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Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production.

Abstract：

OBJECTIVE:To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. METHODS:We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophylline (8 mg/kg daily) for at least 1 year, and the other 20 had never received this drug; 38 sex- and age-matched healthy volunteers served as controls. We further studied the development of BFU-E (bursts forming units of erythrocyte precursors) -derived colonies in semisolid methylcellulose cultures in blood samples from 7 patients randomly selected from both groups. In addition, we studied the effects of theophylline on the erythroid cell development by adding this agent to erythroid cell cultures from 6 healthy volunteers at various concentrations. RESULTS:Haemoglobin values were found to be significantly lower in COPD patients treated with theophylline than in those untreated ( P<0.05). Both groups of patients exhibited significantly higher haemoglobin values than normal subjects ( P<0.01 and P<0.001 for treated and untreated patients, respectively). Serum EPO levels did not differ among the three studied groups. Unlike untreated patients and controls, the serum of the theophylline-treated patients produced a significant growth inhibition of erythroid bursts ( P<0.05); the in vitro use of theophylline showed a concentration-dependent inhibition ( P<0.001). CONCLUSION:Our findings confirm the decrease of red cell production, which occurs following administration of theophylline, exclude the possibility of decreased EPO synthesis and suggest a direct inhibitory action of theophylline on erythropoiesis.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Tsantes AE,Tassiopoulos ST,Papadhimitriou SI,Bonovas S,Poulakis N,Vlachou A,Filioussi K,Loukopoulos D

doi

10.1007/s00228-003-0640-0

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

379-83

issue

5-6

eissn

0031-6970

issn

1432-1041

journal_volume

pub_type

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Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production.