao LY

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The effect of age on the pharmacokinetics and pharmacodynamics of prazosin (alpha 1 adrenoceptor blocker) was studied in 20 healthy volunteers. PATIENTS:Ten elderly (61-81 y) and ten young (23-28 y) subjects were studied. All subjects received 1 mg of prazosin orally in a fasting state. Serial blood samples ...

journal_title：European journal of clinical pharmacology

authors： Andros E,Detmar-Hanna D,Suteparuk S,Gal J,Gerber JG

更新日期：1996-01-01 00:00:00

abstract：:An expert meeting to discuss population pharmacokinetic/pharmacodynamic software was held in Brussels in November 1993 under the auspices of the European Co-operation in Science and Technology (COST), Medicine (B1) programme. Recently developed statistical methods offer the possibility of gaining integrated informatio...

journal_title：European journal of clinical pharmacology

authors： Aarons L,Balant LP,Mentré F,Morselli PL,Rowland M,Steimer JL,Vozeh S

更新日期：1994-01-01 00:00:00

abstract：:The antihypertensive effect of labetalol (L) was compared with that of clonidine (C) in a randomized cross-over study in 17 hypertensive outpatients on bendrofluazide (B). After treatment for two weeks with B(5 mg qd), either L (100 mg tid) or C (0.1 mg tid) was given and their doses were titrated at 2-weekly visits u...

journal_title：European journal of clinical pharmacology

authors： Lilja M,Jounela AJ,Karppanen H

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-ri...

journal_title：European journal of clinical pharmacology

authors： Tsai HH,Lin HW,Chien CR,Li TC

更新日期：2013-03-01 00:00:00

abstract：:An aqueous solution of 35S-ampicillin and polyethylene glycol (PEG 4000, unabsorbable marker) was administered orally to 6 healthy subjects with gastrointestinal tubes. The minimal absorption of radioactive material, as shown by urinary excretion of label, differed markedly between subjects and averaged 44% (25-67). A...

journal_title：European journal of clinical pharmacology

authors： Swahn A

更新日期：1975-12-19 00:00:00