Decreased plasma membrane fluidity of peripheral blood lymphocytes after diethyldithiocarbamate (DTC) therapy in HIV-infected patients.

abstract：:Protein binding of phenytoin was assesed in one patient with dialysis encephalopathy before and after haemodialysis. Phenytoin concentrations were measured by radioimmunoassay and continuous ultrafiltration was used to assess phenytoin binding. At a serum concentration of 60 micromol.1-1 the percentage of phenytoin bo...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Lawrence JR,Elliott HL,Whiting B

更新日期：1979-02-19 00:00:00

abstract：PURPOSE:Few data on the efficacy and safety of drugs in children are available as in the past, these children were not included in randomized controlled trials (RCTs). Data on the efficacy and safety of drugs in children are extrapolated from adults. The EMA recognizes the need for long-term safety studies on various d...

journal_title：European journal of clinical pharmacology

authors： Verhamme K,Sturkenboom M

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To study the influence of CYP3A4 inhibition by ketoconazole on the disposition of venlafaxine in individuals with different CYP2D6 pheno- and genotypes. METHODS:In an open two-phase study, 21 healthy volunteers with known CYP2D6 pheno- and genotype [14 extensive metabolisers (EMs), 7 poor metabolisers (PMs)]...

journal_title：European journal of clinical pharmacology

authors： Lindh JD,Annas A,Meurling L,Dahl ML,AL-Shurbaji A

更新日期：2003-09-01 00:00:00

abstract：:The consumption of various groups of antihypertensive drugs in Spain during the period 1977-1981 has been measured by the DDD method. The total consumption of the drugs did not change much during this time. Combinations of thiazides with other hypotensives accounted for more than half the total antihypertensive drugs ...

journal_title：European journal of clinical pharmacology

authors： Capellà D,Porta M,Laporte JR

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. METHODS:We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophyllin...

journal_title：European journal of clinical pharmacology

authors： Tsantes AE,Tassiopoulos ST,Papadhimitriou SI,Bonovas S,Poulakis N,Vlachou A,Filioussi K,Loukopoulos D

更新日期：2003-09-01 00:00:00

abstract：:Eight patients were given flunitrazepam 2 mg orally, once daily for 28 consecutive days. The time-course of the plasma concentration of unchanged flunitrazepam and its principal metabolites were studied in detail after the first and last doses. Additional blood samples were collected immediately before administration ...

journal_title：European journal of clinical pharmacology

authors： Wickstrøm E,Amrein R,Haefelfinger P,Hartmann D

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:This study was performed to investigate whether it is possible to use saliva instead of blood usually used for therapeutic drug monitoring (TDM) of disopyramide. METHODS:Six healthy male volunteers ingested 200 mg of disopyramide base, and the disopyramide concentrations in saliva and plasma (total and unbou...

journal_title：European journal of clinical pharmacology

authors： Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...

journal_title：European journal of clinical pharmacology

authors： Newnham DM,Coutie WJ,McFarlane LC,Lipworth BJ

更新日期：1993-01-01 00:00:00

abstract：:Factors which might affect paracetamol disposition have been studied in a heterogenous group of patients in need of mild analgesia in an intensive care unit. Following oral administration of 1 g of paracetamol, plasma and urinary concentrations of the parent compound and metabolites were assessed by HPLC. The renal cl...

journal_title：European journal of clinical pharmacology

authors： Kietzmann D,Bock KW,Krähmer B,Kettler D,Bircher J

更新日期：1990-01-01 00:00:00

abstract：:Previous studies showed that probucol significantly lowered both LDL cholesterol and HDL cholesterol. In addition, there is evidence that as an essential antioxidant probucol causes variations in cellular interactions and cardiovascular functions in patients. Therefore, 14 hypercholesterolemic men were investigated be...

journal_title：European journal of clinical pharmacology

authors： Berg A,Baumstark MW,Frey I,Halle M,Keul J

更新日期：1991-01-01 00:00:00

abstract：AIM:The investigations reported here aimed to evaluate the incremental benefit for dose finding by concentration-response analysis versus dose-response analysis. METHODS:Trials were simulated using an Emax model for a range of scenarios of drug properties, trial design options and target response levels. The simulated...

journal_title：European journal of clinical pharmacology

authors： Berges A,Chen C

更新日期：2013-07-01 00:00:00

abstract：:Deuterated methadone (M-d3) and GCMS were used to study the pharmacokinetics of methadone (M) during the induction stage of methadone maintenance treatment (MMT). A pulse dose of M-d3 was given on Days 1 and 25 of two dosage regimens, one with a continuous 30 mg dose (n = 6), and the other with 30 mg for 10 days, foll...

journal_title：European journal of clinical pharmacology

authors： Nilsson MI,Anggård E,Holmstrand J,Gunne LM

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

journal_title：European journal of clinical pharmacology

authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to appraise the safety profiles of HES preparations and to find out which HES preparation was the most acceptable in cardiovascular surgery through a comparison with control solutions. METHODS:Pertinent randomized controlled trials were selected through a search of Pubmed, Embas...

journal_title：European journal of clinical pharmacology

authors： Shi XY,Zou Z,He XY,Xu HT,Yuan HB,Liu H

更新日期：2011-08-01 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

journal_title：European journal of clinical pharmacology

authors： Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

更新日期：1988-01-01 00:00:00

abstract：:The bioavailability of four preparations containing dihydrotachysterol (DHT2) was tested in two separate trials with administration of single, oral doses of 1 mg per individual. The relative bioavailability of corresponding preparations (capsules vs capsules and oral solution vs oral solution) was tested in a randomis...

journal_title：European journal of clinical pharmacology

authors： Koytchev R,Alken RG,Vagaday M,Kunter U,Kirkov V

更新日期：1994-01-01 00:00:00

abstract：AIMS:The study aimed to identify and describe adverse drug reactions and adherence to clinical guidelines in patients receiving treatment for type 2 diabetes mellitus (T2DM) in Cameroon. METHODS:The method used was a cross-sectional study at a tertiary diabetes care service in Yaoundé, Cameroon. Adult T2DM patients at...

journal_title：European journal of clinical pharmacology

authors： Elangwe A,Katte JC,Tchapmi D,Figueras A,Mbanya JC

更新日期：2020-11-01 00:00:00

abstract：:The cleansing effects on pus and debris of streptokinase-streptodornase and of stabilized crystalline trypsin were compared in 40 patients (12 males, 28 females) with necrotic varicose or arteriosclerotic leg ulcers. Both preparations produced significant partial or total cleansing of the ulcers of necrotic material, ...

journal_title：European journal of clinical pharmacology

authors： Hellgren L

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

journal_title：European journal of clinical pharmacology

authors： van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The use of surgical antibiotic prophylaxis (SAP) in children is poorly characterized. Our aim was to evaluate the effectiveness of a quality improvement (QI) intervention targeting SAP in children, by means of a multicenter prospective intervention study, with a before and after design. METHODS:We prospectivel...

journal_title：European journal of clinical pharmacology

authors： Ciofi Degli Atti M,Alegiani SS,Raschetti R,Arace P,Giusti A,Spiazzi R,Raponi M,APACHE Study Group.

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:A population pharmacokinetic analysis was performed to define domperidone pharmacokinetic parameters in preterm neonates, as no pharmacokinetic data are available in this population. METHODS:An oral domperidone solution was administered (0.75 mg/kg per day) in 32 preterm neonates (64 samples). Domperidone plas...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Drouineau MH,Gournay V,Rozé JC,Jolliet P

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the total healthcare costs associated with elderly chronic pain (CP) patients, define cost-related factors in this population, and examine cost evolution over two years. METHOD:This is an ancillary study from the CP S.AGE subcohort, including non-institutionalized patients aged o...

journal_title：European journal of clinical pharmacology

authors： Lazkani A,Delespierre T,Bauduceau B,Pasquier F,Bertin P,Berrut G,Corruble E,Doucet J,Falissard B,Forette F,Hanon O,Benattar-Zibi L,Piedvache C,Becquemont L

更新日期：2015-08-01 00:00:00

abstract：:Migraine is the most common cause of vascular headache and a highly prevalent illness. In the last 20 years, the discovery of new agents has increased clinical research on migraine. In most of clinical trials that have been conducted, the efficacy was established using a placebo as a control treatment. The objective o...

journal_title：European journal of clinical pharmacology

authors： Macedo A,Farré M,Baños JE

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

journal_title：European journal of clinical pharmacology

authors： Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

更新日期：2020-11-11 00:00:00

abstract：:The pharmacodynamic actions and disposition of diuretic and antihypertensive agents may be significantly modified in subjects with renal disease. Most studies on this question have dealt with alterations in the elimination kinetics of these drugs and, while they generate descriptive data, minimal insight about change...

journal_title：European journal of clinical pharmacology

authors： Mirkin BL,Green TP,O'Dea RF

更新日期：1980-07-01 00:00:00

abstract：:To assess the type and degree of innovation of the cardiovascular drugs centrally approved in the European Union between 1995 and 2002. Sources of information were the European Public Assessment Reports and the Summaries of Product Characteristics published by the European Medicines Evaluation Agency. The Agency appro...

journal_title：European journal of clinical pharmacology

authors： Garattini S,Bertele' V

更新日期：2003-11-01 00:00:00