Kinetics of oral and intravenous mexiletine: lack of effect of cimetidine and ranitidine.

abstract：OBJECTIVE:Carvedilol, a beta-adrenoceptor blocking agent with additional alpha(1)-adrenoceptor blocking properties, has been shown to improve left ventricular function in chronic heart failure (CHF). However, its effect on mortality has recently been the subject of controversial discussion. The aim of this meta-analysi...

journal_title：European journal of clinical pharmacology

authors： Schmidt BM,Janson CP,Wehling M

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate and characterise adverse drug reactions (ADRs) to drugs used in France for orthostatic hypotension (OH). METHODS:In this prospective and systematic study, 121 consecutive out-patients suffering from primary (Parkinson's disease, pure autonomic failure, multiple...

journal_title：European journal of clinical pharmacology

authors： Pathak A,Raoul V,Montastruc JL,Senard JM

更新日期：2005-07-01 00:00:00

abstract：:To assess the partial agonist activity of cicloprolol in man, four studies were carried out in normal male volunteers. I and II. Open dose escalating studies of the effects of oral doses of the drug on exercise tachycardia and sleeping heart rate. III and IV. Double-blind randomized studies of the effects of placebo, ...

journal_title：European journal of clinical pharmacology

authors： McCaffrey PM,Burke M,Riddell JG,Shanks RG

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetics and organ distribution of i.v. and oral methylene blue, which is used to prevent ifosfamide-induced encephalopathy in oncology. METHODS:The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after i.v....

journal_title：European journal of clinical pharmacology

authors： Peter C,Hongwan D,Küpfer A,Lauterburg BH

更新日期：2000-06-01 00:00:00

abstract：:The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under ...

journal_title：European journal of clinical pharmacology

authors： Narang AP,Datta DV,Nath N,Mathur VS

更新日期：1981-01-01 00:00:00

abstract：:The mode and site of action of the new diuretic agent piretanide were investigated in man. The effect of a single oral dose of 12 mg was compared with that of furosemide 80 mg p.o. iin 6 patients with the nephrotic syndrome. Piretanide showed a greater diuretic and natriuretic response than furosemide during maximal w...

journal_title：European journal of clinical pharmacology

authors： Marone C,Reubi FC

更新日期：1980-01-01 00:00:00

abstract：:We have studied 16 healthy men to evaluate preliminary pharmacodynamics and kinetics of BW443C given by i.v. infusions. Four volunteers received escalating doses at weekly intervals, starting at 0.1 microgram.kg-1 for 60 min and increasing to a maximum of 2.0 micrograms.kg-1.min-1 for 180 min. Subsequently 12 differen...

journal_title：European journal of clinical pharmacology

authors： Posner J,Dean K,Jeal S,Moody SG,Peck AW,Rutter G,Telekes A

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I). The pharmacokinetic parameters of the act...

journal_title：European journal of clinical pharmacology

authors： Nakashima M,Yamamoto J,Shibata M,Uematsu T,Shinjo H,Akahori T,Shioya H,Sugiyama K,Kawahara Y

更新日期：1992-01-01 00:00:00

abstract：:Levosimendan is a new calcium-sensitiser intended for the treatment of congestive heart failure. The results of preclinical studies indicate it has positive inotropic and vasodilator effects. In the open study reported here up to 5 mg levosimendan and vehicle were administered to 8 healthy male volunteers at one- to 2...

journal_title：European journal of clinical pharmacology

authors： Lilleberg J,Sundberg S,Häyhä M,Akkila J,Nieminen MS

更新日期：1994-01-01 00:00:00

abstract：:In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Follo...

journal_title：European journal of clinical pharmacology

authors： Seymour RA,Williams FM,Oxley A,Ward A,Fearns M,Brighan K,Rawlins MD,Jones PM

更新日期：1984-01-01 00:00:00

abstract：:The effects of an oral dose of atropine (0.03 mg/kg body weight) and an IM (0.02 mg/kg) dose on the heart rate and salivary flow in seven healthy adult volunteers were compared to see whether the oral dose was sufficient to inhibit vagal reflexes of the heart. Atropine concentrations in plasma were determined by an M2...

journal_title：European journal of clinical pharmacology

authors： Volz-Zang C,Waldhäuser T,Schulte B,Palm D

更新日期：1995-01-01 00:00:00

abstract：:The pharmacokinetics, hypotensive effect and tolerability of a new vasodilator, tolmesoxide (T), have been studied in 6 uncontrolled hypertensive patients receiving atenolol and diuretic. After a 50 mg oral dose mean (+/- SD) peak plasma concentration of T was 1.13 +/- 0.29 micrograms/ml-1 and occurred 0.79 +/- 0.40 h...

journal_title：European journal of clinical pharmacology

authors： Silas JH,Phillips FC,Freestone S,Tucker GT,Ramsay LE

更新日期：1981-01-01 00:00:00

abstract：:The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males. Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, ...

journal_title：European journal of clinical pharmacology

authors： Krämer BK,Häussler M,Ress KM,Müller GA,Burger KJ,Risler T

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Administration of fluvoxamine (FLV) with concomitant benzodiazepines is common in clinical situations. We studied the effects of the coadministration of FLV on plasma concentrations of alprazolam (ALP). We also studied the effects of CYP2C19(*)2 or CYP2C19(*)3 on these drug interactions. METHODS:The subject...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Shioiri T,Muratake T,Kawashima Y,Sato S,Hagiwara M,Inoue Y,Shimoda K,Someya T

更新日期：2003-04-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：:Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol. ...

journal_title：European journal of clinical pharmacology

authors： Riedel F,von Stockhausen HB

更新日期：1984-01-01 00:00:00

abstract：:Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after intravenous or oral administration, which indicate...

journal_title：European journal of clinical pharmacology

authors： Hengstmann JH,Weyand U,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:Intensive monitoring of adverse drug reactions (ADR) in infants and preschool children in the paediatric outpatient unit covering the town of Karlovac (150,000 inhabitants) was performed over a period of three months. Data were obtained by physical examination of children and the history given by their parents. In all...

journal_title：European journal of clinical pharmacology

authors： Cirko-Begović A,Vrhovac B,Bakran I

更新日期：1989-01-01 00:00:00

abstract：:Naftopidil exerts its antihypertensive action via alpha 1-adrenoceptor blockage and Ca2+ antagonism in vascular smooth muscle. Since the chemically similar 1-(1-naphthyl) piperazine is known to be a 5-hydroxytryptamine2 receptor antagonist, the 5-hydroxytryptamine (5-HT) antagonistic properties of naftopidil were test...

journal_title：European journal of clinical pharmacology

authors： Kirsten R,Breidert M,Nelson K,Heine A,Rosenkranz S,Erdeg B,Niebch G,Borbe HO,Siebert-Weigel M,Respondek J

更新日期：1994-01-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:Exposure to reserpine was compared in 181 women interviewed prior to biopsy and found to have breast cancer and 307 women found to have a benign disorder of the breast. The age-adjusted relative risk of breast cancer in those who had taken reserpine was 0.6 (95% confidence limits: 0.4 and 1.1). When the 181 breast can...

journal_title：European journal of clinical pharmacology

authors： Kewitz H,Jesdinsky HJ,Schröter PM,Lindtner E

更新日期：1977-01-03 00:00:00

abstract：PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from indivi...

journal_title：European journal of clinical pharmacology

authors： Plet HT,Hallas J,Kjeldsen LJ

更新日期：2013-10-01 00:00:00

abstract：:A new data analysis approach, NON-MEM, proposed by Sheiner and Beal, has been employed to estimate the population pharmacokinetic parameters of oral mexiletine in patients treated for arrhythmias. 452 serum concentration measurements in 58 patients were available for analysis. 27 patients had congestive heart failure ...

journal_title：European journal of clinical pharmacology

authors： Vozeh S,Katz G,Steiner V,Follath F

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Pharmacovigilance, defined by the World Health Organisation as 'the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem' plays a key role in ensuring that patients receive safe drugs. Our knowledge of a drug's adverse...

journal_title：European journal of clinical pharmacology

authors： Härmark L,van Grootheest AC

更新日期：2008-08-01 00:00:00

abstract：:The relationship between the pharmacokinetics and pharmacodynamics of enoximone, a new positive inotropic agent, was investigated in 6 healthy men. The volunteers received single oral and i.v. doses of 3 and 1 mg/kg, respectively, and placebo in a double-blind cross-over trial. Plasma concentrations of enoximone and i...

journal_title：European journal of clinical pharmacology

authors： Belz GG,Meinicke T,Schäfer-Korting M

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:This study was performed to investigate whether it is possible to use saliva instead of blood usually used for therapeutic drug monitoring (TDM) of disopyramide. METHODS:Six healthy male volunteers ingested 200 mg of disopyramide base, and the disopyramide concentrations in saliva and plasma (total and unbou...

journal_title：European journal of clinical pharmacology

authors： Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

更新日期：1997-01-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The analgesic efficacy of intravenous doses of acetaminophen (paracetamol) 0.5 g, 1 g and 2 g (administered as propacetamol) was assessed in 11 healthy subjects in a randomised, double-blind, placebo-controlled crossover study. The antinociceptive effect was assessed over 8 h by measurement of the nociceptive...

journal_title：European journal of clinical pharmacology

authors： Piguet V,Desmeules J,Dayer P

更新日期：1998-01-01 00:00:00

abstract：:The effects of the beta-blocker atenolol on vigilance, concentration, and psychophysiological condition were determined by measuring visual reaction time and choice reaction time in volunteers subjected to combined physical and mental stress. Atenolol 50 mg or placebo were administered for three days in a double-blind...

journal_title：European journal of clinical pharmacology

authors： Harms D

更新日期：1985-01-01 00:00:00