Effects of a new diuretic (piretanide) compared with furosemide on renal diluting and concentrating mechanisms in patients with the nephrotic syndrome.

abstract：:The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial. Enprofylline 4 mg/kg and theophylline 8 mg/kg produced mean maximum plasma levels of 4...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Søndergaard I,Weeke B

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:In-hospital statin dosage-related effect remains unknown for patients with arteriosclerotic cardiovascular disease (ASCVD). This study aimed to determine the associations of different in-hospital intensive statins dosages with the prognosis for patients in the era of percutaneous coronary intervention (PCI). M...

journal_title：European journal of clinical pharmacology

authors： Chen PY,Liu YH,Duan CY,Fan HL,Zeng LH,Guo W,Jiang L,Wei XB,He WF,Tao S,Guo ZQ,Chen JY,Tan N,He PC

更新日期：2020-12-01 00:00:00

abstract：:Atenolol 100 mg and penbutolol 40 mg given once a day were both effective in controlling moderate hypertension, as judged by a randomised controlled, double-blind trial in 45 patients treated for six weeks. Both drugs significantly reduced the resting supine and erect blood pressures. No serious adverse effects could ...

journal_title：European journal of clinical pharmacology

authors： Lameijer LD,Voermans LA,Houtzagers JJ,Chadha DR

更新日期：1981-01-01 00:00:00

abstract：:Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was decreased. The ch...

journal_title：European journal of clinical pharmacology

authors： Elmgreen J,Tougaard L,Leth A,Christensen MS

更新日期：1980-10-01 00:00:00

abstract：PURPOSE:Anaphylaxis is a potentially fatal systemic adverse drug reaction (ADR). It is an unpredictable and mostly dose-independent event that occurs suddenly following exposure to the causative drug. Our objective was to characterize a case series of anaphylactic reactions reported to the Portuguese Pharmacovigilance ...

journal_title：European journal of clinical pharmacology

authors： Ribeiro-Vaz I,Marques J,Demoly P,Polónia J,Gomes ER

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to determine the frequencies of important allelic variants of two drug targets, dipeptidyl carboxypeptidase ( DCP1) and cholesteryl ester transfer protein ( CETP), and two other drug receptors, beta-2 adrenergic receptor ( ADRB2) and 5-hydroxy tryptamine 2A receptor ( HTR2A), in the...

journal_title：European journal of clinical pharmacology

authors： Hamdy SI,Hiratsuka M,Narahara K,El-Enany M,Moursi N,Ahmed MS,Mizugaki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：:The comparative enzyme inducing effects of rifabutin and the chemically related drug rifampicin have been investigated in 8 normal subjects. Rifampicin 600 mg daily for 7 days caused considerable shortening of the antipyrine half-life and a marked increase in antipyrine clearance, associated with an increased rate of ...

journal_title：European journal of clinical pharmacology

authors： Perucca E,Grimaldi R,Frigo GM,Sardi A,Mönig H,Ohnhaus EE

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Spontaneous reporting is the most common method used in pharmacovigilance and the best one to generate signals on new or rare adverse drug reactions (ADRs). Under-reporting is a major drawback of this system. The objective of this study was to quantify the extent of under-reporting in general practice and to ...

journal_title：European journal of clinical pharmacology

authors： Alvarez-Requejo A,Carvajal A,Bégaud B,Moride Y,Vega T,Arias LH

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety profiles after coadministration of clarithromycin, amoxicillin, and il...

journal_title：European journal of clinical pharmacology

authors： Jin BH,Yoo BW,Park J,Kim JH,Lee JY,Shin JS,Park MS

更新日期：2018-09-01 00:00:00

abstract：:The influence of time of drug administration on pharmacokinetics of theophylline was studied both after ingestion of a sustained-release tablet, containing choline theophyllinate ( Zy 15061-S. R.; Teovent ; Sabidal ; ZYMA S.A.) and after intravenous infusion of aminophylline to eight healthy volunteers. Both drugs wer...

journal_title：European journal of clinical pharmacology

authors： Jonkman JH,van der Boon WJ,Balant LP,Schoenmaker R,Holtkamp A

更新日期：1984-01-01 00:00:00

abstract：:Ten normal adult tobacco smokers and 10 nonsmoking volunteers 20-31 years of age were the subjects of this study. The tobacco smokers all had a history of daily tobacco smoking. They were asked to stop smoking for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured on different days...

journal_title：European journal of clinical pharmacology

authors： Domino EF,Kadoya C,Matsuoka S

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:A population pharmacokinetic analysis was performed to define domperidone pharmacokinetic parameters in preterm neonates, as no pharmacokinetic data are available in this population. METHODS:An oral domperidone solution was administered (0.75 mg/kg per day) in 32 preterm neonates (64 samples). Domperidone plas...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Drouineau MH,Gournay V,Rozé JC,Jolliet P

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：:The concentrations of lormetazepam and its glucuronide in plasma and milk were determined during administration of 10 daily doses of lormetazepam 2 mg (2 tablets of Noctamid-1) to five mothers delivered by Caesarian section. Their babies were breast-fed throughout the study, and the plasma levels of lormetazepam and i...

journal_title：European journal of clinical pharmacology

authors： Hümpel M,Stoppelli I,Milia S,Rainer E

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Inconsistent results of lipid-lowering medications (LLMs) on improved cancer survival need more investigations. We tested the hypothesis that adherence to the drug would be associated with a lower cancer-specific mortality in a homogeneous population who has ever used the drug. METHODS:Utilising data from the ...

journal_title：European journal of clinical pharmacology

authors： Feng JL,Qin X

更新日期：2020-10-08 00:00:00

abstract：:The effects of sodium nitroprusside (SNP) and 3-morpholino sydnonimine (SIN-1), isosorbide dinitrate (ISDN) and glyceryl trinitrate (GTN), and molsidomine (the inactive precursur of SIN-1) on monocyte chemotaxis and cyclic GMP (cGMP) concentration were studied. SNP and SIN-1 inhibited monocyte N-formyl-methionyl-leucy...

journal_title：European journal of clinical pharmacology

authors： Bath PM

更新日期：1993-01-01 00:00:00

abstract：:The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 ...

journal_title：European journal of clinical pharmacology

authors： Libert JP,Weber LD,Amoros C,Muzet A,Ehrhart J,Follenius M

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:Network meta-analysis (NMA) is a new technique that allows multiple treatment comparisons and provides estimates of effect sizes for all possible pair-wise comparisons. Several NMAs of antiepileptic drug (AED) efficacy and tolerability in individuals with refractory focal epilepsy, however, came to non-specific...

journal_title：European journal of clinical pharmacology

authors： Zaccara G,Giovannelli F,Bell GS,Sander JW

更新日期：2014-06-01 00:00:00

abstract：:Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during...

journal_title：European journal of clinical pharmacology

authors： Zilly W,Breimer DD,Richter E

更新日期：1977-04-20 00:00:00

abstract：PURPOSE:The use of melatonin is increasing among Swedish children and adolescents despite deficient knowledge of usage in these groups. The aim of this study was to investigate the use of melatonin in Swedish children and adolescents according to age, gender, dosage, treatment duration, and use of attention deficit hyp...

journal_title：European journal of clinical pharmacology

authors： Furster C,Hallerbäck MU

更新日期：2015-07-01 00:00:00

abstract：:Jejunal perfusion was performed in 12 healthy volunteers to evaluate the dose dependent effects of loperamide on intestinal absorption, stimulated secretion and transit. In 6 volunteers intestinal perfusion of the jejunal segment with isotonic NaCl solution was followed by addition of loperamide in increasing doses (2...

journal_title：European journal of clinical pharmacology

authors： Press AG,Ewe K,Schmidt J,Junge H

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially life-threatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this...

journal_title：European journal of clinical pharmacology

authors： Sharifzadeh S,Mohammadpour AH,Tavanaee A,Elyasi S

更新日期：2020-10-06 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor receptor 4 (FGFR4) expression has association with tumor malignancy. In thyroid cancers, FGFR4 has been reported to be characteristically expressed in aggressive thyroid tumors, such as anaplastic thyroid carcinoma (ATC). METHODS:We investigated FGFR4 expression in patients with ATC an...

journal_title：European journal of clinical pharmacology

authors： Yamazaki H,Yokose T,Hayashi H,Iwasaki H,Osanai S,Suganuma N,Nakayama H,Masudo K,Rino Y,Masuda M

更新日期：2020-05-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:In animal studies, it has been shown that verapamil reduces strength and endurance of the diaphragm and inhibits the beneficial effects of theophylline. We examined whether the use of verapamil in patients with severe chronic obstructive pulmonary disease (COPD) who use theophylline leads to a deterioration o...

journal_title：European journal of clinical pharmacology

authors： Broeders ME,Heijdra YF,Smits P,Folgering HT,Kramers C

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:To gain insight into the experiences and handling of adverse drug reactions (ADRs) by the staffs of public primary healthcare (PHC) clinics in Eastern Cape Province, South Africa, as well as their perceptions of related adherence challenges in the treatment and follow-up of human immunodeficiency virus (HIV)-po...

journal_title：European journal of clinical pharmacology

authors： Ruud KW,Srinivas SC,Toverud EL

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:We assessed possible drug interactions of tramadol given concomitantly with the potent CYP2B6 inhibitor ticlopidine, alone or together with the potent CYP3A4 and P-glycoprotein inhibitor itraconazole. METHODS:In a randomized, placebo-controlled cross-over study, 12 healthy subjects ingested 50 mg of tramadol a...

journal_title：European journal of clinical pharmacology

authors： Hagelberg NM,Saarikoski T,Saari TI,Neuvonen M,Neuvonen PJ,Turpeinen M,Scheinin M,Laine K,Olkkola KT

更新日期：2013-04-01 00:00:00