Serum sex hormone levels after replacing carbamazepine with oxcarbazepine.

abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

journal_title：European journal of clinical pharmacology

authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. OBJECTIVES:To determine the relative frequencies of different risk factors for OA overdose including di...

journal_title：European journal of clinical pharmacology

authors： Verstuyft C,Robert A,Morin S,Loriot MA,Flahault A,Beaune P,Funck-Brentano C,Jaillon P,Becquemont L

更新日期：2003-03-01 00:00:00

abstract：:A series of elegant experimental studies and careful clinical observation over a decade or more have led to the concept of 'infarct expansion' and 'remodelling' of the heart, culminating in a number of major mortality studies indicating the effectiveness of angiotensin-converting enzyme (ACE) inhibitors in patients af...

journal_title：European journal of clinical pharmacology

authors： Reynolds G,Hall AS,Ball SG

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:This work aimed at building a population pharmacokinetic (PK) model for lamivudine (LMV), stavudine (STV) and zidovudine (ZDV), estimating their inter and intraindividual PK variability and investigating the influence of different covariates. METHODS:Population PK of LMV, STV and ZDV was separately evaluated...

journal_title：European journal of clinical pharmacology

authors： Panhard X,Legrand M,Taburet AM,Diquet B,Goujard C,Mentré F,Cophar 1 - ANRS 102 Study Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To investigate whether the CYP3A4*1G genetic polymorphism contributes to the variability in CYP3A activity and response to fentanyl. METHODS:One hundred and forty-three gynecologic patients who were scheduled to undergo abdominal total hysterectomy or myomectomy with general anesthesia were enrolled in this st...

journal_title：European journal of clinical pharmacology

authors： Zhang W,Chang YZ,Kan QC,Zhang LR,Li ZS,Lu H,Wang ZY,Chu QJ,Zhang J

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The aim of therapeutic regimens using proton pump inhibitors (PPIs) in patients with acid-related diseases is to potently inhibit acid secretion for the full 24 h. However, optimum treatment is still unclear because the pharmacodynamics of PPIs differ among CYP2C19 genotypes and most of the previous studie...

journal_title：European journal of clinical pharmacology

authors： Sugimoto M,Shirai N,Nishino M,Kodaira C,Uotani T,Sahara S,Ichikawa H,Kagami T,Sugimoto K,Furuta T

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:We previously reported that chronic heart failure (CHF) treatments reduce the duration of hospitalisation, even in elderly patients. The present study aimed to determine whether CHF treatment also provides long-term benefits in terms of reduced mortality at 8 years. METHODS:A cohort of 281 patients who were ad...

journal_title：European journal of clinical pharmacology

authors： Maison P,Desamericq G,Hemery F,Elie N,Del'volgo A,Dubois-Randé JL,Hittinger L,Macquin-Mavier I

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:NXY-059 is a nitrone-based, free-radical trapping agent being developed for the treatment of acute ischaemic stroke. Elimination of NXY-059 is primarily renal. The objective of the study was to investigate the pharmacokinetics of NXY-059 in subjects with renal impairment. METHODS:Twenty-four subjects with a ...

journal_title：European journal of clinical pharmacology

authors： Strid S,Borgå O,Edenius C,Jostell KG,Odergren T,Weil A

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

journal_title：European journal of clinical pharmacology

authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:The use of melatonin is increasing among Swedish children and adolescents despite deficient knowledge of usage in these groups. The aim of this study was to investigate the use of melatonin in Swedish children and adolescents according to age, gender, dosage, treatment duration, and use of attention deficit hyp...

journal_title：European journal of clinical pharmacology

authors： Furster C,Hallerbäck MU

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (A...

journal_title：European journal of clinical pharmacology

authors： Levy M,Safadi R,Zylber-Katz E,Granit L,Caraco Y

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:Methantheline is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis. To provide basic information on the pharmacokinetics, magnitude of pharmacodynamic (PD) effects and their correlations with plasma concentrations, we performed ...

journal_title：European journal of clinical pharmacology

authors： Müller C,Lötsch J,Giessmann T,Franke G,Walter R,Zschiesche M,Siegmund W

更新日期：2012-11-01 00:00:00

abstract：:The pharmacokinetics of intravenous enprofylline has been studied in 8 children with asthma. The mean plasma half-life of enprofylline (1.0 h) was considerably shorter than that previously reported in adults. The half-life determined from log urine excretion rate data was identical to the plasma half-life, so urine ex...

journal_title：European journal of clinical pharmacology

authors： Hultqvist C,Borgå O

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg.h-1 for 4 h, starting 1 to 3 h post surgery. Multiple bloo...

journal_title：European journal of clinical pharmacology

authors： Maitre PO,Funk B,Crevoisier C,Ha HR

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Inconsistent results of lipid-lowering medications (LLMs) on improved cancer survival need more investigations. We tested the hypothesis that adherence to the drug would be associated with a lower cancer-specific mortality in a homogeneous population who has ever used the drug. METHODS:Utilising data from the ...

journal_title：European journal of clinical pharmacology

authors： Feng JL,Qin X

更新日期：2020-10-08 00:00:00

abstract：:Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young health volunteers. In order to assessed the inter- and intra-subject variability the following pharmacokinetic parameters were compared: AUC0(24), Cmax, tmax and t 1/2. T...

journal_title：European journal of clinical pharmacology

authors： Jack DB,Quarterman CP,Zaman R,Kendall MJ

更新日期：1982-01-01 00:00:00

abstract：:Individual variation in the half-life of caffeine in the body was measured by HPLC analysis of saliva samples. The mean for adult males and non-pregnant females was 3.4 h (range 2-5 h, n = 25), and 8.3 h (range 3-16 h, n = 57) for pregnant women. After delivery, in most cases the values returned to normal within one m...

journal_title：European journal of clinical pharmacology

authors： Knutti R,Rothweiler H,Schlatter C

更新日期：1981-01-01 00:00:00

abstract：:In seeking the putative mechanism of action of diethyldithiocarbamate (DTC) on the immune status of HIV infected patients, the plasma membrane fluidity of peripheral blood lymphocytes (PBL) from DTC-treated and untreated patients (CDC III-IVc1) was determined. Anisotropy values of the fluorescent probe 6-(9-anthroylox...

journal_title：European journal of clinical pharmacology

authors： Lehr HA,Zimmer JP,Hübner C,Reisinger EC,Kohlschütter A,Claussen M,Schmitz H,Dietrich M

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：:Four subjects received 5 mg 14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg 14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-liv...

journal_title：European journal of clinical pharmacology

authors： Balant L,Fabre J,Zahnd GR

更新日期：1975-01-01 00:00:00

abstract：:The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 m...

journal_title：European journal of clinical pharmacology

authors： Mondorf AW,Breier J,Hendus J,Scherberich JE,Mackenrodt G,Shah PM,Stille W,Schoeppe W

更新日期：1978-05-17 00:00:00

abstract：PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

journal_title：European journal of clinical pharmacology

authors： Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dosing of vancomycin in pediatric patients undergoing continuous venous-venous hemodiafiltration (CVVHDF) is challenging. Characterization of vancomycin pharmacokinetics can assist with dosing and attainment of goal serum concentrations. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS:Patient...

journal_title：European journal of clinical pharmacology

authors： Moffett BS,Morris J,Munoz F,Arikan AA

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to determine the changes in consumption of psychotropic drugs by children aged less than 18 years during the years 1995 to 2001 in the Netherlands. METHODS:The year prevalence of antipsychotics, benzodiazepines, antidepressants and psychostimulants for boys and girls under 18 years w...

journal_title：European journal of clinical pharmacology

authors： Hugtenburg JG,Heerdink ER,Egberts AC

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：:We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

journal_title：European journal of clinical pharmacology

authors： Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study. RESULTS:Both oral and intramuscular artemether were well-tol...

journal_title：European journal of clinical pharmacology

authors： Karbwang J,Na-Bangchang K,Congpuong K,Molunto P,Thanavibul A

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to add to the body of evidence on statin-induced gynecomastia based on data retrieved from the Italian spontaneous adverse drug reaction (ADR) reporting database. METHODS:Spontaneous ADR reports collected in the Italian database up to 31 December 2010 were assessed on a case-by-case b...

journal_title：European journal of clinical pharmacology

authors： Roberto G,Biagi C,Montanaro N,Koci A,Moretti U,Motola D

更新日期：2012-06-01 00:00:00