当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Population pharmacokinetics of domperidone in preterm neonates.

Population pharmacokinetics of domperidone in preterm neonates.

Abstract：

PURPOSE:A population pharmacokinetic analysis was performed to define domperidone pharmacokinetic parameters in preterm neonates, as no pharmacokinetic data are available in this population. METHODS:An oral domperidone solution was administered (0.75 mg/kg per day) in 32 preterm neonates (64 samples). Domperidone plasma concentration was measured by high-performance liquid chromatography (HPLC) assay, and a one-compartment model with first-order absorption was fitted to the data using NONMEM version V level 1.1. RESULTS:The mean peak and trough plasma concentration values of domperidone were, respectively, 25.3 +/- 20.5 ng/ml and 15.4 +/- 11.4 ng/ml (mean +/- standard deviation). The pharmacokinetic parameters (interindividual variability%) were clearance (Cl/F) = 0.92 L/h (51.6%), volume of distribution (Vd/F) = 0.405 L (68%), and absorption constant rate (Ka) = 0.0843 h(-1) (55.8%). The clearance is not lower than values reported in adults. No influence of covariates (postnatal age, prematurity, weight, gender) on domperidone pharmacokinetic parameters was found. CONCLUSION:This pilot study designed with a limited sampling strategy showed that domperidone plasma concentrations were consistent with those reported in adults, suggesting that domperidone dosage regimen currently used in preterm neonates is suitable.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Dailly E,Drouineau MH,Gournay V,Rozé JC,Jolliet P

doi

10.1007/s00228-008-0535-1

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1197-200

issue

12

eissn

0031-6970

issn

1432-1041

journal_volume

64

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine.

    abstract：:The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thu...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00870989

    authors： Mikus G,Ha HR,Vozeh S,Zekorn C,Follath F,Eichelbaum M

    更新日期：1986-01-01 00:00:00

  • Slower onset of vasodilating action of brain natriuretic peptide (BNP) compared to atrial natriuretic peptide (ANP) in human forearm resistant vessels.

    abstract：PURPOSE:To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans. METHODS:We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-008-0516-4

    authors： Minami H,Yasu T,Tagawa T,Yamakawa K,Ueda S

    更新日期：2008-09-01 00:00:00

  • The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients-a randomized, controlled trial.

    abstract：PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02997-8

    authors： Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

    更新日期：2021-01-01 00:00:00

  • Cytosolic calcium and lymphoproliferative response during calcium antagonism in men.

    abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002280050574

    authors： Lijnen P,Fagard R,Petrov V

    更新日期：1999-02-01 00:00:00

  • Use of fixed doses of beta blocking drugs in the treatment of hypertension. Randomised study of atenolol and penbutolol.

    abstract：:Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00637507

    authors： Lameijer LD,Voermans LA,Houtzagers JJ,Chadha DR

    更新日期：1981-01-01 00:00:00

  • Cardiocirculatory effects of moclobemide (Ro 11-1163), a new reversible, a short-acting MAO-inhibitor with preferential type A inhibition, in healthy volunteers and depressive patients.

    abstract：:The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight h...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00543787

    authors： Gasic S,Korn A,Eichler HG,Oberhummer I,Zapotoczky HG

    更新日期：1983-01-01 00:00:00

  • Antipsychotics and Parkinson's disease: association with disease and drug choice during the first 5 years of antiparkinsonian drug treatment.

    abstract：OBJECTIVE:Psychosis is a common complication of the drug treatment of Parkinson's disease (PD). Treatment of this complication is difficult as most antipsychotic drugs worsen motor symptoms of PD. Only the atypical antipsychotic clozapine improves psychosis without worsening of parkinsonism. The aim of the present stud...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-002-0441-x

    authors： van de Vijver DA,Roos RA,Jansen PA,Porsius AJ,de Boer A

    更新日期：2002-05-01 00:00:00

  • The pharmacokinetics of slow-release procainamide.

    abstract：:Procainamide was given to 20 patients with normal renal function as an i.v. bolus of 500 mg followed by 1.0 or 1.5 g eight-hourly by mouth in the form of a slow release preparation (Durules). 97.6 +/- 27.1 (SD)% of the oral procainamide was absorbed, the absorption half life being 1.54 h. The elimination half life fol...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00560459

    authors： Tilstone WJ,Lawson DH,Campbell W,Hutton I,Lawrie TD

    更新日期：1978-12-01 00:00:00

  • Lack of effect of amoxycillin on the absorption of ofloxacin.

    abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00315484

    authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

    更新日期：1993-01-01 00:00:00

  • Drug therapy management in patients with renal impairment: how to use creatinine-based formulas in clinical practice.

    abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2113-2

    authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

    更新日期：2016-12-01 00:00:00

  • The PRECIS-2 tool seems not to be useful to discriminate the degree of pragmatism of medicine masked trials from that of open-label trials.

    abstract：PURPOSE:To assess, with all available trial information, whether the assessment of the PRECIS-2 nine domains could provide a clear distinction between medicine masked pragmatic randomized controlled trials (pRCTs) and open-label pRCTs. METHODS:A search was conducted of participant-level pRCTs on medicines published on...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-03030-8

    authors： Dal-Ré R

    更新日期：2020-10-26 00:00:00

  • Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.

    abstract：OBJECTIVE:We investigated the effects of treatment with Saint John's wort (hypericum perforatum) extract on the urinary excretion of D-glucaric acid, 6beta-hydroxycortisol, and free cortisol in order to assess the effect of this extract on the activity of hepatic xenobiotic metabolizing enzymes. METHODS:Forty-eight he...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-002-0527-5

    authors： Bauer S,Störmer E,Kerb R,Johne A,Brockmöller J,Roots I

    更新日期：2002-12-01 00:00:00

  • Severe cerebral depression after intoxication with tramadol in a 6-month-old infant.

    abstract：:Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol. ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00543498

    authors： Riedel F,von Stockhausen HB

    更新日期：1984-01-01 00:00:00

  • Pharmacokinetics of clomipramine during pregnancy.

    abstract：PURPOSE:Clomipramine is one of the drugs for depression during pregnancy; however, pharmacokinetic data of clomipramine and its active metabolite desmethylclomipramine in this vulnerable period are lacking. In this study, we describe clomipramine and desmethylclomipramine concentrations including their ratios during pr...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1944-6

    authors： Ter Horst PG,Proost JH,Smit JP,Vries MT,de Jong-van de Berg LT,Wilffert B

    更新日期：2015-12-01 00:00:00

  • The oxidative metabolism of metoprolol in human liver microsomes: inhibition by the selective serotonin reuptake inhibitors.

    abstract：OBJECTIVE:Biotransformation of metoprolol to alpha-hydroxymetoprolol (HM) and O-demethylmetoprolol (ODM) is mediated by CYP2D6. The selective serotonin reuptake inhibitors (SSRIs) are known to inhibit CYP2D6. The aim was to study in vitro the potential inhibitory effect of SSRIs on metoprolol biotransformation. METHOD...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280050456

    authors： Belpaire FM,Wijnant P,Temmerman A,Rasmussen BB,Brøsen K

    更新日期：1998-05-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00610057

    authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期：1983-01-01 00:00:00

  • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers.

    abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00199885

    authors： Merkel U,Sigusch H,Hoffmann A

    更新日期：1994-01-01 00:00:00

  • Drug safety in pregnancy: the German Embryotox institute.

    abstract：:Since 1988, the German Embryotox institute combines individual counselling of pregnant women and their health care providers (HCP) with research on drug safety in pregnancy. In addition, Embryotox offers web-based information which covers the most important and most frequently requested pharmaceutical substances. In c...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-017-2351-y

    authors： Dathe K,Schaefer C

    更新日期：2018-02-01 00:00:00

  • Single- and multiple-dose pharmacokinetics of terodiline in geriatric patients.

    abstract：:As a target group, geriataric patients were selected for pharmacokinetic studies with terodiline (Mictrol), an anticholinergic and calcium antagonist drug effective in the treatment of urinary incontinence. The single-dose kinetics in the geriatric patients (mean age 82 years) differed significantly from that previous...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00540958

    authors： Hallén B,Magnusson A,Bogentoft S,Ekelund P

    更新日期：1988-01-01 00:00:00

  • Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children.

    abstract：PURPOSE:To investigate the impact of valproic acid (VPA) and genetic polymorphism of the major metabolizing enzyme (UGT1A4, UGT2B7) of lamotrigine (LTG) and VPA on LTG concentration in Chinese epileptic children. METHODS:Three single nucleotide polymorphisms (UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2) were analyzed by p...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-015-1925-9

    authors： Liu L,Zhao L,Wang Q,Qiu F,Wu X,Ma Y

    更新日期：2015-11-01 00:00:00

  • The effect of dietary energy and protein deficiency on drug metabolism.

    abstract：:The influence of a diet deficient in energy or protein on hepatic oxidation (Phase I reactions) and glucuronidation (Phase II reactions) in man has been examined. Nine healthy volunteers were fed an energy deficient diet (daily energy intake 4.3 MJ; daily protein intake 0.94 g/kg) and a protein deficient diet (daily e...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00278583

    authors： Hamberg O,Ovesen L,Dorfeldt A,Loft S,Sonne J

    更新日期：1990-01-01 00:00:00

  • Drug interactions between tacrolimus and clotrimazole troche: a data mining approach followed by a pharmacokinetic study.

    abstract：PURPOSE:This study investigated the effects of clotrimazole troche on the risk of transplant rejection and the pharmacokinetics of tacrolimus. METHODS:The data mining approach was used to investigate whether the use of clotrimazole increased the risk of transplant rejection in patients receiving tacrolimus therapy. Pa...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-019-02770-6

    authors： Uno T,Wada K,Hosomi K,Matsuda S,Ikura MM,Takenaka H,Terakawa N,Oita A,Yokoyama S,Kawase A,Takada M

    更新日期：2020-01-01 00:00:00

  • Surveillance of suspected adverse reactions to herbal products used as laxatives.

    abstract：AIM:To describe and evaluate spontaneous reports of suspected adverse reactions (ARs) associated with herbal laxatives received by the Italian Medicines Agency and the Italian National Institute of Health between April 2002 and January 2011. METHODS:Spontaneous reports of suspected ARs were individually analyzed by a ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-011-1128-y

    authors： Vitalone A,Menniti-Ippolito F,Raschetti R,Renda F,Tartaglia L,Mazzanti G

    更新日期：2012-03-01 00:00:00

  • Kinetics of oral and intravenous mexiletine: lack of effect of cimetidine and ranitidine.

    abstract：:The pharmacokinetics of mexiletine, a Class I antiarrhythmic drug, was investigated in 6 healthy volunteers after single oral doses and 15 min intravenous infusions of 3 mg/kg. Cimetidine and ranitidine are commonly used H2-receptor antagonists, which interact adversely with many drugs, e.g. inhibition of the metaboli...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558298

    authors： Brockmeyer NH,Breithaupt H,Ferdinand W,von Hattingberg M,Ohnhaus EE

    更新日期：1989-01-01 00:00:00

  • Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients.

    abstract：PURPOSE:This exploratory study was aimed at elucidating the pharmacogenetics of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) and their implications on docetaxel pharmacokinetics and pharmacodynamics in local Chinese nasopharyngeal cancer patients. METHODS:A total of 59 single nucleotide polymorphisms (SNPs)...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-013-1596-3

    authors： Chew SC,Lim J,Singh O,Chen X,Tan EH,Lee EJ,Chowbay B

    更新日期：2014-02-01 00:00:00

  • (+) and (-) terbutaline are sulphated at a higher rate in human intestine than in liver.

    abstract：:The sulphation of (+) and (-) terbutaline was investigated in specimens of human intestinal mucosa isolated from the duodenum, ileum, ascending colon and sigmoid colon and in specimens of liver and lung. The lung specimens came from 8 current smokers and 11 ex-smokers, the latter having stopped at least 3 months befor...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00315522

    authors： Pacifici GM,Eligi M,Giuliani L

    更新日期：1993-01-01 00:00:00

  • Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study.

    abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-020-02913-0

    authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

    更新日期：2020-09-01 00:00:00

  • A comparison of repaglinide and glibenclamide in the treatment of type 2 diabetic patients previously treated with sulphonylureas.

    abstract：OBJECTIVE:To compare the efficacy and safety of repaglinide, a novel oral prandial glucose regulator, with that of glibenclamide, an oral hypoglycaemic agent, in the treatment of patients with type 2 diabetes. METHODS:This was a 14-week, double-blind, parallel-group trail in which a total of 195 type 2 diabetic patien...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/s002280050613

    authors： Landgraf R,Bilo HJ,Müller PG

    更新日期：1999-05-01 00:00:00

  • Effect of posture and sleep on pharmacokinetics. I. Amoxycillin.

    abstract：:The pharmacokinetics of amoxycillin in normal male volunteers was studied during the states of bedrest, sleep and ambulation. The absorption and disposition of amoxycillin in ambulatory subjects was found to be comparable to that reported previously by other workers. Serum amoxycillin concentrations were found to be s...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00561587

    authors： Roberts MS,Denton MJ

    更新日期：1980-08-01 00:00:00

  • Double-blind plethysmographic study of venous effects of heptaminol adenosine phosphate in patients with primary varicose veins.

    abstract：:Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significant...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00609421

    authors： Schmidt C,Gavoille R,Perez P,Schmitt J

    更新日期：1989-01-01 00:00:00