Effect of diuretics and calcium antagonists on circulatory parameters and plasma catecholamines during mental stress.

abstract：:The Danish retail pharmacies' drug subsidy system is completely computerized. The data are person-identifiable, making it possible to chart the population's drug use from the perspective of individual users. We decided to explore the potential of this data source and to analyse heavy drug users specifically. The analy...

journal_title：European journal of clinical pharmacology

authors： Hallas J,Nissen A

更新日期：1994-01-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：:Piretanide 60 mg was administered intravenously over 30 min to 15 men with different degrees of renal failure. The mean piretanide serum concentration at the end of the infusion period was 5.72 +/- 1.51 micrograms/ml. Serum piretanide concentration-time curves declined biexponentially and 24 hours after medication the...

journal_title：European journal of clinical pharmacology

authors： Walter U,Röckel A,Lahn W,Heidland A,Heptner W

更新日期：1985-01-01 00:00:00

abstract：:Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

journal_title：European journal of clinical pharmacology

authors： Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. Howe...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Inconsistent results of lipid-lowering medications (LLMs) on improved cancer survival need more investigations. We tested the hypothesis that adherence to the drug would be associated with a lower cancer-specific mortality in a homogeneous population who has ever used the drug. METHODS:Utilising data from the ...

journal_title：European journal of clinical pharmacology

authors： Feng JL,Qin X

更新日期：2020-10-08 00:00:00

abstract：OBJECTIVE:To determine the patterns of consumption in calcium channel blockers (CCB) groups in the Czech Republic between 1992 and 1999 and make a comparison with selected countries. METHODS:This was part of a drug utilization study using WHO methodology [Anatomical Therapeutic Chemical classification/defined daily do...

journal_title：European journal of clinical pharmacology

authors： Dolezal T,Nemecek K,Krsiak M

更新日期：2002-10-01 00:00:00

abstract：:The function of the hepatic P450 enzyme system was evaluated by measuring the kinetics of antipyrine and serum sex hormone levels were determined in 12 male patients with epilepsy during carbamazepine medication, and two and six months after changing their medication to oxcarbazepine. Antipyrine t1/2 increased and ant...

journal_title：European journal of clinical pharmacology

authors： Isojärvi JI,Pakarinen AJ,Rautio A,Pelkonen O,Myllylä VV

更新日期：1995-01-01 00:00:00

abstract：:The role of mental stress in the development of hypertension and coronary heart disease remains uncertain. Its effects are likely to depend on an interaction of at least three factors: the nature of the stressor, its perception by the individual, and the individual's physiological susceptibility. This type of interact...

journal_title：European journal of clinical pharmacology

authors： Pickering TG

更新日期：1990-01-01 00:00:00

abstract：:Antibiotic cost information was added to the computerized print-out for each patient of microbiology culture results, next to the antibiotic susceptibility list. During the first six months of this addition, the average monthly cost of antibiotics decreased by 16.5% ($7636) compared to the 12 months period preceding t...

journal_title：European journal of clinical pharmacology

authors： Rubinstein E,Barzilai A,Segev S,Samra Y,Modan M,Dickerman O,Haklai C

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Psychosis is a common complication of the drug treatment of Parkinson's disease (PD). Treatment of this complication is difficult as most antipsychotic drugs worsen motor symptoms of PD. Only the atypical antipsychotic clozapine improves psychosis without worsening of parkinsonism. The aim of the present stud...

journal_title：European journal of clinical pharmacology

authors： van de Vijver DA,Roos RA,Jansen PA,Porsius AJ,de Boer A

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the population pharmacokinetics (PK) and exposure-response relationship of edoxaban in patients with non-valvular atrial fibrillation (AF). METHODS:Concentration data from 1,134 subjects in 11 clinical studies (eight phase I, one phase II, and two phase III) were used to p...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Tetsuya K,Miller R

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:To quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database. METHODS:All spontaneous reports of ADRs registered in 2008 by the Midi-Pyrénées PharmacoVigilance Centre that containe...

journal_title：European journal of clinical pharmacology

authors： Montastruc F,Sommet A,Bondon-Guitton E,Durrieu G,Bui E,Bagheri H,Lapeyre-Mestre M,Schmitt L,Montastruc JL

更新日期：2012-05-01 00:00:00

abstract：:The concentration of Torasemide in plasma, dialysate and ultrafiltrate were determined during one haemofiltration and three dialyses. Results show that Torasemide is not significantly eliminated from the blood by these technics. ...

journal_title：European journal of clinical pharmacology

authors： Loute G,Adam A,Ers P,Heremans C,Willems B

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The aim of this meta-analysis was to gather current data and evaluate not only the risk of gastrointestinal (GI) perforation with bevacizumab, but also the potential risk factors for this adverse event. MATERIALS AND METHODS:We carried out a literature search in PubMed for randomized controlled trials (RCTs...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Shen Z,Tang LN,Yao Y

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Valsartan (V), a specific inhibitor of the angiotensin II receptor subtype, AT1, has been developed for treatment of hypertension. Combination therapy with a beta-adrenoceptor blocking agent might be considered in cases with insufficient efficacy of V alone. Therefore, an interaction trial was performed to ev...

journal_title：European journal of clinical pharmacology

authors： Czendlik CH,Sioufi A,Preiswerk G,Howald H

更新日期：1997-01-01 00:00:00

abstract：:The pharmacokinetics of enprofylline, a new potent antiasthmatic, has been studied in 20 healthy, elderly subjects, aged 65 to 81 years, and in 7 young adult controls, aged 23 to 37 years. The dose of 1 mg/kg body weight was given as an i.v. infusion. Plasma levels of enprofylline were followed for about 7 h and urine...

journal_title：European journal of clinical pharmacology

authors： Lunell E,Borgå O

更新日期：1987-01-01 00:00:00

abstract：:Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could ...

journal_title：European journal of clinical pharmacology

authors： Lameijer LD,Voermans LA,Houtzagers JJ,Chadha DR

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

journal_title：European journal of clinical pharmacology

authors： González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

更新日期：2019-06-01 00:00:00

abstract：:The most important cardiovascular interactions between cardioactive drugs and monoamino-oxidase inhibitors or tricyclic antidepressants are reviewed. Post-ganglion blocking agents (e.g., guanethidine), clonidine, reserpine, and alpha-methyl-dopa should not be used in patients needing antide-present therapy. For hypert...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Agué C

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00

abstract：:Arginine vasopressin (AVP) is the major physiological regulator of renal water excretion and blood volume. The AVP pathways of V(1a)R-mediated vasoconstriction and V(2)R-induced water retention represent a potentially attractive target of therapy for edematous diseases. Experimental and clinical evidence suggests bene...

journal_title：European journal of clinical pharmacology

authors： Gassanov N,Semmo N,Semmo M,Nia AM,Fuhr U,Er F

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Gefitinib is one of the standard treatments for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor mutations. It has been reported that acid suppressants (AS) decrease the anti-tumor effect of gefitinib by reducing its solubility. AS is sometimes necessary in cancer patients; however, prev...

journal_title：European journal of clinical pharmacology

authors： Saito Y,Takekuma Y,Kobayashi M,Shinagawa N,Shimizu Y,Kinoshita I,Dosaka-Akita H,Iseki K,Sugawara M

更新日期：2020-10-07 00:00:00

abstract：:Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...

journal_title：European journal of clinical pharmacology

authors： Lameire N,Gordts J

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To evaluate the clinical relevance of the Janus Web Application (JWA) in screening for potential drug-drug interactions (DDIs). METHODS:One hundred and fifty patients taking two drugs or more were studied. Potential DDIs were identified by the JWA. Interviewing the patient and looking into his/her medical reco...

journal_title：European journal of clinical pharmacology

authors： Mannheimer B,Ulfvarson J,Eklöf S,Bergqvist M,von Bahr C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM). METHODS:Two-hour post-dosing concentrations of RMP, INH and PZA were determined in adult TB patients that were studie...

journal_title：European journal of clinical pharmacology

authors： Kumar AK,Chandrasekaran V,Kannan T,Murali AL,Lavanya J,Sudha V,Swaminathan S,Ramachandran G

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:To compare plasma levodopa concentrations after repeated doses of levodopa/carbidopa/entacapone (LCE) and levodopa/carbidopa (LC). METHODS:Open-label, randomized, two-period, active-controlled, cross-over study with four dosing regimens: groups I and II (healthy volunteers and Parkinson's disease patients) ...

journal_title：European journal of clinical pharmacology

authors： Kuoppamäki M,Korpela K,Marttila R,Kaasinen V,Hartikainen P,Lyytinen J,Kaakkola S,Hänninen J,Löyttyniemi E,Kailajärvi M,Ruokoniemi P,Ellmén J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Pharmacovigilance, defined by the World Health Organisation as 'the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem' plays a key role in ensuring that patients receive safe drugs. Our knowledge of a drug's adverse...

journal_title：European journal of clinical pharmacology

authors： Härmark L,van Grootheest AC

更新日期：2008-08-01 00:00:00